Search results

1

Diabetes association of polyps and colon cancer

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Miłek T., Forysiński K., Myrcha P., Ciostek P.

Polish Journal of Surgery

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2019

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vol. 91(4)

9-12

EN

Aim: The aim of the study was to retrospectively assess the relationship between the occurrence of polyps and colon cancer in patients with type 2 diabetes. Methods: In 2014–2015, 976 colonoscopies were performed in patients. We compared the number of polyps with high-grade dysplasia and colorectal cancers in patients with and without diabetes. In addition, in the diabetic group we documented the relationship between HbA1C and the occurrence of polyps with high-grade dysplasia, and colon cancer. The data were statistically analyzed. Results: 1. Patients with diabetes show a higher incidence of polyps with high-grade dysplasia/carcinoma – 32/91 (35.16%) in comparison to patients without diabetes – 136/885 (15.37%), P < 0.001; 2. Patients with diabetes show a higher incience of polyps with cancer – 9/91 (9.89%) as compared to patients without diabetes – 18/885 (2.03%), P < 0.001. 3) Colorectal cancer occurred significantly more often in uncontrolled diabetes (P = 0.022). Conclusion: The conducted study shows a significant association between type 2 diabetes and the incidence of colorectal adenomas. These findings may lead to a conclusion that diabetic patients are at a higher risk of developing colorectal cancer, thus are in higher need for controlled colonoscopy. Therefore, it may be worth considering a scheme for screening patients in the above-mentioned group with colonoscopy.

2

Factors Associated with Physical Activity in People with Diabetes

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Sieńko-Awieraniów E., Stępień-Słodkowska M., Latkowska A., Głowacka E.

Central European Journal of Sport Sciences and Medicine

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2015

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vol. 12

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issue 4

73-81

EN

Background: Diabetes mellitus is a chronic disease related to the occurrence of numerous metabolic disorders. Their common feature is hyperglycaemia, caused by insufficient insulin secretion or its malfunction. The World Health Organization states that 346 million people worldwide have diabetes. The studies in adults with type 2 diabetes clearly demonstrate that the change of lifestyle behaviours effectively improves glycemic control. The modifications of lifestyle habits, such as regular physical activity and healthier dietary habits prove to be beneficial for patients. The aim of this study was to determine the factors affecting the level of physical activity in people with diabetes mellitus. Methods: Research material consisted of the data gathered from a diagnostic survey, which was conducted in a form of a questionnaire. The study included 60 people with type 1 or type 2 diabetes. Results: Unfortunately, the results show that not all of them were active enough, which is so crucial for stabilizing the disease. Conclusions: The diagnosis of diabetes in the respondents resulted in more time being spent by them on physical activity, which resulted in the improvement of diabetes control and the normalization of body weight according to BMI, thus increasing the effectiveness of diabetes treatment and reducing complications. The frequency of the physical activity undertaken by the respondents prior to the disease was not related to gender, however, after the diagnosis, it was dependent on gender

3

Analysis of diabetes-related complications and the cost of diabetes in Poland. The methodology and the research sample used in Economedica DM-PL Survey

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Bogusławski S., Wojciechowska A., Smaga A., Strojek K., Wróbel K., Wojtyniak B., Juszczyk G., Czech M., Zdrojewski T.

European Journal of Translational and Clinical Medicine

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2023

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vol. 6

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issue 1

31-40

EN

Background: Knowledge about diabetes mellitus (DM)-related complications, the direct and indirect costs incur red by patients with DM is still insufficient in Poland. Economedica DM-PL (Economedica) survey was a cross-sectional observational study that aimed to assess these issues. Material and methods: The survey was carried out in 2016 on a representative sample of 2032 diabetic patients recruited by 195 general practioners (GP) and 48 diabetologists (D) randomly selected from the national registry of physicians. Each GP and D recruited 8 to 10 patients with DM according to the specified protocol. The study included 1938 medical questionnaires (comple ted by the GPs and Ds), 1938 questionnaires about costs (completed by the patients) and 1532 treatment adherence questionnaires. Results: The Economedica survey provided new insights into DM epidemiological and cost data. 70% of patients with type-1 DM were diagnosed with the disease before the age of 40. For 76% patients with type-2 DM, it was diagnosed aeftr the age of 50. The average monthly out-of-pocket medical costs for DM patients in 2016 reached 66.2 EUR, while their non-medical costs were 36.8 EUR. Conclusions: The methodology applied in our study proved useful for providing new dimensions of DM epidemiological and cost data in Poland.

4

Coexistence of type 1 diabetes mellitus and spinal muscular atrophy in an 8-year-old girl: a case report

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Borkowska A., Jankowska A., Szlagatys-Sidorkiewicz A., Sztangierska B., Liberek A., Plata-Nazar K., Kamińska B.

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issue 1

167-168

EN

The spinal muscular atrophy is a rare autosomal recessive genetic disease characterized by the progressive loss of muscular strength. In its natural course the disease leads to death. Diabetes mellitus type 1 is an autoimmune metabolic disorder characterized by the disturbed insulin synthesis. This is a case report of an 8-year-old girl suffering from Werdnig Hoffman disease in whom DM1 was diagnosed. The unspecific clinical manifestation and diagnostic difficulties are presented in this paper. To the authors' knowledge, this is the first publication concerning the co-existence of these two medical conditions.

