Search results

1

Artificial skin composites

100%

Ładniak A.

Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia

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2018

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vol. 73

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issue 1

EN

Skin injuries are a health problem and can lead to serious, significant deterioration in the quality of life and, consequently, even illness and disability. Therefore, after wounding, immediate regeneration of the tissue is necessary to avoid further complications and pathogenesis. Consequently, many wound healing strategies have been developed, leading to the progress in constructing of multifunctional tissue substitutes for the skin, biomembranes, scaffolds and intelligent dressings. The field of science focusing on the creation of the above-mentioned products is tissue engineering (TE). Its main goal is to find a system that is able to replace or be a model that perfectly mimics the form and function of the skin. Research carried out on such constructs is mainly based on the analysis of mechanical properties (porosity, elasticity), as well as the assessment of the impact of individual components on processes related to the formation of new tissue as cell proliferation and differentiation, proliferation, angiogenesis - through in vivo studies (using animal models: mice, New Zealand rabbits) and in vitro (most often using mouse fibroblasts - L929). Skin constructions may have potential applications as wound dressings or skin substitutes in cases of severe skin damage.

2

CHARACTERISATION OF CHITOSAN/HYALURONIC ACID BLEND FILMS MODIFIED BY COLLAGEN

88%

Lewandowska K., Alina S., Grabska S., Michalska M.

Progress on Chemistry and Application of Chitin and its Derivatives

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2017

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vol. 22

125-134

EN

In the present study, thin films based on the blends of chitosan (Ch) and hyaluronic acid (HA) with and without collagen (Coll) were characterised using tensile tests, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and thermogravimetric analysis (TGA). Ch/HA and Ch/HA/Coll polymer blends were prepared using the solvent evaporation technique. The interactions between polymer components in the binary and ternary blends were studied by FTIR analysis. Mechanical properties were studied and compared with those of simple polymer films. These results show that the addition of collagen into Ch/HA blends led to the increase of tensile strength and Young modulus. Moreover, it was found that the thermal stability of the Ch/HA binary blend significantly increased upon the addition of collagen.

3

INFLUENCE OF THE INTERMOLECULAR INTERACTION ON PHYSICO-CHEMICAL PROPERTIES OF CHITOSAN/HYALURONIC ACID BLENDS

88%

Lewandowska K., Alina S., Grabska S.

Progress on Chemistry and Application of Chitin and its Derivatives

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2015

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vol. 20

170-176

EN

In the present study, the results of viscosity measurements in dilute solutions of chitosan (Ch) with hyaluronic acid (HA) are presented. Chitosan is blended with hyaluronic acid in aqueous 0.1M CH3COOH/0.2M NaCl and 0.3M NaCl respectively, or with the addition of HEPES. Viscosity measurements of dilute polymer solution were carried out in an Ubbelohde capillary viscometer. The intrinsic viscosity, [], and the viscosity interaction parameters, bm, have been determined for the binary (solvent/polymer) and ternary (solvent/polymer A/polymer B) systems. The homogeneity and morphology of chitosan blends were ascertained from the tapping-mode atomic force microscopy. The surface roughness of chitosan, hyaluronic acid and Ch/HA blended films was altered by mixing. The obtained results suggested that there was existence of the strong interactions between chitosan and hyaluronic acid.

4

Elevated level of ambient glucose stimulates the synthesis of high-molecular-weight hyaluronic acid by human mesangial cells. The involvement of transforming growth factor β1 and its activation by thrombospondin-1

88%

Yevdokimova N. Y.

