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The Relationship between Glycohemoglobin Levels and Insulin Sensitivity in Diabetic Adult Patients

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Ezeorah F. C., Edoziuno M. O.
World News of Natural Sciences
|
2026
|
vol. 64
222-231
EN
The increasing prevalence of prediabetes and type 2 diabetes poses a significant threat to global health, emphasizing the need for early identification and intervention. The aim of this study is to investigate the relationship between glycohemoglobin levels and insulin sensitivity in prediabetic and diabetic adult patients. The study utilized data extracted from the National Health and Nutrition Examination Survey (NHANES) conducted by the Centers for Disease Control and Prevention (CDC) in the USA. Data cleaning and manipulation were performed to ensure accuracy and reliability, and insulin sensitivity was calculated using the Quantitative Insulin Sensitivity Check Index (QUICKI) method. The results revealed a statistically significant negative relationship between glycohemoglobin levels and insulin sensitivity in both prediabetic (p = 0.000, r = -0.0074) and diabetic adults (p = 0.046, r = -0.0019), indicating that as glycohemoglobin levels increase, insulin sensitivity decreases. These findings highlight the importance of maintaining optimal glycohemoglobin levels, particularly in the prediabetic stage, to prevent or delay the onset of insulin resistance and type 2 diabetes. The study's outcomes contribute to the understanding of the complex relationship between glycohemoglobin and insulin sensitivity, providing valuable insights for the development of targeted interventions and treatment strategies for individuals with prediabetes and diabetes. The study's results emphasize the need for early detection and monitoring of glycohemoglobin levels, as well as the implementation of lifestyle modifications and therapeutic interventions to improve insulin sensitivity and prevent the progression to type 2 diabetes. This study provides important implications for the prevention and management of type 2 diabetes, and highlights the need for continued research into the relationship between glycohemoglobin and insulin sensitivity.
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