5

White blood cells count and its populations in patients with acute coronary syndromes and co-morbidities

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Vakaliuk I., Alghzawi I.

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EN

INTRODUCTION: Acute coronary syndromes (ACS) and sudden death cause most ischemic heart disease (IHD)- related deaths, which represent 1.8 million deaths per year, with similar numbers of men and women dying from coronary artery disease (CAD). It’s known that inflammation plays crucial role in atherosclerotic plaque formation and its destabilization. The purpose of this study is to evaluate of white blood cells count in its subpopulation in patients with ACS and modifiable cardiovascular risk factors – arterial hypertension and 2 type Diabetes Mellitus (DM). MATERIAL AND METHODS: In this observational cohort trial we observed of 184 patients with ACS. All patients were randomized into four groups: 1st group - 42 patients with ACS without arterial hypertension (AH) or DM; 2nd group – 56 patients with ACS and previous AH; 3rd group – 42 patients with ACS and 2 type DM; and 4th group – 44 patients with ACS and AH and DM. We studied of leukocytes count and their subpopulations in blood. RESULTS: The mean white blood cells count was significant higher in patients with ASC, compared with control group: 8.23 [6.50; 9.40] vs 5.49 [5.20; 5.70] (p<0.001). Similarly, ACS caused increase of leukocytes subpopulation count in blood. The significant higher count of white blood cells was observed in patients with ACS and co-morbidities: 2 type DM and its association with AH. In patients with ACS and previous AH we observed significant lower neutrophils count (p<0.05), but increased quantity of lymphocytes, compared with patients with ACS without co-morbidities (p<0.001). DM and its association with AH was characterized of neutrophils, lymphocytes and monocytes counts growth. CONCLUSIONS:ACS is characterized of raised white blood cells count and its population, especially in cases of association with 2 type Diabetes Mellitus.

6

The importance of obesity and carbohydrate metabolism disorders on the course of gastroesophageal reflux disease – a pilot study

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Pardak P., Filip R., Krzaczek M.

European Journal of Translational and Clinical Medicine

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2022

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vol. 5

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issue 1

17-26

EN

BackgroundCarbohydrate metabolism disorders, obesity and a severe course of gastroesophageal reflux correlate with more frequent development of esophageal complications. The aim of this study was to assess the influence of obesity and carbohydrate disorders on the characteristics of gastroesophageal reflux disease (GERD).Material and methodsThe study included 58 patients with excess weight. Anthropometric parameters (including the body mass index, BMI), data regarding GERD (severity of symptoms, gastroscopy and esophageal pH monitoring results) were included in the study. Correlations between obesity and GERD parameters were analyzed. Subjects were divided into a diabetic and a control group and the severity of GERD was compared.ResultsGERD was diagnosed in 40 patients and occurred more frequently in the obese group (73%) than in the overweight group (57%). Increased GERD severity was associated with increased BMI only for postprandial parameters. GERD was diagnosed in most of the group with carbohydrate disorders (78% vs 63% in the non-diabetic group). No differences in the severity of GERD were observed between groups depending on carbohydrate disorders.ConclusionsIn our study, GERD was common in obesity and in diabetic disorders. Increased severity of postprandial reflux was associated with an increased BMI. Diabetic disorders were not associated with more severe GERD.

7

Activity of superoxide dismutase obtained from senile cataract lens - effect of diabetes mellitus

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Panz T., Wójcik R., Krukar-Baster K.

Acta Biochimica Polonica

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2008

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vol. 55

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issue 4

821-823

EN

The activity of Cu,Zn superoxide dismutase in the fluid obtained from eye lens capsules after cataract surgery was investigated in samples obtained from patients with senile cataract and with senile cataract combined with diabetes mellitus. Two parameters were measured and compared: the frequency of occurrence of detected superoxide dismutase activity and the relative activity of the enzyme in samples derived from senile cataract patients versus those from the patiens affected additionally by diabetes mellitus. It was confirmed that the decrease of superoxide dismutase activity during cataract was additionally promoted by diabetes mellitus.

8

High resolution ultrasonography of the tibial nerve in diabetic peripheral neuropathy

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Singh K., Gupta K., Kaur S.

