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EN
The World Health Organisation's rationale for physical activity draws heavily on scientific evidence regarding disease and obesity. Greater philosophical reflection on such concepts, along with a recognition that supposed scientific facts are rarely value-free, allow for a more positive and considered argument for physical activity and its benefits. Olympism, Olympic culture, sports education, pedagogy of sport
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Heme oxygenase-1 expression in disease states.

88%
EN
Heme oxygenase-1 (HO-1) is an enzyme which catalyzes the rate-limiting step in heme degradation resulting in the formation of iron, carbon monoxide and biliverdin, which is subsequently converted to bilirubin by biliverdin reductase. The biological effects exerted by the products of this enzymatic reaction have gained much attention. The anti-oxidant, anti-inflammatory and cytoprotective functions associated with HO-1 are attributable to one or more of its degradation products. Induction of HO-1 occurs as an adaptive and beneficial response to several injurious stimuli including heme and this inducible nature of HO-1 signifies its importance in several pathophysiological disease states. The beneficial role of HO-1 has been implicated in several clinically relevant disease states involving multiple organ systems as well as significant biological processes such as ischemia-reperfusion injury, inflammation/immune dysfunction and transplantation. HO-1 has thus emerged as a key target molecule with therapeutic implications.
EN
Honey is the focus of many research projects for its varied biological activities. It is an age-old remedy that is currently being rediscovered as a complementary and alternative medicine (CAM) to be used in modern medicine. The present study aims to investigate the use and perception of honey as CAM among the general public in Ibadan metropolis. A cross sectional study was conducted using three local government areas in Ibadan, a structured and tested questionnaire was then adopted with readjustment. A total of 405 questionnaires were randomly distributed within the study area. These indicate that 63.5% (257/405) of the respondents used honey as CAM, and age significantly affects the usage/ none usage of honey in the study area (p < 0.05). Many respondents claimed they use honey as a dietary supplement for general well-being (79%, 203/257), or for treating burns/wounds (76.3, 196/257), cough (72.8%, 187/257) and sore throat (60.3%, 155/257). A small percentage of the respondents used honey to treat ulcers (17.1%, 44/257). Our work also revealed that a limited number of the respondents (13%, 32/257) buy honey from pharmaceutical stores, while information regarding honey was majorly gotten from friends and family (70%, 180/257). In addition, respondents have favourable perception of the use of honey as CAM - as over 60% of them rated strongly agree and agree for each of the perception question. Respondents highlighted some risk factors affecting the use of honey as CAM, Among which inadequate information on the use of honey ranked highest (mean = 4.40), concerns were also raised on the quality (mean = 4.33) and high price of honey used (4.31). There are favourable perception of the use of honey as CAM, but issues relating to honey quality should be determined before use. Future work should be done to test the perception and acceptance level of honey as CAM among health workers.
EN
It can be said that the it is the most optimistic fact that human being although feels the effect of aging on his body, can have the way of thinking always open on the eternity – what keeps his soul in everlasting youth. We all ¬professors, priests doctors, nurses, parents, teachers, and students can build new social conscience about the importance of old. The old that can be understand as the capital of wisdom of our nation, internal guide, living link to the past, guardian for the young people… Modern men living in the world of thousands meanings have to wait many years or even generations to understand what the most important thing to him is… Although old people frequently need physical help from the young they can help the young to find their road through life. Building bridges between new and old generation.
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63%
Kosmos
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2017
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vol. 66
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issue 2
153-166
PL
Autofagia jest procesem fizjologicznym zachodzącym u eukariontów (rośliny, grzyby i zwierzęta), polegającym na degradacji różnych składników komórki rozpoznanych jako uszkodzone lub zbędne. W zasadzie, każdy proces prowadzący do przekazania materiału komórkowego lizosomom należy uważać za autofiagię. W zjawisku kontrolowanej autodestrukcji lizosomy pełnią rolę komórkowego "zakładu oczyszczania i utylizacji odpadów". W pewnym uproszczeniu można uznać, że autofagia jest dla komórki "sprzątaczką" z umiejętnością recyklingu. Pomimo że o autofagii wiedziano już w latach 60. ubiegłego wieku, rodzaje autofagii (mikro-, makro- i autofagia zależna od białek opiekuńczych) oraz przebieg i mechanizmy sprawcze zostały poznane i szczegółowo opisane dopiero po wprowadzeniu nowych technik biologii molekularnej w czym szczególnie zasłużył się Yoshinori Ohsumi, uhonorowany w roku 2016 Nagrodą Nobla z Fizjologii lub Medycyny. Obecnie wiadomo, że autofagia nadzoruje ważne fizjologiczne funkcje, ale nabiera szczególnego znaczenia w warunkach stresu komórkowego, kiedy dochodzi do uszkodzenia komórki. Taka sytuacja ma miejsce w stanach chorobowych, przy czym wiele obserwacji zebranych od chorych i dane doświadczalne wskazują nieprawidłowo działającą autofagię jako przyczynę choroby.
