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The use of pesticides has been a catalyst that improves crop quality and yield. It can be designed using conventional or modern technologies depending on the type of pesticides being used. It is used to prevent organisms that are considered to be harmful to crop growth and development by protecting them from pests and diseases, thus increasing food crop’s quality. There are several classifications of pesticides among which are; insecticides, fungicides, rodenticides, etc. Physicochemical and biological methods are the basic two ways of detecting pesticide poisoning. Immunoassays (biological) are the most prominent methods of detection, it requires the use of fluorescent, chemiluminescent or other detection methods to detect drugs, proteins, and some hormones. Pesticide residues are responsible for environmental pollution such as groundwater contamination, global warming and killing non-target organisms in the soil. Exposing the human body to excess pesticide residue can lead to various severe health conditions such as cancer, asthma, etc. The metabolism of pesticides in the body system undergoes two stages, namely; phase one and phase two. oxidation reactions occur in phrase one whereby pesticides functional groups are majorly synthesized by Cytochrome P450 enzymes. Phase two includes the reactions of phase I substrate with glucuronic acid (C6H10O7), tetraoxosulphate(VI) acid (H2SO4), ethanoic acid (CH3COOH), etc. to form more polar compounds for easy excretion. The introduction of inexpensive biodegradable pesticides and the enforcement and implementation of pesticide control and regulation laws has helped to decrease the negative effects of pesticide residue in humans and the surroundings. Pesticide residue can be eliminated or reduced from food crops by practicing organic farming, washing, and food product processing, natural pesticide application, and rational use of pesticides. It is highly recommended to follow the prescription of pesticides used to avoid its toxicity in the biological systems.
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