Journal of Ultrasonography

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2017

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vol. 17

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issue 71

246-252

EN

Aim of the study: High-resolution ultrasonography of the tibial nerve is a fast and non invasive tool for diagnosis of diabetic peripheral neuropathy. Our study was aimed at finding out the correlation of the cross sectional area and maximum thickness of nerve fascicles of the tibial nerve with the presence and severity of diabetic peripheral neuropathy. Material and methods: 75 patients with type 2 diabetes mellitus clinically diagnosed with diabetic peripheral neuropathy were analysed, and the severity of neuropathy was determined using the Toronto Clinical Neuropathy Score. 58 diabetic patients with no clinical suspicion of diabetic peripheral neuropathy and 75 healthy non-diabetic subjects were taken as controls. The cross sectional area and maximum thickness of nerve fascicles of the tibial nerves were calculated 3 cm cranial to the medial malleolus in both lower limbs. Results: The mean cross sectional area (22.63 +/– 2.66 mm2 ) and maximum thickness of nerve fascicles (0.70 mm) of the tibial nerves in patients with diabetic peripheral neuropathy compared with both control groups was significantly larger, and statistically significant correlation was found with the Toronto Clinical Neuropathy Score (p < 0.001). The diabetic patients with no signs of peripheral neuropathy had a larger mean cross sectional area (14.40 +/– 1.72 mm2 ) and maximum thickness of nerve fascicles of the tibial nerve (0.40 mm) than healthy non-diabetic subjects (12.42 +/– 1.01 mm2 and 0.30 mm respectively). Conclusion: The cross sectional area and maximum thickness of nerve fascicles of the tibial nerve is larger in diabetic patients with or without peripheral neuropathy than in healthy control subjects, and ultrasonography can be used as a good screening tool in these patients.

PL

Cel pracy: Ultrasonografia wysokiej rozdzielczości nerwu piszczelowego jest szybką i nieinwazyjną metodą możliwą do wykorzystania w rozpoznaniu cukrzycowej neuropatii obwodowej. Celem naszej pracy było ustalenie, czy istnieje zależność pomiędzy polem przekroju poprzecznego oraz maksymalną grubością pęczków nerwu piszczelowego a występowaniem i zaawansowaniem cukrzycowej neuropatii obwodowej. Materiał i metoda: Badaniu poddano 75 pacjentów cierpiących na cukrzycę typu 2 z klinicznym rozpoznaniem cukrzycowej neuropatii obwodowej. Stopień zaawansowania neuropatii oceniany był za pomocą Klinicznej skali neuropatii Toronto (Toronto Clinical Neuropathy Score). Grupę kontrolną w badaniu stanowiło 58 pacjentów z cukrzycą bez objawów klinicznych cukrzycowej neuropatii obwodowej oraz 75 zdrowych osób. Pole przekroju poprzecznego oraz maksymalna grubość pęczków nerwu piszczelowego wyliczane były na wysokości 3 cm powyżej kostki przyśrodkowej w obu kończynach dolnych. Wyniki: Średnie pole przekroju poprzecznego (2,63 +/− 2,66 mm2) oraz maksymalna grubość pęczków nerwu piszczelowego (0,70 mm) u pacjentów z cukrzycową neuropatią obwodową były istotnie statystycznie większe niż u osób z obu grup kontrolnych. Stwierdzono także występowanie istotnej statystycznie zależności pomiędzy wielkością tych parametrów a stopniem zaawansowania cukrzycowej neuropatii obwodowej według Klinicznej skali neuropatii Toronto (p < 0,001). U pacjentów chorujących na cukrzycę bez występowania objawów klinicznych cukrzycowej neuropatii obwodowej pole przekroju poprzecznego (14,40 +/− 1,72 mm2) oraz maksymalna grubość pęczków nerwu piszczelowego (0,40 mm) były większe niż u zdrowych uczestników badania (odpowiednio 12,42 +/− 1,01 mm2 i 0,30 mm). Wnioski: Przekrój oraz maksymalna grubość pęczków nerwu piszczelowego są większe niż u osób zdrowych zarówno u pacjentów z cukrzycą cierpiących na cukrzycową neuropatię obwodową, jak i bez klinicznych objawów neuropatii. Ultrasonografia może być z powodzeniem wykorzystywana u chorych z cukrzycą jako badanie przesiewowe pod kątem występowania cukrzycowej neuropatii obwodowej. Artykuł w wersji polskojęzycznej jest dostępny na stronie http://jultrason.pl/index.php/wydawnictwa/volume-17-no-71

9

The feasibility of using high-resolution ultrasonography to assess ulnar nerve in patients with diabetes mellitus

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Chen J., Wang C.-L., Wu S., He S., Ren J.

Journal of Ultrasonography

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2017

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vol. 17

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issue 70

160-166

EN

Objective: The aim of this study was to investigate the usefulness of high-resolution ultrasonography for the diagnosis of polyneuropathy in diabetes mellitus patients by the examination of the ulnar nerves. Method: We recruited 100 healthy age-matched volunteers (50 women and 50 men) with 200 arms without diabetes or cubital tunnel syndrome as the control group. We assessed the upper limbs of 100 diabetes mellitus patients (45 women and 55 men), 40 of whom had electrophysiologically confirmed diabetic peripheral neuropathy and 60 had no diabetic peripheral neuropathy in the upper limbs. Age, sex, height and weight were recorded and the cross-sectional area of the ulnar nerve was measured at every predetermined site. Results: The cross-sectional area of the ulnar nerve was measured at six sites (mid-humerus, inlet of the cubital tunnel, outlet of the cubital tunnel, upon the medial epicondyle, 6 cm upon the wrist crease and Guyon tunnel). The ulnar nerve in two measuring sites (mid-humerus, upon the medial epicondyle) in the control group showed a statistical difference between men and women (p < 0.05). There was no statistical difference in the cross-sectional area in the control group when dominant and non-dominant arms were compared. The cross-sectional area was larger in the diabetic peripheral neuropathy group in three sites (inlet of the cubital tunnel, outlet of the cubital tunnel, Guyon tunnel) compared with those in the control group. Conclusion: High-resolution ultrasonography may be helpful in the early diagnosis of peripheral neuropathy in diabetic patients.