Acta Biochimica Polonica

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2006

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vol. 53

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issue 2

383-393

EN

The dysregulation of the metabolism of glycosaminoglycan and protein components of extracellular matrix (ECM) is a typical feature of diabetic complications. High glucose-induced enrichment of ECM with hyaluronan (HA) not only affects tissue structural integrity, but influences cell metabolic response due to the variety of effects depending on the HA polymer molecular weight. TSP-1-dependent activation of TGFβ1 axis is known to mediate numerous matrix disorders in diabetes, but its role concerning HA has not been studied so far. In this work we demonstrated that 30 mM D-glucose increased the incorporation of [3H]glucosamine in high-molecular-weight (> 2000 kDa) HA of medium and matrix compartments of human mesangial cultures. Simultaneously, the synthesis of HA with lower molecular weight and HA degradation were not altered. The cause of the increased high-molecular-weight HA synthesis consisted in the up-regulation of hyaluronan synthase (HAS) 2 mRNA without alterations of the expression of HAS3, which generates HA of lower molecular weight. D-Glucose at 30 mM also stimulated the production of transforming growth factor β1 (TGFβ1), the excessive activation of which was determined by the up-regulation of thrombospondin-1 (TSP-1). The blockage of TGFβ1 action either by neutralizing anti-TGFβ1 antibodies or by quenching the TGFβ1 activation (with TSP-1-derived synthetic GGWSHW peptide) abolished the effect of high glucose on HAS2 mRNA expression and normalized the synthesis of HA. Exogenous human TGFβ1 had the same effect on HAS2 expression and HA synthesis as high glucose treatment. Therefore, we supposed that TSP-1-dependent TGFβ1 activation is involved in the observed high glucose effect on HA metabolism. Since high-molecular-weight HA polymers, unlike middle- and low-molecular weight HA oligosaccharides, are known to possess anti-inflammatory and anti-fibrotic functions, we suppose that the enrichment of mesangial matrix with high-molecular-weight HA may represent an endogenous mechanism to limit renal injury in diabetes.

5

THE INFLUENCE OF THE TYPE SOLVENT ON THE STRUCTURE OF CHITOSAN BLENDS WITH HYALURONIC ACID

88%

Lewandowska K., Sionkowska A., Grabska S.

Progress on Chemistry and Application of Chitin and its Derivatives

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2016

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vol. 21

147-153

EN

The influence of the type solvent on the structure of chitosan, hyaluronic acid and their blend films was investigated. Aqueous acetic acid, hydrochloric acid, sodium chloride and aqueous acetic acid/NaCl were used as solvents for chitosan, hyaluronic acid and Ch/HA solution blends. Ch, HA and their blend films were prepared by casting technique. The homogeneity and morphology of chitosan blends were ascertained from the tapping-mode atomic force microscopy (AFM) and scanning electron microscopy (SEM). The changes of topography images are considered by determining the root mean square (RMS, Rq) deviation in the image data. The surface roughness of chitosan, hyaluronic acid and Ch/HA blended films was altered by mixing. The structure of chitosan blends with hyaluronic acid depends on the blend composition and on the solvent used for preparing the blend.

6

Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in children with non-alcoholic fatty liver disease

75%

Lebensztejn D. M., Wierzbicka A., Socha P., Pronicki M., Skiba E., Werpachowska I., Kaczmarski M.

Acta Biochimica Polonica

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2011

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vol. 58

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issue 4

563-566

EN

Objectives: There is a need to replace liver biopsy with non-invasive markers that predict the degree of liver fibrosis in fatty liver disease related to obesity. Therefore, we studied four potential serum markers of liver fibrosis and compared them with histopathological findings in liver biopsy in children with non-alcoholic fatty liver disease (NAFLD). Methods: We determined fasting serum level of hyaluronic acid (HA), laminin, YKL-40 and cytokeratin-18 M30 in 52 children (age range 4-19, mean 12 years, 80 % of them were overweight or obese) with biopsy-verified NAFLD. Viral hepatitis, autoimmune and metabolic liver diseases (Wilson's disease, alpha-1-antitrypsin deficiency, cystic fibrosis) were excluded. Fibrosis stage was assessed in a blinded fashion by one pathologist according to Kleiner. Receiver operating characteristics (ROC) analysis was used to calculate the power of the assays to detect liver fibrosis (AccuROC, Canada). Results: Liver fibrosis was diagnosed in 19 children (37 %). The levels of HA and CK18M30 were significantly higher in children with fibrosis compared to children without fibrosis (p=0.04 and 0.05 respectively). The ability of serum HA (cut-off 19.1 ng/ml, Se=84 %, Sp=55 %, PPV=52 %, NPV=86 %) and CK18M30 (cut-off 210 u/l, Se=79 %, Sp=60 %, PPV=56 %, NPV=82 %) to differentiate children with fibrosis from those without fibrosis was significant (AUC=0.672 and 0.666, respectively). The combination of both markers was superior (AUC=0.73, p=0.002). Laminin and YKL-40 levels did not allow a useful prediction. Conclusions: Cytokeratin-18 and hyaluronic acid are suitable serum markers predicting liver fibrosis in children with NAFLD. Studying these markers may identify patients at risk of disease progression.

