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1

Therapeutic activity of chlorhexidine-poloxamer antiseptic gel on wound healing in rats: a preclinical study

100%

Babickaite L., Grigonis A., Ramanauskiene K., Matusevicius A. P., Zamokas G., Daunoras G., Ivaskiene M.

Polish Journal of Veterinary Sciences

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2018

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vol. 21

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issue 1

2

Wound healing – characteristics of the ideal dressing

100%

Orlińska K., Komosińska-Vassev K., Olczyk K., Glaesel M., Olczyk P.

Annales Academiae Medicae Silesiensis

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2023

|

issue 77

197-203

EN

Wound healing is a dynamic process aimed at restoring homeostasis and functionality of damaged tissue. It is a highly complex, multi-stage process, the disruption of which leads to complications and health problems for the injured person. The discussed process takes place in the human system in two ways. The first of them is granulation and the second is healing per primary. Regardless of the method of wound healing, the individual phases of this process overlap each other, where before the end of the previous phase, the next begins. Demarcation of individual phases is purely practical. There are four phases of healing: the hemostasis phase, the inflammation phase, the proliferative phase – in other words the replication and synthesis phase – and the remodeling phase. The process of wound healing is a natural, long-term, and complex process that occurs in the body when injured. Incorrect healing may result in chronic wounds, necrosis or excessive scarring. Wound treatment supports this naturally occurring process in the body. In cases that require such support dressings are used, which are an essential element applicable in health care. An ideal dressing should create a barrier against external factors, maintain an appropriate environment in the wound bed (appropriate temperature, optimal humidity, slightly acidic pH, gas exchange), absorb excess of blood and exudate, keep the wound clean – cleanse it of necrotic tissue and toxins – do not adhere to the wound to avoid wound damage during dressing replacement, do not show sensitizing or irritating effects.

PL

Gojenie się ran to proces dynamiczny, którego celem jest przywrócenie homeostazy oraz funkcjonalności usz-kodzonej tkanki. To wysoce złożony, wieloetapowy proces, którego zaburzenie prowadzi do powikłań i prob-lemów zdrowotnych osoby poszkodowanej. Omawiany proces przebiega w ustroju ludzkim dwiema drogami. Pierwszą z nich jest ziarnino-wanie, drugą rychłozrost. Niezależnie od sposobu gojenia się rany, poszczególne fazy tego procesu wzajemnie nachodzą na siebie, gdzie przed zakończeniem fazy poprzedniej rozpoczyna się następna. Rozgraniczenie poszczególnych faz ma charakter czysto praktyczny. Wyróżnia się cztery fazy go-jenia: fazę hemostazy, fazę zapalenia, fazę proliferacyjną – inaczej fazę replikacji i syntezy – oraz fazę re-modelingu. Proces gojenia się ran jest procesem naturalnie zachodzącym w organizmie, długotrwałym i złożonym, który zachodzi w przypadku zranienia. Nieprawidłowy przebieg gojenia może skutkować wystąpieniem ran przewle-kłych, martwic czy nadmiernego bliznowacenia. Wspomaganiem tego naturalnie zachodzącego w organizmie procesu jest leczenie ran. W przypadkach wymagających takiego wsparcia stosuje się opatrunki, które są elementem niezbędnym, mającym zastosowanie w ochronie zdrowia. Idealny opatrunek powinien: tworzyć barierę przed czynnikami zewnętrznymi, utrzymywać odpowiednie środowisko w łożysku rany (odpowiednia temperatura, wysoka wilgotność, lekko kwaśne pH, umożliwienie wymiany gazowej), absorbować nadmiar krwi oraz wysięku, utrzymywać ranę w czystości – oczyszczać z tkanki martwiczej i toksyn – nie przywierać do rany, aby uniknąć jej uszkodzenia w trakcie wymiany opatrunku, nie wykazywać działania uczulającego, a także drażniącego.

