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1

Compressional, mechanical and release properties of a novel gum in paracetamol tablet formulations

100%

Adedokun M. O., Ayorinde J. O., Odeniyi M. A.

Current Issues in Pharmacy and Medical Sciences

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2014

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vol. 27

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issue 3

187-194

EN

The binding properties of Eucalyptus gum obtained from the incised trunk of Eucalyptus tereticornis, were evaluated in paracetamol tablet formulations, in comparison with that of Gelatin B.P. In so doing, the compression properties were analyzed using density measurements and the compression equations of Heckel, Kawakita and Gurham. In our work, the mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets, while the drug release properties of the tablets were assessed using disintegration and dissolution times. The results of the study reveal that tablet formulations incorporating Eucalyptus gum as binder, exhibited faster onset and higher amount of plastic deformation during compression than those containing gelatin. What is more, the Gurnham equation could be used as a substitute for the Kawakita equation in describing the compression properties of pharmaceutical tablets. Furthermore, the crushing strength, disintegration and dissolution times of the tablets increased with binder concentration, while friability values decreased. We noted that no significant differences in properties exist between formulations derived from the two binders (p > 0.05) exist. While tablets incorporating gelatin exhibited higher values for mechanical properties, Eucalyptus gum tablets had better balance between mechanical and release properties - as seen from the CSFR/Dt values. Tablets of good mechanical and release properties were prepared using Eucalyptus gum as a binder, and, therefore, it could serve as an alternative binder in producing tablets with good mechanical strength and fast drug release.

2

Determination of diffusion coefficient and permeability through the barrier of substance in simulated biomedical systems

88%

Adach A., Kister N., Skassa A., Bugalska A.

Chemical and Process Engineering

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2017

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vol. 38

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issue 4

3

KINETICS OF ACTIVE SUBSTANCE RELEASE FROM FLAT BIOPOLYMER MULTILAYER FILMS

88%

Michalak I., Traczyk D., Mucha M.

Progress on Chemistry and Application of Chitin and its Derivatives

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2010

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vol. 15

107 - 116

EN

Abstract. Polymer films were made of different biodegradable materials. Solid support of model active substance (salicylic acid) was unmodified and modified (crosslinked with glutaraldehyde) chitosan and outside layers were polylactid acid (PLA). The aim of the study was to obtain the controlled release kinetics of active substance, in medium of pH 5.6 which is similar to conditions occurring on the human skin surface. The chitosan films were investigated with swelling kinetics while multilayer films were studied with release kinetics of active substance (salicylic acid). The amount of salicylic acid released from film was measured using a UV-VIS spectrophotometer. The appropriate mathematical model was also adjusted to the experimental points. The results prove that the swelling process follows the first order kinetics but the results of release process are fitted with Peppas model.

4

ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE

88%

Gadziński P., Froelich A., Kowalska U., Soból M., Szybowicz M., Osmałek T.

Acta Poloniae Pharmaceutica - Drug Research

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2020

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vol. 77

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issue 2

319-330

EN

The aim of the work was to investigate the properties of polysaccharide matrices loaded with roxithromycin (ROX), made on the basis of low-acyl gellan and its blends with sodium alginate, pectin, karaya gum, methycellulose and κ-carageenan. The obtained formulations were investigated as potential oral dosage forms with the ability to protect it from the acidic conditions of the stomach. Another desired feature of the obtained systems was the sustained release of the active ingredient allowing for potential shifting the therapeutic effect to the colon. The morphology of the matrices was evaluated with optical and scanning electron microscopy. Moreover, Raman spectroscopy and thermal analysis were performed for ROX, polymers, ROX/polymers physical mixtures and the matrices. Next, the swelling behavior was examined. The matrices were evaluated for ROX content and encapsulation efficiency. The last stage concerned the drug release studies. All matrices after production revealed more or less oval shape with visible deformation most probably occurring during drying. Raman analysis and DSC confirmed the crystalline form of ROX and showed no evidence of interactions between the drug and the excipients. It was shown that the matrices containing gellan combined with methylcellulose or κ-carageenan at pH=7.4 released ROX slower than the other matrices which might be promising in terms of colonic drug delivery. Moreover, the polymer matrices remained physically stable at acidic pH similar to the environment of the stomach. However, in these conditions drug degradation was observed which indicates the necessity to further modify the applied technology.

5

CHARACTERISTICS OF ASCORBIC ACID RELEASE FROM TPP-CROSSLINKED CHITOSAN/ALGINATE POLYELECTROLYTE COMPLEX MEMBRANES

75%

Gierszewska M., Ostrowska-Czubenko J., Chrzanowska E.

Progress on Chemistry and Application of Chitin and its Derivatives

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2018

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vol. 23

76 - 87

EN

Chitosan/alginate polyelectrolyte complex membranes (Ch/Alg) additionally cross-linked with tripolyphosphate (TPP) and containing ascorbic acid (AA) were prepared. The dynamic swelling behaviour of Ch/Alg/TPP and ascorbic acid release from the membrane were characterised in different buffer solutions. It has been found that the pH of the buffer solution affects the swelling and release behaviour of AA. Ascorbic acid release, observed over a period of 360 min, exhibited a biphasic pattern, characterised by a fast initial burst release, followed by a slow, sustained release. Different mathematical models were used to study the kinetics and transport mechanism of AA from Ch/Alg/TPP hydrogels. Drug release data were fitted to the zero order kinetic model and first order kinetic model. To characterise the drug mechanism, the release data were fitted to the Higuchi and Korsmeyer-Peppas equations. The initial burst AA release followed zero order kinetics and was quasi-Fickian in nature. The second step of AA release followed first order kinetics.

6

Biocomputing, Biosensing and Bioactuation Based on Enzyme Biocatalyzed Reactions

75%

Mailloux S., Katz E.

Biocatalysis

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2014

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vol. 1

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issue 1

EN

The focus of this review paper is on the design and implementation of smart ‘Sense-and-Treat’ systems using enzyme-biocatalytic systems. These systems were used to perform biomolecular computing and they were functionally integrated with signal responsive materials aiming towards their biomedical use. Electrode interfaces, functionalized with signal-responsive materials, find applications in biocomputing, biosensing, and, specifically, triggered release of bioactive substances. ‘Sense-and-Treat’ systems require multiple components working together, including biosensors, actuators, and filters, in order to achieve closed-loop and autonomous operation. In general, biochemical logic networks were developed to process single biochemical or chemical inputs as well as multiple inputs, responding to nonphysiological (for concept demonstration purposes) and physiological signals (for injury detection or diagnosis). Actuation of drug-mimicking release was performed using the responsive material iron-cross-linked alginate with entrapped biomolecular species, responding to physical, chemical or biochemical signals.

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2 Progress on Chemistry and Application of Chitin and its Derivatives

1 Acta Poloniae Pharmaceutica - Drug Research

1 Biocatalysis

1 Chemical and Process Engineering

1 Current Issues in Pharmacy and Medical Sciences

1 2020

1 2018

1 2017

2 2014

1 2010

1 Adach A.

1 Adedokun M. O.

1 Ayorinde J. O.

1 Bugalska A.

1 Chrzanowska E.

1 Froelich A.

1 Gadziński P.

1 Gierszewska M.

1 Katz E.

1 Kister N.

1 Kowalska U.

1 Mailloux S.

1 Michalak I.

1 Mucha M.

1 Odeniyi M. A.

1 Osmałek T.

1 Ostrowska-Czubenko J.

1 Skassa A.

1 Soból M.