7

The role of serum hyaluronic acid determination in the diagnosis of liver fibrosis

75%

Gudowska M., Cylwik B., Chrostek L.

Acta Biochimica Polonica

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2017

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vol. 64

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issue 3

451-457

EN

The common pathway leading to liver fibrosis and cirrhosis is growing deposition of extracellular matrix (ECM). It results from molecular and histological rearrangement of collagens, glycoproteins and hyaluronans. Hyaluronic acid is a chief component of the extracellular matrix of connective tissues and plays the main structural role in the formation of ECM. The most important organ involved in the synthesis of hyaluronic acid is the liver. In this paper the meaning of hyaluronic acid in the diagnostics of liver diseases is discussed. Here, we focus on the described changes of hyaluronic acid concentration in the pathological processes of the liver, including alcoholic and non-alcoholic liver diseases. The results of published clinical studies have shown its high diagnostic sensitivity, which probably enables its application in laboratory diagnosis.

8

The role of an oral formulation of hyaluonic acid and chondroitin sulphate in the treatment of patients with laryngopharyngeal reflux

75%

Chmielecka-Rutkowska J., Tomasik B., Pietruszewska W.

Polish Journal of Otolaryngology

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2019

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vol. 73

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issue 6

38-49

EN

Introduction: Proton pump inhibitors (PPIs) have become an important breakthrough in the treatment of gastroesophageal reflux disease (GERD). However, in patients with laryngopharyngeal reflux (LPR) – one of the extraesophageal variants of the disease – the efficacy of PPI is incomplete or limited and alleviation of symptoms requires additional medications. As of today, the importance of hyaluronic acid (HA) and chondroitin sulphate (CS) and their role in mucosal damage healing, most particularly within the larynx, is being highlighted. Objective: The objective of the study was to assess the outcomes of treatment in LPR patients receiving a combination of hyaluronic acid and chondroitin sulfate (HA + CS) on a bioadhesive carrier. Material and methods: A total of 51 patients (18 males and 33 females) aged 25–75 years and presenting with LPR symptoms further confirmed in a laryngovideoscopic examination, were included in the study. Patients were qualified for the study on the basis of reflux symptom index (RSI) of above 13 and reflux finding score (RFS) of above 7. Patients were recommended to use the HA + CS combination product for 14 days and were evaluated after this time. Results: Symptoms suggestive of significant or severe problem (RSI of 4 or 5) before the treatment included: throat clearing (48 patients; 90.19%), hoarseness (29 patients; 56.86%) and cough after eating/cough while lying down (37 patients; 72.50%). After the treatment, patients reported a moderate impact of the above symptoms on their everyday functioning (P < 0.001). Symptoms such as pharyngeal mucus presence, acute cough, sensation of foreign body in the throat, while declared as moderate at baseline (score of 3) resolved to mild (score of 1) following the supportive treatment (P < 0.001). Total RSI after the treatment was assessed as borderline for LPR diagnosis (median 13, range 12–15). Although patients were not completely freed of their reflux symptoms, a significant reduction in symptoms was achieved in the entire study group. Prior to the treatment, the most common morphological changes within the larynx included redness/congestion, vocal fold edema and posterior commissure hypertrophy. These changes were observed in all patients. After the treatment, the RFS fell below the LPR diagnostic threshold (median 6, range 5–7). Compared to baseline values (median 9, range 8–10), significant improvement of laryngeal changes was observed in nearly the entire study group (N = 50; 98.04%) (P < 0.001). Conclusions: The combination product consisting of hyaluronic acid and chondroitin sulfate on a bioadhesive acts locally to significantly reduce laryngopharyngeal reflux symptoms, particularly in patients with chronic cough, throat clearing, and hoarseness. In addition, by lining the laryngeal mucosa with a protective layer, the product facilitates better hydration as well as faster healing and regeneration of the mucosal membrane, thus leading to a reduction or resolution of morphological changes within the larynx.