EN
Autophagy is a physiological process found in eukariotes (plants, fungi, and animals) in which different cellular constituents identified as damaged or obsolete are degraded. In principle, every process of trafficking cell components into the lysosomes should be regarded as autophagy. In the progressive and controlled autodestruction the lysosomes represent waste disposal and recycling centre. Truthfully, autophagy could be considered a "housekeeper" with recycling capability. Alhough autophagy is known from early sixties of the last century, individual forms of autophagy (micro-, makro-, and chaperone-mediated autophagy, CMA) as well as precise course was not described in details unless molecular biology techniques were applied, for which Yoshinori Ohsumi was honoured with Nobel Prize in Physiology or Medicine in 2016. Nowadays, it is widely accepted that autophagy controls important physiological functions where cellular components need to be degraded and recycled, and it is even more important in stress conditions, when cells undergo damage. Such situations come up in diseases, moreover a great deal of observations obtained from sick individuals as well as experimental data confirm abnormal autophagy as a cause of disease.
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O definicjach zdrowia i choroby

63%
EN
Health and disease play an important role in the history of medicine. Both terms are also crucial for the organization and functioning of medicine and a society at large. Nevertheless, although attempts to define health and disease have been made by physicians, philosophers, sociologists and psychologists, they have failed to succeed. Thus, the question arises whether semantic pluralism makes it possible to answer the question what health and disease are. The article aims at analysing the existing typologies of definitions of both the issues and supporting the argument that while many claim that the ongoing discussion on the meaning of both terms is purely academic, the concepts of health and disease are crucial for clinical practice and the organization of medicine and a society as a whole.
PL
Zdrowie i choroba odgrywają ważną rolę w historii medycyny. Oba pojęcia są również istotne dla organizacji i funkcjonowania medycyny i społeczeństwa. Niemniej jednak, choć próby definiowania obu pojęć podejmowali lekarze, filozofowie, socjologowie czy psychologowie to do dziś nie zakończyły się one sukcesem. Pytaniem fundamentalnym jest więc kwestia, czy panujący pluralizm znaczeniowy czyni możliwym odpowiedź na pytanie o to, czym zdrowie i choroba są. Celem tekstu jest analiza istniejących typologii definicji zdrowia i choroby oraz dostarczenie argumentacji na rzecz tezy, że wbrew twierdzeniom, iż dyskusja nad oboma pojęciami ma charakter czysto akademicki, to koncepcje zdrowia i choroby są kluczowe dla praktyki klinicznej, organizacji medycyny i społeczeństwa.
OphthaTherapy
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2022
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vol. 9
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issue 3
195-199
PL
Dekspantenol – prekursor witaminy B5 – jest związkiem pochodzenia naturalnego, który ma znany od dawna dobroczynny wpływ na nawilżenie skóry i błon śluzowych oraz na gojenie się nabłonków. W leczeniu wykorzystuje się również jego aktywność przeciwzapalną. Wpływ dekspantenolu na tkanki powierzchowne był obserwowany w licznych badaniach in vitro i in vivo, jednak dokładny mechanizm działania nie został do tej pory poznany. W okulistyce dekspantenol jest znanym i szeroko stosowanym lekiem u pacjentów z ostrymi i przewlekłymi chorobami powierzchni oka oraz następstwami urazów rogówki.
EN
Dexpanthenol - a precursor to vitamin B5 - is a compound of natural origin that has a long-known beneficial effect on skin and mucous membrane hydration and epithelial healing. Its anti-inflammatory activity is also used in treatment. Its effects on superficial tissues have been observed in numerous in vitro and in vivo studies, but the exact mechanism of action has not yet been understood. In ophthalmology, dexpanthenol is a well-known and widely used drug in patients with acute and chronic diseases of the ocular surface, as well as for treating the sequelae of corneal injuries.
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