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MRI as a potential tool for monitoring of therapeutic monoclonal antibody distribution in cancer patients

100%
Tabarkiewicz J., Aebisher D., Bartusik-Aebisher D.
Acta Poloniae Pharmaceutica - Drug Research
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2020
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vol. 77
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issue 3
383-389
EN
Imaging and quantification of MAbs distribution by MRI after administration in vivo can improve patient outcomes, although it is not routinely used in the clinic hence the motivation for development of new MAbs imaging methodologies. Improvements in imaging and quantification of antibody distributions can be made by conjugating MAbs to “hotspot” atoms such as 19F as 19F Currently, research investigating the incorporation of 19F to antibody delivery systems has been limited to trastuzumab perfluorocarbon emulsions and this method has not been extended to other clinically approved antibodies. The methodologies of 19F MRI can improve current limitations of antibody immunotherapy such as quantitative visualization of targeted surface antigens expressed on tumor cells.
2
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Environmental aspects of feed phosphates production

100%
Hoffmann J., Hoffmann K., Borowiec M., Huculak M.
Polish Journal of Chemical Technology
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2009
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vol. 11
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issue 1
16-19
EN
The risks resulting from the selected feed phosphates application in animal nutrition were analyzed. The results of the analyses of the fodder phosphates obtained in laboratory conditions were presented, including the toxic and disadvantageous substances with regard to their impact upon the environment.
3
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Processes occurring in the soil and fluorine

75%
Xiajin W., Finbin X., Aoshan Y.
World News of Natural Sciences
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2017
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vol. 8
37-42
EN
Fluorine is in the dynamic balance of two geochemical processes, enrichment and leaching. These reflect the adsorption and desorption of fluoride by clay minerals, respectively. The two geochemical processes of fluorine in soil are influenced by interacting factors, including the geochemical characteristics of soil and clay minerals, pH and sanity of soil solutions, climate, grazing and agriculture activities.
4
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Fluorine in ornithogenic soils and minerals on King George Island, West Antarctica

75%
Tatur A., Tatur A.
Polish Polar Research
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1987
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vol. 8
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issue 1
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