9

The role of an oral formulation of hyaluonic acid and chondroitin sulphate in the treatment of patients with laryngopharyngeal reflux

75%

Chmielecka-Rutkowska J., Tomasik B., Pietruszewska W.

Otolaryngologia Polska

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2019

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vol. 73(6)

38-49

EN

Introduction: Proton pump inhibitors (PPIs) have become an important breakthrough in the treatment of gastroesophageal reflux disease (GERD). However, in patients with laryngopharyngeal reflux (LPR) – one of the extraesophageal variants of the disease – the efficacy of PPI is incomplete or limited and alleviation of symptoms requires additional medications. As of today, the importance of hyaluronic acid (HA) and chondroitin sulphate (CS) and their role in mucosal damage healing, most particularly within the larynx, is being highlighted. Objective: The objective of the study was to assess the outcomes of treatment in LPR patients receiving a combination of hyaluronic acid and chondroitin sulfate (HA + CS) on a bioadhesive carrier. Material and methods: A total of 51 patients (18 males and 33 females) aged 25–75 years and presenting with LPR symptoms further confirmed in a laryngovideoscopic examination, were included in the study. Patients were qualified for the study on the basis of reflux symptom index (RSI) of above 13 and reflux finding score (RFS) of above 7. Patients were recommended to use the HA + CS combination product for 14 days and were evaluated after this time. Results: Symptoms suggestive of significant or severe problem (RSI of 4 or 5) before the treatment included: throat clearing (48 patients; 90.19%), hoarseness (29 patients; 56.86%) and cough after eating/cough while lying down (37 patients; 72.50%). After the treatment, patients reported a moderate impact of the above symptoms on their everyday functioning (P < 0.001). Symptoms such as pharyngeal mucus presence, acute cough, sensation of foreign body in the throat, while declared as moderate at baseline (score of 3) resolved to mild (score of 1) following the supportive treatment (P < 0.001). Total RSI after the treatment was assessed as borderline for LPR diagnosis (median 13, range 12–15). Although patients were not completely freed of their reflux symptoms, a significant reduction in symptoms was achieved in the entire study group. Prior to the treatment, the most common morphological changes within the larynx included redness/congestion, vocal fold edema and posterior commissure hypertrophy. These changes were observed in all patients. After the treatment, the RFS fell below the LPR diagnostic threshold (median 6, range 5–7). Compared to baseline values (median 9, range 8–10), significant improvement of laryngeal changes was observed in nearly the entire study group (N = 50; 98.04%) (P < 0.001). Conclusions: The combination product consisting of hyaluronic acid and chondroitin sulfate on a bioadhesive acts locally to significantly reduce laryngopharyngeal reflux symptoms, particularly in patients with chronic cough, throat clearing, and hoarseness. In addition, by lining the laryngeal mucosa with a protective layer, the product facilitates better hydration as well as faster healing and regeneration of the mucosal membrane, thus leading to a reduction or resolution of morphological changes within the larynx.

10

BIODEGRADABLE NONWOVEN ACTIVATED POLYESTER WITH CHITOSAN: POTENTIAL APPLICATION IN THE COSMETIC INDUSTRY

75%

Gzyra-Jagieła K., Owczarek M., Szkopiecka M., Jagodzińska S., Dymel M., Kudra-Miros P., Kudra M.