3

Wound healing – characteristics of the ideal dressing

100%

Orlińska K., Komosińska-Vassev K., Olczyk K., Glaesel M., Olczyk P.

Annales Academiae Medicae Silesiensis

|

2023

|

issue 77

PL

Gojenie się ran to proces dynamiczny, którego celem jest przywrócenie homeostazy oraz funkcjonalności uszkodzonej tkanki. To wysoce złożony, wieloetapowy proces, którego zaburzenie prowadzi do powikłań i problemów zdrowotnych osoby poszkodowanej. Omawiany proces przebiega w ustroju ludzkim dwiema drogami. Pierwszą z nich jest ziarnino-wanie, drugą rychłozrost. Niezależnie od sposobu gojenia się rany, poszczególne fazy tego procesu wzajemnie nachodzą na siebie, gdzie przed zakończeniem fazy poprzedniej rozpoczyna się następna. Rozgraniczenie poszczególnych faz ma charakter czysto praktyczny. Wyróżnia się cztery fazy gojenia: fazę hemostazy, fazę zapalenia, fazę proliferacyjną – inaczej fazę replikacji i syntezy – oraz fazę remodelingu. Proces gojenia się ran jest procesem naturalnie zachodzącym w organizmie, długotrwałym i złożonym, który zachodzi w przypadku zranienia. Nieprawidłowy przebieg gojenia może skutkować wystąpieniem ran przewlekłych, martwic czy nadmiernego bliznowacenia. Wspomaganiem tego naturalnie zachodzącego w organizmie procesu jest leczenie ran. W przypadkach wymagających takiego wsparcia stosuje się opatrunki, które są elementem niezbędnym, mającym zastosowanie w ochronie zdrowia. Idealny opatrunek powinien: tworzyć barierę przed czynnikami zewnętrznymi, utrzymywać odpowiednie środowisko w łożysku rany (odpowiednia temperatura, wysoka wilgotność, lekko kwaśne pH, umożliwienie wymiany gazowej), absorbować nadmiar krwi oraz wysięku, utrzymywać ranę w czystości – oczyszczać z tkanki martwiczej i toksyn – nie przywierać do rany, aby uniknąć jej uszkodzenia w trakcie wymiany opatrunku, nie wykazywać działania uczulającego, a także drażniącego.

EN

Wound healing is a dynamic process aimed at restoring homeostasis and functionality of damaged tissue. It is a highly complex, multi-stage process, the disruption of which leads to complications and health problems for the injured person. The discussed process takes place in the human system in two ways. The first of them is granulation and the second is healing per primary. Regardless of the method of wound healing, the individual phases of this process overlap each other, where before the end of the previous phase, the next begins. Demarcation of individual phases is purely practical. There are four phases of healing: the hemostasis phase, the inflammation phase, the proliferative phase – in other words the replication and synthesis phase – and the remodeling phase. The process of wound healing is a natural, long-term, and complex process that occurs in the body when injured. Incorrect healing may result in chronic wounds, necrosis or excessive scarring. Wound treatment supports this naturally occurring process in the body. In cases that require such support dressings are used, which are an essential element applicable in health care. An ideal dressing should create a barrier against external factors, maintain an appropriate environment in the wound bed (appropriate temperature, optimal humidity, slightly acidic pH, gas exchange), absorb excess of blood and exudate, keep the wound clean – cleanse it of necrotic tissue and toxins – do not adhere to the wound to avoid wound damage during dressing replacement, do not show sensitizing or irritating effects.

4

Influence of antlerogenic stem cells on the healing of lesions in the corneal epithelium and corneal stroma in rabbits

100%

Kiełbowicz M., Kuropka P., Cegielski M., Kiełbowicz Z., Trębacz P., Hebel M., Aleksiewicz R., Kiełbowicz M., Kuropka P., Cegielski M., Kiełbowicz Z., Trębacz P., Hebel M., Aleksiewicz R.