PL

Cel: Celem badania było określenie przydatności ultrasonografii wysokiej rozdzielczości w diagnostyce polineuropatii u pacjentów z cukrzycą poprzez badanie nerwu łokciowego. Metoda: Przebadano kończyny górne 100 pacjentów z cukrzycą (45 kobiet i 55 mężczyzn), z których 40 cierpiało na elektrofizjologicznie potwierdzoną obwodową neuropatię cukrzycową, a u 60 nie rozpoznano obwodowej neuropatii cukrzycowej w kończynach górnych. Jako grupa kontrolna w badaniu udział wzięło 100 zdrowych wolontariuszy w podobnym wieku (50 kobiet i 50 mężczyzn), niecierpiących na cukrzycę ani zespół kanału łokciowego (łącznie 200 rąk). Określono wiek, płeć, wzrost i wagę oraz zmierzono pole przekroju poprzecznego nerwu łokciowego w każdym ustalonym miejscu. Wyniki: Pole przekroju poprzecznego nerwu łokciowego zmierzono w sześciu miejscach (środek kości ramiennej, wejście do kanału łokciowego, wyjście z kanału łokciowego, nad nadkłykciem przyśrodkowym, 6 cm ponad nadgarstkiem i kanał Guyona). W grupie kontrolnej wykazano statystycznie istotną różnicę w nerwie łokciowym w dwóch miejscach pomiaru (środek kości ramiennej, nad nadkłykciem przyśrodkowym) pomiędzy mężczyznami a kobietami (p < 0,05). Nie wykazano różnicy statystycznej w polu przekroju poprzecznego w grupie kontrolnej podczas porównywania ręki dominującej i niedominującej. Pole przekroju poprzecznego było większe w grupie z obwodową neuropatią cukrzycową w trzech miejscach (wejście do kanału łokciowego, wyjście z kanału łokciowego, kanał Guyona) w porównaniu z grupą kontrolną. Wniosek: Ultrasonografia wysokiej rozdzielczości może okazać się pomocna we wczesnej diagnostyce neuropatii obwodowej u pacjentów z cukrzycą. Artykuł w wersji polskojęzycznej jest dostępny na stronie http://jultrason.pl/index.php/wydawnictwa/volume-17-no-70

10

Influence of Carbohydrate Metabolism Disturbances on Early Postoperative Complications in Patients after Planned Coronary Artery By-pass Graft Surgery

88%

Greberski K., Bugajski P., Kalawski R., Guzik P., Wysocki H.

Polish Journal of Surgery

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2007

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vol. 79

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issue 7

496-502

EN

Improper glucose metabolism unfavorably influences the peri- and postoperative course, considering patients subjected to coronary artery bypass graft surgery. In case of such patients, one can observe an increased amount of perioperative complications.The aim the study was to determine the correlation between carbohydrate metabolism disturbances and mortality, as well as other postoperative complications in patients subjected to coronary artery bypass graft surgery.Material and methods. The study group comprised 117 patients under 80 years of age qualified for coronary artery bypass graft surgery using extracorporeal circulation and Off-Pump Coronary Artery Bypass (OPCAB). Patient observations were undertaken during hospitalization and six weeks after CABG. The examination was of prospective and observational character. The following end-points were considered:1. Cardiological complications:- death connected with cardiac diseases,- cardiogenic shock (low-output syndrome requiring the use of IABP),- pulmonary edema,- myocardial infarction.2. Other complications:- cerebral stroke,- renal insufficiency,- impaired postoperative wound healing following sternotomy or after saphenous veinConsidering statistical analysis, the following patient groups were distinguished: normal glucose metabolism (NGM), impaired glucose metabolism (IGM) or impaired fasting glucose (IFG), previously diagnosed or new diagnosis of diabetes mellitus (DM). The IGT and IFG groups were described as AGM-noDM (abnormal glucose metabolism- no diabetes mellitus).Results. The total number of postoperative complications, considering particular patient groups was as follows: in the NGM group, postoperative complications were noted in 3 (8.8%) patients (p<0.001) vs 9 (23.7%) in the AGM-noDM group (p<0.001) vs 21 (46.7%) in the DM group (p<0.001).The occurrence of particular complications was as follows: cardiogenic shock requiring intra-aortic balloon contrapulsation in 1 (2.9%) patient with NGM vs 1 (2.6%) with AGM-noDM vs 2 (4.4%) with DM. Acute renal insufficiency was observed in 1 (2.9%) patient with NGM vs 3 (7.9%) with AGM-noDM vs 6 (13.3%) with DM. Coronary by-pass graft impatency was noted in 0 patients with NGM vs 0 with AGM-noDM vs 3 (6.7%) patients with DM (p=0.085). Reoperation due to postoperative bleeding was required in 2 (5.9%) patients with NGM vs 4 (10.5%) with AGM-noDM vs 4 (8.9%) with DM. Postoperative cerebral stroke was observed in 0 patients with NGM vs 1 (2.6%) with AGM-noDM vs 2 (4.4%) with DM. Impaired sternotomy wound healing concerned 0 patients with NGM vs 2 (5.9%) with AGM-noDM vs 1 (2.2%) with DM. Impaired saphenous vein wound healing was observed in 0 patients with NGM vs 2 (5.3%) with AGM-noDM vs 23 (51.1%) with DM (p<0.001).Pulmonary edema was observed in 0 patients with NGM vs 1 (2.6%) with AGM-noDM vs 0 with DM. Death did not ocuured in cases of patients with NGM vs 1 (2.6%) with AGM-noDM vs 3 (6.7%) with DM.Conclusions. Postoperative complications occurred more frequently in patients with carbohydrate metabolism disturbances, especially diabetes mellitus, subjected to planned coronary artery bypass graft surgery.