Progress on Chemistry and Application of Chitin and its Derivatives

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2020

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vol. 25

94 - 110

EN

Textile products enriched with natural substances, e.g. hyaluronic acid, plant hydrolates, collagen and chitosan, may find wide application in cosmetics because of increasing consumer interest in natural products. Furthermore, in view of global environmental pollution, products that are produced through biochemical changes as a result of composting are sought. This makes it possible to enter such designed cosmetic products into the scheme of the currently desired circular economy. Compostable textiles are an ecological alternative to product backlogs and polluting the environment in the form of post-consumer waste. Therefore, this research work developed a technology for applying natural substances on a biodegradable polyester fibrous substrate. This study developed the optimal composition of a mixture consisting of natural substances with properties applicable to the cosmetic industry, for applications such as cosmetic masks to improve the appearance of the skin. The composition of active substances that have beneficial effects on the skin, e.g. moisturizing, regenerating, antibacterial and caring, was determined. The mixture was effectively applied on a spunbound nonwoven substrate of made from aliphatic-aromatic copolyester by impregnation. The employed polymer degraded in a compost environment and its modifiers additionally supported this process. The unique composition of the applied coating layer consisted of a mixture of sodium hyaluronate, collagen, bitter orange blossom hydrolate (Neroli) and chitosan lactate. The coated nonwoven fabric was subjected to physical, mechanical, microbiological as well as chemical purity and structural tests (Fourier transform infrared spectroscopy and scanning electron microscopy) and degree of degradation in a compost environment was assessed on the basis of its weight loss.

11

SURFACE CHARACTERISTICS OF DPPC MONOLAYERS DEPOSITED FROM TITANIUM DIOXIDE–CHITOSAN–HYALURONIC ACID SUBPHASES ON A GLASS SUPPORT

75%

Ładniak A., Jurak M., Wiącek A. E.

Progress on Chemistry and Application of Chitin and its Derivatives

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2019

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vol. 24

106 - 118

EN

The Langmuir-Blodgett technique was used to transfer the monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) from the subphase containing chitosan (Ch) and/or titanium(IV) oxide (TiO2) and/or hyaluronic acid (HA) on glass plates after a low-temperature air plasma treatment. The surface free energy and its components were determined on the basis of advancing and receding contact angle measurements of water (W), formamide (F), and diiodomethane (DM). To estimate the total surface free energy (𝛾𝑠𝑡𝑜𝑡), the contact angle hysteresis (CAH) model was used, and the obtained data were compared with the results calculated from the Lifshitz-van der Waals/acid–base (LWAB) approach. It was found that the subphase components modify the surface of the phospholipid monolayer by changing the type and magnitude of interactions. They were reflected as significant differences in the obtained values of total surface free energy and its components. These findings can help in the development of composite materials, thereby expanding the spectrum of applications for chitosan, TiO2, and HA, as well as understanding the interactions between biomaterial and cell.

12

Wiskosuplementacja w chorobie zwyrodnieniowej stawu kolanowego

75%

Ostałowska A. B., Święchowicz S., Koczy B., Stołtny T., Nowak D., Skowron M., Birkner E., Kasperczyk S.

Annales Academiae Medicae Silesiensis

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2017

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vol. 71

38-45

EN

WSTĘP: Choroba zwyrodnieniowa stawów kolanowych (gonartroza – GA) należy do najczęstszych schorzeń narządu ruchu, a ból i ograniczenie ruchomości kolana są najdotkliwiej odbieranymi przez pacjentów objawami zmian zwyrodnieniowych. Celem pracy było sprawdzenie, czy podanie dostawowe preparatu kwasu hialuronowego wpływa na funkcje stawu kolanowego, wybrane parametry układu antyoksydacyjnego i natężenie stresu oksydacyjnego we krwi u pacjentów z gonartrozą. MATERIAŁ I METODY: Grupa badana 1K obejmowała 96 pacjentów z chorobą zwyrodnieniową stawu kolanowego, którym podano kwas hialuronowy do jednego stawu kolanowego, natomiast do grupy badanej 2K włączono 33 pacjentów, którym podano kwas hialuronowy do obu stawów kolanowych. Badanie prowadzono przez 40 tygodni według ustalonego protokołu. Oznaczono całkowity status oksydacyjny (TOS) osocza, zawartość grup sulfhydrylowych (SH) w surowicy, aktywność katalazy (CAT) w erytrocytach, aktywność dysmutazy ponadtlenkowej (SOD) w osoczu i erytrocytach, aktywność peroksydazy glutationowej (GPx) w erytrocytach. WYNIKI: Po leczeniu wiskosuplementacyjnym odnotowano zmniejszenie nasilenia bólu oraz poprawę w badanych skalach VAS i HHS, przy czym nieco większą poprawę stwierdzono w przypadku zajęcia jednego kolana. Po leczeniu dostawowym kwasem hialuronowym stwierdzono znamienny spadek aktywności SOD oraz CAT a wzrost aktywności GPx, wzrost stężenia grup SH w obu grupach oraz spadek stężenia TOS. WNIOSKI: Wiskosuplementacja w chorobie zwyrodnieniowej stawu kolanowego istotnie redukuje ból kolana i poprawia jego funkcje oraz wywołuje korzystne zmiany w układzie antyoksydacyjnym krwi. Efekt leczenia jest porównywalny zarówno w przypadku podawania preparatu kwasu hialuronowego do jednego, jaki i do obu stawów kolanowych.

