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Evaluation of Endostatin and EGF Serum Levels in Patients with Gastric Cancer

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Masiak W., Szponar A., Chodorowska G., Dąbrowski A., Pedowski T., Wallner G.

Polish Journal of Surgery

2011

vol. 83

issue 1

42-47

The aim of the study was to assess angiogenesis markers - endostatin and endothelial growth factor (EGF) as markers of detection of gastric carcinoma.Material and methods. The study involved 20 patients with colorectal cancer (10 women, 10 men) aged 35 - 75 years, mean age = 55 years ± 11.2 who referred to the 2nd Department of General Surgery, Medical University in Lublin between June 2008 and June 2009. The control group comprised 10 volunteers (6 women, 4 men) who underwent upper gastrointestinal (GI) endoscopy due to the reflux disease and in whom gastric cancer was not diagnosed.Results. The mean endostatin concentration in controls was 5.21 ng/mL ± 1.37. Mean concentrations in patients with gastric cancer were higher than those in controls - 5.91 ng/mL ± 1.5. The difference was not statistically significant (p= 0.714). The EGF concentration in the control group was 28.19 pg/mL ± 12.94. EGF concentrations in patients with gastric cancer were higher compared to the control group - 28.8 pg/mL ± 12.63. The difference was not statistically significant (p= 0.85). The mean concentration of endostatin before the operation was 5.91 ng/mL ± 1.5 and after surgery was 5.33 ng/mL ± 2.01, the difference was not statistically significant.Conclusions. Blood endostatin and EGF quantitative determinations probably is not useful for detection of gastric carcinoma and effectiveness of treatment.

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1 Polish Journal of Surgery

1 2011

1 Chodorowska G.

1 Dąbrowski A.

1 Masiak W.

1 Pedowski T.

1 Szponar A.

1 Wallner G.

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Evaluation of Endostatin and EGF Serum Levels in Patients with Gastric Cancer