11

A proteomics approach to identify the differential protein level in cardiac muscle of diabetic rat

88%

Karthik D., Vijayakumar R., Pazhanichamy K., Ravikumar S.

Acta Biochimica Polonica

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2014

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vol. 61

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issue 2

285-293

EN

Background: Cardiovascular proteomics investigation reveals the characterization and elucidation of the novel therapeutic targets and strategies to prevent the development of heart failure associated diabetic complication by using 2DE and MS. Methods: The experimental animals were made diabetic with a single intraperitoneal injection of alloxan (150 mg/kg of bw). Albino rats were randomly divided into four individual groups: Group-I control (n=6), group-II alloxan-induced diabetic rats, untreated (n=6), group-III (n=6) and group-IV (n=6) alloxan-induced diabetic rats were treated with aqueous and ethanolic extracts of Cynodon dactylon for 15 days, respectively. Animals were euthanized to collect the heart tissues and blood samples. 2DE sample preparation, gel running and staining (n=6: each groups) were performed at the same time to avoid variation. The result of six gel images from each group were analyzed and evaluated as one match set with 2D software (P<0.05). Results: The above experiment revealed two up-regulated proteins in group-II i.e. NTF4 and ETFB. Conclusions: NTF4 is a neuro-protective agent for neuro-degenerative diseases. It will prevent diabetic secondary complications, such as diabetic polyneuropathy and cardiomyopathy. ETFB is active in the mitochondria, the energy-producing centres in cells. It is clear from the experiment that because of up-regulation of ETFB more energy is availabile and the electron transfer for heart during diabetes is possible, what leads to reduce the oxidative stress and free-radical formation. The up-regulated proteins reduced CVD that occurred just before overt hyperglycaemia due to administration of C. dactylon. This approach established the preliminary reference map for decoding cellular mechanisms linked between pathogenesis CVD and diabetes.

12

The association between ALR2 -106C > T gene polymorphisms and diabetic retinopathy susceptibility in diabetes mellitus patient: a systematic review and meta-analysis

88%

Putri I. S., Rezkita B. E., Irving S., Azmiardi A.

OphthaTherapy

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2023

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vol. 10

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issue 1

12-21

EN

Aldose reductase gene polymorphisms has been indicated to be associated with diabetic retinopathy (DR). The research data were from PubMed and EMBASE. We identified -106C > T single nucleotide polymorphism (SNP). Pool odds ratio (OR) with 95% CI were calculated. Nine studies were included. ALR2 106C > T gene polymorphisms was associated with the increased risk of DR in T1DM (C vs. T, OR = 2.07, p = 0.001; CC vs. CT + TT, OR = 2.56, p = 0.005). T allele and TT genotype were associated with decreased risk of DR in T1DM (OR = 0.48, p = 0.0001 and OR = 0.12, p = 0.0005). In conclusion, C allele and CC genotype may be a risk factor, while T allele and TT genotype may serve as protective factor for DR in T1DM patient.

13

Eating habits of patients with type 2 diabetes mellitus with regard to body mass index

88%

Janion K., Szczepańska E.

Annales Academiae Medicae Silesiensis

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2017

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vol. 71

363-370

EN

INTRODUCTION: Recent years have seen a significant increase in the incidence of diabetes mellitus, type 2 diabetes in particular, which closely correlates with the growing problem of overweight and obesity. The aim of the study was to compare eating habits among type 2 diabetic patients with varying body weight as well as to verify whether there was a relationship between dietary habits and the body mass index in these patients. MATERIAL AND METHODS: The study was conducted in diabetology outpatient clinics. A total of 353 diabetic patients participated in the study. The study consisted of two parts, i.e. authors' questionnaire and anthropometric measurements. RESULTS: The recommended number of 4–5 meals a day was declared by 48.6% of subjects with normal body weight, 50.3% of overweight and 48.4% of obese patients. Daily consumption of breakfast was confirmed by 77.1%, 73.9% and 77.8% of respondents, respectively. Daily consumption of whole-grain bread and coarse grits was mostly declared by subjects with normal body weight (62.8%), followed by overweight and obese patients (22.9% and 23%, respectively). Daily consumption of milk and fermented dairy beverages was reported by 24.3% and 15.7% of subjects with normal body weight, 22.3% and 14.7% of overweight patients as well as by 16.7% and 12% of obese patients, respectively. CONCLUSIONS: Eating habits among patients with type 2 diabetes are varied, with healthy eating habits dominating in subjects with normal body weight. A relationship was found between the patients’ BMI values and some of the eating habits as well as consumption rates of various food products.