PL

INTRODUCTION: Osteoarthritis of the knee (gonarthritis – GA) is one of the most common musculoskeletal disorders. Pain and limitation of joint movement are the most constant and troublesome symptoms of the joint pathology. The aim of the study was to examine viscosupplementation therapy with hyaluronic acid. MATERIAL AND METHODS: 96 patients were administered hyaluronic acid unilaterally (the 1K group), while 33 patients were administered hyaluronic acid bilaterally (the 2K group) in a 40-day cycle. The stage of the disease was assessed based on medical history, physical examination and a questionnaire survey. Analysis of the following parameters was performed: serum level of sulfhydryl groups (SH), total oxidant status (TOS), catalase activities (CAT) and glutathione peroxidase (GPx) in erythrocytes and superoxide dismutase activity (SOD) in plasma and erythrocytes. RESULTS: Viscosupplementation resulted in pain reduction and improvement in the HHS score. The SOD and CAT activities were significantly decreased, while GPx activity as well as the SH level significantly increased in both the examined groups. In addition the TOS values significantly decreased. CONCLUSION: Viscosupplementation therapy with hyaluronic acid significantly reduces pain of the knee joint, improves its function and has a beneficial effect on the pro/antioxidant balance in the blood of patients diagnosed with GA. The effects of uni- and bilateral administration of hyaluronic acid are similar.

13

Clinical importance of proper regeneration of the ocular surface after cataract surgery

75%

Izdebska J., Samelska K.

OphthaTherapy

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2024

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vol. 11

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issue 1

69-74

EN

Ophthalmic surgeries, including cataract surgery, lead to higher occurrence of eye surface disease. Tear film abnormalities are present in more than 60% of cataract patients. Patients with increased risk of perioperative dry eye syndrome should be treated before the surgery. Artificial tears are the first line treatment. In case they are insufficient, immunomodulants are used. Eyelid margin hygiene also exerts positive effect in patients with Meibomian gland dysfunction. Out of artificial tears ingredients, hyaluronic acid and Ginkgo biloba extract show positive effect.

14

Wpływ preparatów zawierających hialuroniany na niektóre parametry zaburzeń statyki narządów moczowo-płciowych u kobiet

63%

Markowska J., Sterlińska-Tulimowska B.