Polish Journal of Veterinary Sciences

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2020

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vol. 23

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issue 2

5

Immediate and Delayed Surgical Repair of Duodenal Defects in Rats with Small Intestinal Submucosa Patch

100%

Miliaras D., Miliaras S., Meditskou S., Papamitsou T.

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vol. 86

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issue 3

116-121

EN

Duodenal injuries, though rare, carry high rates of morbidity and mortality. The aim of the study was to evaluate the healing of the duodenal wall with the use of a Small Intestinal Submucosa (SIS) patch. Material and methods. We studied 40 Whistar-Albino rats divided into two groups. In group A, we created a small defect in the duodenal wall, which was immediately covered with a SIS patch. In group B, the SIS patch was sutured over the defect after 6-8 hours, in order to induce peritonitis. The animals of both groups were sacrificed after 2, 6, 12 and 16 weeks respectively. In addition, we studied the immunohistochemical expression of TGF-β, which is a major constituent of SIS, and plays a central role in the healing process. Results. Histology showed progressive development of the layers of the duodenal wall over the patch as early as the 2nd week in some of the animals of group A. Mucosa developed later on in the animals of group B, presumably due to the more intense inflammation elicited by peritonitis. Expression of TGF-β was initially more pronounced in the epithelial cells of the regenerating mucosa of animals of group A, but it was maintained in higher levels in the animals of group B, which showed delayed mucosa degeneration. Conclusions. SIS appears to be both efficient and safe for the management of duodenal trauma. TGF-β seems to play an important role in the healing process, inducing regeneration of the stroma, and controling epithelial growth.

6

Proliferation and Ability for Epidermal Autoregeneration in Patients with Chronic Lower Leg Venous Ulcerations

100%

Waligóra J., Noszczyk B.

Polish Journal of Surgery

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2007

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vol. 79

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issue 2

113-119

EN

The protein p63 plays a significant role in the development of animal epithelium. p63 is a regulator of differentiation, senescence and adhesion programs in numerous mature epithelial tissues. In patients with a healthy epidermis, p63 maintains cell progenitor potential - the ability for cellular division to occur using the delayed differentiation program. It is also responsible for the protecting the epithelial phenotype from depletion in migrating cells, thus resulting in invasion and infiltration after altering its endogenous expression.The aim of the study was to compare the number of cells with p63 protein expression and the presence of Ki67 proliferation marker in the epidermis in patients with chronic venous ulcerations versus those with properly healing wounds.Material and methods. Study materials were comprised of biopsy samples collected from healthy volunteers and patients treated for venous ulcerations. The specimens were subjected to immunohistochemical staining using available monoclonal antibodies and were analyzed with an imaging analysis program which evaluated the expression indices of both proteins in areas of intensified cellular division, i.e. wound edges.Results. The number of cells displaying protein expression in patients with chronic venous ulcerations was significantly lower in comparison to the values observed in healthy volunteers. This was determined during the intermediary phase of wound healing, the most pronounced phase of cellular response to injury.Conclusions. Decreased epidermal p63 expression in patients with venous ulcerations suggests insufficient protein production for the maintenance of autoregeneration and long-lasting division; both are required for the supplementation of migrating cells. The above-mentioned phenomenon suggests that there may be a role for p63 in regulation of the healing process and pathophysiology of chronic venous leg ulcerations.

Refine search results

Therapeutic activity of chlorhexidine-poloxamer antiseptic gel on wound healing in rats: a preclinical study

Wound healing – characteristics of the ideal dressing

Wound healing – characteristics of the ideal dressing

Influence of antlerogenic stem cells on the healing of lesions in the corneal epithelium and corneal stroma in rabbits

Immediate and Delayed Surgical Repair of Duodenal Defects in Rats with Small Intestinal Submucosa Patch

Proliferation and Ability for Epidermal Autoregeneration in Patients with Chronic Lower Leg Venous Ulcerations