PL

WSTĘP: W ostatnich latach odnotowuje się znaczący wzrost zachorowalności na cukrzycę, zwłaszcza typu 2, co ściśle koreluje z narastającym problemem nadwagi i otyłości. Celem pracy było porównanie nawyków żywieniowych pacjentów z cukrzycą typu 2 o różnej masie ciała oraz odpowiedź na pytanie, czy występują zależności pomiędzy nawykami a wskaźnikiem masy ciała (BMI) badanych osób. MATERIAŁ I METODY: Badanie zostało przeprowadzone w poradniach diabetologicznych wśród 353 pacjentów z cukrzycą. Składało się z dwóch części – przeprowadzenia ankiety z wykorzystaniem autorskiego kwestionariusza oraz wykonania pomiarów antropometrycznych. WYNIKI: Spożywanie zalecanej liczby 4–5 posiłków w ciągu dnia zadeklarowało 48,6% osób z prawidłową masą ciała, 50,3% z nadwagą oraz 48,4% z otyłością. Codzienne spożywanie I śniadania potwierdziło odpowiednio 77,1%, 73,9% oraz 77,8% z nich. Codzienną konsumpcję pełnoziarnistego pieczywa i gruboziarnistych kasz najczęściej deklarowały osoby z prawidłową masą ciała (62,8%), rzadziej osoby z nadwagą i otyłością, odpowiednio 22,9% i 23% wskazań. Spożycie mleka i mlecznych napojów fermentowanych każdego dnia deklarowało odpowiednio 24,3% i 15,7% osób z prawidłową masą ciała, 22,3% i 14,7% z nadwagą oraz 16,7% i 12% z otyłością. WNIOSKI: Nawyki żywieniowe badanych pacjentów z cukrzycą typu 2 są zróżnicowane, przy czym największą liczbę prawidłowych nawyków żywieniowych zaobserwowano u osób z prawidłową masą ciała. Stwierdzono, iż występuje zależność pomiędzy BMI badanych pacjentów a niektórymi nawykami żywieniowymi i częstością spożycia poszczególnych produktów spożywczych.

14

Changes in the clinical characteristics of women with gestational diabetes mellitus — a retrospective decade-long single center analysis

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Wilk M., Cyganek K., Matejko B., Krzyżowska S., Lasoń I., Katra B., Zięba-Parkitny J., Witek P., Małecki M. T., Wilk M., Cyganek K., Matejko B., Krzyżowska S., Lasoń I., Katra B., Zięba-Parkitny J., Witek P., Małecki M. T.

Folia Medica Cracoviensia

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2020

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vol. 60

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issue 4

15

Purinergic signaling in the pancreas and the therapeutic potential of ecto-nucleotidases in diabetes

75%

Cieślak M., Roszek K.

Acta Biochimica Polonica

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2014

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vol. 61

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issue 4

655-662

EN

It is widely accepted that purinergic signaling is involved in the regulation of functions of all known tissues and organs. Extracellular purines activate two classes of receptors, P1-adenosine receptors and P2-nucleotide receptors, in a concentration-dependent manner. Ecto-enzymes metabolizing nucleotides outside the cell are involved in the termination of the nucleotide signaling pathway through the release of ligands from their receptors. The pancreas is a central organ in nutrient and energy homeostasis with endocrine, exocrine and immunoreactive functions. The disturbances in cellular metabolism in diabetes mellitus lead also to changes in concentrations of intra- and extracellular nucleotides. Purinergic receptors P1 and P2 are present on the pancreatic islet cells as well as on hepatocytes, adipocytes, pancreatic blood vessels and nerves. The ATP-dependent P2X receptor activation on pancreatic β-cells results in a positive autocrine signal and subsequent insulin secretion. Ecto-NTPDases play the key role in regulation of extracellular ATP concentration. These enzymes, in cooperation with 5'-nucleotidase can significantly increase ecto-adenosine concentration. It has been demonstrated that adenosine, through activation of P1 receptors present on adipocytes and pancreatic islets cells, inhibits the release of insulin. Even though we know for 50 years about the regulatory role of nucleotides in the secretion of insulin, an integrated understanding of the involvement of purinergic signaling in pancreas function is still required. This comprehensive review presents our current knowledge about purinergic signaling in physiology and pathology of the pancreas as well as its potential therapeutic relevance in diabetes.

16

The Effect of a Long-Term, Community-Based Exercise Program on Bone Mineral Density in Postmenopausal Women with Pre-Diabetes and Type 2 Diabetes

75%

Bello M., Sousa M. C., Neto G., Oliveira L., Guerras I., Mendes R., Sousa N.