Current Gynecologic Oncology

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2016

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vol. 14

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issue 2

97-103

EN

Urogenital organs statics disorders affect approximately 30–75% of women; their incidence increases with age. Among various causes, the generally recognized ones are deliveries experiences in the past, excessive physical effort, age-related estrogen deficiency, previous treatment, including irradiation (brachytherapy) – mainly due to uterine tumors. Dysfunctions in statics usually involve two anatomically and developmentally related systems: the reproductive system and the urinary system. In gynecologic practice, the most common pathologies involve a lowering the anterior vaginal wall (cystocele), stress urinary incontinence and polyuria. Study encompassed 78 women, aged 50 to 76, 11 of whom experienced earlier endometrial cancer and nine of whom were also subjected to brachytherapy. In 63 women OB intravaginal tampons were applied for three months, covered with a gel or cream containing hyaluronic acid; in some of them additionally estriolcontaining ointment was applied twice a week. Some women (15) were exclusively recommended to do the Kegel exercises. Evaluation of stress urinary incontinence as well as polyuria and nocturia was conducted 3 and 6 months after tampons stopped to be applied. The application of tampons covered with hyaluronic acid-containing preparations was found to reduce significantly the symptoms of stress urinary incontinence and polyuria and the symptoms of cystocele. The presented method is simple and evidently effective.

PL

Zaburzenia statyki narządów moczowo-płciowych dotyczą 30–75% kobiet, a częstość tych zmian wzrasta z wiekiem. Wśród różnych przyczyn problemu powszechnie wymienia się porody, nadmierny wysiłek fizyczny, niedobór estrogenów związany z wiekiem i przebyte leczenie, w tym napromienianie (brachyterapię) – głównie z powodu nowotworów macicy. Dysfunkcje statyki dotyczą zwykle dwóch anatomicznie i rozwojowo powiązanych układów: płciowego i moczowego. W praktyce ginekologicznej najczęściej spotykanymi zmianami są obniżenie przedniej ściany pochwy (cystocele), wysiłkowe nietrzymanie moczu i częste oddawanie moczu. Badaniem objęto 78 kobiet w wieku 50–76 lat, z których 11 chorowało na raka endometrium (dziewięć z nich przeszło brachyterapię). U 63 pacjentek stosowano przez 3 miesiące tampony dopochwowe OB pokryte żelem lub kremem zawierającym kwas hialuronowy, a u części z nich – dodatkowo dwa razy w tygodniu maść z estriolem. Niektórym kobietom (15) zlecono wyłącznie ćwiczenia Kegla. Ocenę wysiłkowego, częstego i nocnego oddawania moczu przeprowadzono po 3 i 6 miesiącach od zaprzestania używania tamponów. Stosowanie tamponów pokrytych preparatami zawierającymi kwas hialuronowy istotnie zmniejsza objawy wysiłkowego i częstego oddawania moczu, a także objawy cystocele. Przedstawiona metoda jest prosta i w znacznej mierze skuteczna.

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Artificial skin composites

CHARACTERISATION OF CHITOSAN/HYALURONIC ACID BLEND FILMS MODIFIED BY COLLAGEN

INFLUENCE OF THE INTERMOLECULAR INTERACTION ON PHYSICO-CHEMICAL PROPERTIES OF CHITOSAN/HYALURONIC ACID BLENDS

Elevated level of ambient glucose stimulates the synthesis of high-molecular-weight hyaluronic acid by human mesangial cells. The involvement of transforming growth factor β1 and its activation by thrombospondin-1

THE INFLUENCE OF THE TYPE SOLVENT ON THE STRUCTURE OF CHITOSAN BLENDS WITH HYALURONIC ACID

Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in children with non-alcoholic fatty liver disease

The role of serum hyaluronic acid determination in the diagnosis of liver fibrosis

The role of an oral formulation of hyaluonic acid and chondroitin sulphate in the treatment of patients with laryngopharyngeal reflux

The role of an oral formulation of hyaluonic acid and chondroitin sulphate in the treatment of patients with laryngopharyngeal reflux

BIODEGRADABLE NONWOVEN ACTIVATED POLYESTER WITH CHITOSAN: POTENTIAL APPLICATION IN THE COSMETIC INDUSTRY

SURFACE CHARACTERISTICS OF DPPC MONOLAYERS DEPOSITED FROM TITANIUM DIOXIDE–CHITOSAN–HYALURONIC ACID SUBPHASES ON A GLASS SUPPORT

Wiskosuplementacja w chorobie zwyrodnieniowej stawu kolanowego

Clinical importance of proper regeneration of the ocular surface after cataract surgery

Wpływ preparatów zawierających hialuroniany na niektóre parametry zaburzeń statyki narządów moczowo-płciowych u kobiet