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Evaluation of the Levels of Metalloproteinsase-2 in Patients with Abdominal Aneurysm and Abdominal Hernias

100%

Antoszewska M.

Polish Journal of Surgery

2013

vol. 85

issue 5

271-278

Abdominal aortic aneurysms and abdominal hernias become an important health problems of our times. Abdominal aortic aneurysm and its rupture is one of the most dangerous fact in vascular surgery. There are some theories pointing to a multifactoral genesis of these kinds of diseases, all of them assume the attenuation of abdominal fascia and abdominal aortic wall. The density and continuity of these structures depend on collagen and elastic fibers structure. Reducing the strengthof the fibersmaybedue to changes in the extracellular matrix (ECM) by the proteolytic enzymes-matrix metalloproteinases (MMPs) that degrade extracellular matrix proteins. These enzymes play an important role in the development of many disease: malignant tumors (colon, breast, lung, pancreas), cardiovascular disease (myocardial infarction, ischemia-reperfusion injury), connective tissue diseases (Ehler-Danlos Syndrome, Marfan’s Syndrome), complications of diabetes (retinopathy, nephropathy). One of the most important is matrix metalloproteinase-2 (MMP-2). The aim of the study was an estimation of the MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia, and in patients with only abdominal aortic aneurysm. Material and methods. The study involved 88 patients aged 42 to 89 years, including 75 men and 13 women. Patients were divided into two groups: patients with abdominal aortic aneurysm and primary abdominal hernia (45 persons, representing 51.1% of all group) and patients with only abdominal aortic aneurysm (43 persons, representing 48,9% of all group). Results. It was a statistically significant increase in MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia compared to patients with only abdominal aortic aneurysm. It was a statistically significant increase in the prevalence of POCHP in patients with only abdominal aortic aneurysm compared to patients with abdominal aortic aneurysm and primary abdominal hernia. Conclusions. Statistically significant higher MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia seems shows that this enzyme plays a role in the pathogenesis of primary abdominal hernias. The observed distribution of MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia may raise the conclusion that this enzyme determines the presence of multi-organ failure of the connective tissue - the patients with only abdominal aortic aneurysm had significantly lower MMP-2 blood levels.

Funkcjonalny zespół górnego otworu klatki piersiowej

58%

Godek P., Ruciński W., Brzuszkiewicz-Kuźmicka G.

Advances in Rehabilitation

2018

vol. 31

issue 3

71-86

Thoracic Outlet Syndrome (TOS) is one of the most controversial compression (vascular and neurogenic) syndromes both due to the fact it is difficult to diagnose and because of the lack of generally accepted standard procedures. It is estimated that this condition occurs in 10 out of 100 000 people, while clinical examinations reveal that arterial symptoms are more common than neurogenic ones. This work presents a pathogenesis of the functional type of the syndrome with regard to contemporary studies analysing the effects of currently applied forms of conservative treatment. The study presents arguments concerning the significance of proper diagnosis which makes it possible to individualise the therapy according to current trends in rehabilitation mentioned in the available literature and resulting from the authors’ own experience.

Zespół Górnego Otworu Klatki Piersiowej (Thoracic Outlet Syndrom, TOS) jest jednym z najbardziej kontrowersyjnych mieszanych zespołów uciskowych (naczyniowo-nerwowych) zarówno ze względu na trudności diagnostyczne jak i brak ogólnie przyjętych standardowych algorytmów postępowania. Ocenia się, iż ta jednostka chorobowa występuje u 10 na 100 000 osób, a w obrazie klinicznym odnotowuje się przewagę objawów naczyniowych nad neurogennymi. W pracy przedstawiono patogenezę funkcjonalnej odmiany zespołu uwzględniając współczesne doniesienia związane z efektami obecnie podejmowanych kierunków postępowania leczenia zachowawczego. Przytoczono argumentację dotyczącą znaczenia poprawnej diagnostyki i wynikającej z niej możliwości zindywidualizowania terapii zgodnej z aktualnie preferowanymi kierunkami postępowania rehabilitacyjnego funkcjonującymi w dostępnej literaturze, jak również wynikającej z własnych wieloletnich doświadczeń.

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1 Advances in Rehabilitation

1 Polish Journal of Surgery

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1 Antoszewska M.

1 Brzuszkiewicz-Kuźmicka G.

1 Godek P.

1 Ruciński W.

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Evaluation of the Levels of Metalloproteinsase-2 in Patients with Abdominal Aneurysm and Abdominal Hernias

Funkcjonalny zespół górnego otworu klatki piersiowej