Journal of Human Kinetics

|

2014

|

vol. 43

|

issue 1

43-48

EN

The aim of this study was to evaluate the impact of a community-based exercise program on bone mineral density and body composition in postmenopausal women with pre-diabetes and type 2 diabetes. Twenty postmenopausal women (aged 61.3 ± 6.0 years) with pre-diabetes and type 2 diabetes were randomly assigned to a community-based exercise program group (n=10) or a control group (n=10). The community-based exercise program was multicomponent, three days per week for 32 weeks, and included walking, resistance and aquatic exercises. Body composition and bone mineral density were measured pre and post-training by dual X-ray absorptiometry. In the exercise group significant increases were found in the ward’s triangle bone mineral density (+7.8%, p=0.043), and in fat-free mass (+2.4%, p=0.018). The findings suggest that regular multicomponent training is effective in preventing osteoporosis and sarcopenia among postmenopausal women with pre-diabetes and type 2 diabetes.

17

POZIOM WIEDZY I OCZEKIWANIA EDUKACYJNE CHOREGO NA CUKRZYCĘ TYPU 2 W ŚRODOWISKU WIEJSKIM

75%

Tokarska M.

Long-Term Care Nursing

|

2019

|

vol. 3

|

issue 4

EN

Introduction In the treatment of type 2 diabetes, patients‚ knowledge and behavioral intervention, as well as a comprehensive change in the patients’ approach to their own health, are of great importance. Aim The aim of the work is to present demographic characteristics and lifestyle of persons suffering from type 2 diabetes. Material and methods The study was conducted among 35 patients diagnosed with type 2 diabetes under the care of NZOZ Eskulap in Wiśniewo POZ. The diagnostic survey method was used with the use of a self-made questionnaire. Results The largest group were those who had diabetes up to 5 years old - 14 people (40.05%). Just over half of the respondents used insulin - 18 people (51.4%). Five people (14.3%) admitted to smoking tobacco, 19 people to drink alcohol or other alcoholic beverages (54.3%). Test subjects using insulin did not perform recreational exercises ever - 18 people (100.0%) Conclusions The anti-health lifestyle of respondents requires the integration of interdisciplinary educational activities in this area.

PL

Wstęp W leczeniu cukrzycy typu 2 ogromne znaczenie ma wiedza chorych i interwencja behawioralna oraz kompleksowa zmiana podejścia chorych do własnego zdrowia. Cel Celem pracy jest przedstawienie cech demograficznych i stylu życia osób chorujących na cukrzycę typu 2. Materiał i metody Badanie przeprowadzono wśród 35 pacjentów z rozpoznaną cukrzycą typu 2 pozostających pod opieką NZOZ Eskulap w Wiśniewie POZ. Zastosowano metodę sondażu diagnostycznego z wykorzystaniem kwestionariusza konstrukcji własnej. Wyniki Najliczniejszą grupę stanowili badani, którzy chorowali na cukrzycę do 5 lat – 14 osób (40,05%). Niewiele ponad połowa badanych stosowała insulinę – 18 osób (51,4%). Do palenia tytoniu przyznało się 5 osób (14,3%), do spożywania alkoholu lub innych napojów alkoholowych – 19 osób (54,3%). Badani stosujący insulinę nie wykonywali ćwiczeń rekreacyjnych nigdy – 18 osób (100,0%) Wnioski Antyzdrowotny styl życia respondentów wymaga integracji interdyscyplinarnych działań edukacyjnych w tym zakresie.

18

POZIOM WIEDZY I OCZEKIWANIA EDUKACYJNE CHOREGO NA CUKRZYCĘ TYPU 2 W ŚRODOWISKU WIEJSKIM

75%

Tokarska M.

Long-Term Care Nursing

|

2019

|

vol. 3

|

issue 1

EN

Introduction In the treatment of type 2 diabetes, patients‚ knowledge and behavioral intervention, as well as a comprehensive change in the patients’ approach to their own health, are of great importance. Aim The aim of the work is to present demographic characteristics and lifestyle of persons suffering from type 2 diabetes. Material and methods The study was conducted among 35 patients diagnosed with type 2 diabetes under the care of NZOZ Eskulap in Wiśniewo POZ. The diagnostic survey method was used with the use of a self-made questionnaire. Results The largest group were those who had diabetes up to 5 years old - 14 people (40.05%). Just over half of the respondents used insulin - 18 people (51.4%). Five people (14.3%) admitted to smoking tobacco, 19 people to drink alcohol or other alcoholic beverages (54.3%). Test subjects using insulin did not perform recreational exercises ever - 18 people (100.0%) Conclusions The anti-health lifestyle of respondents requires the integration of interdisciplinary educational activities in this area.

PL

Wstęp W leczeniu cukrzycy typu 2 ogromne znaczenie ma wiedza chorych i interwencja behawioralna oraz kompleksowa zmiana podejścia chorych do własnego zdrowia. Cel Celem pracy jest przedstawienie cech demograficznych i stylu życia osób chorujących na cukrzycę typu 2. Materiał i metody Badanie przeprowadzono wśród 35 pacjentów z rozpoznaną cukrzycą typu 2 pozostających pod opieką NZOZ Eskulap w Wiśniewie POZ. Zastosowano metodę sondażu diagnostycznego z wykorzystaniem kwestionariusza konstrukcji własnej. Wyniki Najliczniejszą grupę stanowili badani, którzy chorowali na cukrzycę do 5 lat – 14 osób (40,05%). Niewiele ponad połowa badanych stosowała insulinę – 18 osób (51,4%). Do palenia tytoniu przyznało się 5 osób (14,3%), do spożywania alkoholu lub innych napojów alkoholowych – 19 osób (54,3%). Badani stosujący insulinę nie wykonywali ćwiczeń rekreacyjnych nigdy – 18 osób (100,0%) Wnioski Antyzdrowotny styl życia respondentów wymaga integracji interdyscyplinarnych działań edukacyjnych w tym zakresie.

19

Impact of pre-operative glycated haemoglobin A1C level on 1-year outcomes of endovascular treatment in patients with critical limb ischemia in the course of diabetes mellitus

75%

Wachsmann A., Maga M., Schönborn M., Olszewska M., Blukacz M., Cebeńko M., Trynkiewicz A., Maga P.

Folia Medica Cracoviensia

|

2019

|

vol. 59

|

issue 1

20

Charcot arthropathy in ultrasound examination – a case report

63%

Płaza M., Nowakowska-Płaza A., Walentowska-Janowicz M., Chojnowski M., Sudoł-Szopińska I.

Journal of Ultrasonography

|

2016

|

vol. 16

|

issue 65

210-215

EN

This article presents a patient with a long history of type 1 diabetes mellitus complicated with neuropathy and Charcot disease. The most common cause of neuropathic osteoarthropathy, called Charcot osteoarthropathy, is poorly controlled diabetes. The clinical picture is characterized by considerable edema, redness and increased skin temperature with relatively slight pain due to injury to nerve fibers responsible for pain sensation. The differential diagnosis should include bacterial or autoimmune arthritis, arthritis associated with gout as well as venous thrombosis and injury. The contribution of a local inflammatory reaction and abnormal bone turnover with excessive osteoclast activity might play a role in the etiopathogenesis of this disease. As a result, osseous and articular destruction progresses rapidly leading to irreversible deformity of the foot. Avoiding weight-bearing and resting the foot in a specially selected plaster cast is the most important part of treatment. Patients with the aforementioned complaints are referred to radiologists for imaging examinations. An ultrasonographer should pay attention to changes typical of Charcot arthropathy, such as: inflammatory and destructive changes in joints of the foot, uneven contour of bones with thickening and periosteal hyperemia as well as soft tissue swelling.

PL

Przedstawiamy opis przypadku pacjenta chorującego od wielu lat na cukrzycę typu 1 powikłaną neuropatią i artropatią Charcota. Najczęstszą przyczyną osteoartropatii neurogennej, zwanej osteoartropatią Charcota, jest źle wyrównana cukrzyca. W obrazie klinicznym zwraca uwagę znaczny obrzęk, zaczerwienienie oraz wzmożone ucieplenie stopy przy stosunkowo niewielkich dolegliwościach bólowych na skutek uszkodzenia włókien nerwowych przewodzących czucie bólu. W diagnostyce różnicowej należy uwzględnić zapalenie stawów o etiologii bakteryjnej, dnawej, autoimmunologicznej oraz zakrzepicę żylną i uraz. W etiopatogenezie choroby rozważa się udział miejscowej reakcji zapalnej i nieprawidłowy obrót kostny z nadmierną aktywacją osteoklastów. W efekcie dochodzi do szybko postępującej destrukcji struktur kostnych i stawowych oraz nieodwracalnych deformacji stopy. W leczeniu najważniejsze jest odciążenie stopy we wczesnej fazie choroby w specjalnie dobranym opatrunku gipsowym. Pacjenci z opisanymi wyżej dolegliwościami kierowani są na badania obrazowe. Ultrasonografista powinien zwracać uwagę na zmiany typowe dla artropatii Charcota, tj. zapalno-destrukcyjne w stawach stóp, a także nierówny zarys kości z obecnością pogrubienia i przekrwienia okostnej oraz obrzęk tkanek miękkich.

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The Effect of a Long-Term, Community-Based Exercise Program on Bone Mineral Density in Postmenopausal Women with Pre-Diabetes and Type 2 Diabetes

POZIOM WIEDZY I OCZEKIWANIA EDUKACYJNE CHOREGO NA CUKRZYCĘ TYPU 2 W ŚRODOWISKU WIEJSKIM

POZIOM WIEDZY I OCZEKIWANIA EDUKACYJNE CHOREGO NA CUKRZYCĘ TYPU 2 W ŚRODOWISKU WIEJSKIM

Impact of pre-operative glycated haemoglobin A1C level on 1-year outcomes of endovascular treatment in patients with critical limb ischemia in the course of diabetes mellitus

Charcot arthropathy in ultrasound examination – a case report