Search results

1

Treatment of multiple superficial basal cell carcinomas with topical imiquimod

100%

Brzeziński P., Chiriac A.

OncoReview

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2015

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vol. 5

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issue 1

A42-A45

EN

Basal cell carcinoma is the most common malignancy of man. The use of the topical imiquimod 5% cream offers a noninvasive, nonsurgical, and an effective option for the treatment of primary types superficial basal cell carcinoma (sBCC). We present a case series of patients who used imiquimod 5% cream with good therapeutic effect. The medication had a good tolerability profile and there were no ocular adverse events. Imiquimod 5% cream could be considered the first choice treatment for BCCs in older patients who are poor candidates to surgery.

2

Impact of 10 Sessions of Whole Body Cryostimulation on Cutaneous Microcirculation Measured by Laser Doppler Flowmetry

88%

Renata S., Tomasz D., Andrzej K., Sławomir T.

Journal of Human Kinetics

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2011

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vol. 30

75-83

EN

The aim of the present study was to evaluate the basic and evoked blood flow in the skin microcirculation of the hand, one day and ten days after a series of 10 whole body cryostimulation sessions, in healthy individuals.The study group included 32 volunteers - 16 women and 16 men. The volunteers underwent 10 sessions of cryotherapy in a cryogenic chamber. The variables were recorded before the series of 10 whole body cryostimulation sessions (first measurement), one day after the last session (second measurement) and ten days later (third measurement). Rest flow, post-occlusive hyperaemic reaction, reaction to temperature and arterio-venous reflex index were evaluated by laser Doppler flowmetry.The values recorded for rest flow, a post-occlusive hyperaemic reaction, a reaction to temperature and arterio - venous reflex index were significantly higher both in the second and third measurement compared to the initial one. Differences were recorded both in men and women. The values of frequency in the range of 0,01 Hz to 2 Hz (heart frequency dependent) were significantly lower after whole-body cryostimulation in both men and women. In the range of myogenic frequency significantly higher values were recorded in the second and third measurement compared to the first one.Recorded data suggest improved response of the cutaneous microcirculation to applied stimuli in both women and men. Positive effects of cryostimulation persist in the tested group for 10 consecutive days.

3

The Effects of Wetted Ice on Dynamic Stability over a Rewarming Period

88%

Alexander J., Mawene Y., Alexanders J., Jeffery J., Rhodes D.

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vol. 41

13-23

EN

BACKGROUND During half time or breaks in play cryotherapy is often applied for analgesia for minor musculoskeletal sport injury, however the effect of cryotherapy on dynamic stability is debated. A risk factor for further lower limb injury may be heightened due to a reduction in dynamic postural stability. OBJECTIVES The purpose of the current study was to investigate the effects of wetted-ice applied for 20-minutes at the ankle on dynamic stability using the star excursion balance test, immediately-post exposure and over a rewarming period of 30-minutes. MATERIALS AND METHODS Twenty-two healthy male athletes that regular took part in land-based sport were assessed on reach directions of Anterior (Ant), Posteromedial (PM), and Posterolateral (PL) using the modified star excursion balance test (mSEBT) on the non-dominant limb. Thermal imaging quantified skin surface temperature (Tsk) over lateral and medial regions. Participants were tested pre-intervention, exposed to 15-minutes wetted-ice cryotherapy application, immediately-post and up to 30-minutes post intervention at 10-minute intervals. RESULTS Significant decreases in Tsk over the medial and lateral regions of the ankle (p < 0.05) not returning to pre-cooling temperatures at 30-minutes post. Significant decrease in reach -distance scores (ANT, PL and PM) pre-immediately post and at 10, 20 and 30-minutes post cryotherapy exposure. CONCLUSION Following wetted ice application to the non-dominant ankle, dynamic postural stability was adversely affected for up to 30-minutes post exposure demonstrated through a decrease in reach scores for ANT, PL and PM directions. Functional performance which requires stabilising mechanisms may be negatively affected and contribute to a heightened risk of injury or further injury in consideration of the findings.

4

Comparison of three different techniques for eradication of Apple mosaic virus (ApMV) from hazelnut (Corylus avellana L.)

75%

Kaya E., Kaya E.

Journal of Plant Protection Research

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2021

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vol. 61

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issue 1

5

Wyniki stosowania krioterapii i aplikacji powidonu jodowanego w eradykacji przetrwałej infekcji wysokoonkogennymi typami HPV

75%

Markowska J., Sterlińska-Tulimowska B., Śmiertka W.

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issue 2

104-108

EN

Treatment covered 128 women aged 24–67 (37.5 on average), with abnormal cytology: in 77 patients atypical squamous cell of undetermined significance was detected, in 30 patients low-grade squamous intraepithelial lesions were identified while in 21 only the presence of koilocytes was demonstrated. In most cases, the cervix was without any clinical changes or ectropion lesions were detected. In all the patients, the presence of highly oncogenic human papillomavirus (HPV) was detected using viral genotyping reverse transcription polymerase chain reaction. In 45 (35%) patients, a single strain of HPV was detected, HPV 16 (40% of the patients) was most common. In 29 (22.6%) patients, two types of the virus were identified, most frequently HPV 16 or 18. In the remaining 54 (42.1%) patients, multiple types of HPV were detected. The employed therapeutic scheme involved two applications of cryotherapy with liquid nitrogen for 3 minutes, covering the mucosal surface (in the case of ectropion) with the transient zone and cervical canal. Following each application of cryotherapy, povidone-iodine (Betadine) globules were used. In 7 patients, electrocoagulation using the LEEP system was additionally performed (in the case of bleeding ectropion). Two months after the last procedure, HPV was marked again using the RT-PCR method. HPV was not detected in any of the treated patients. In 10 patients due to persistent ectropion lesion on the cervix, electroconization was conducted and histopathology demonstrated no HPV-related lesions. Cryotherapy – accompanied by the application of povidone-iodine – is effective in the prophylaxis and eradication of persistent infection with highly oncogenic HPV.

PL

Leczeniem objęto 128 kobiet w wieku 24–67 lat (średnio 37,5 roku), u których stwierdzono nieprawidłowy wynik badania cytologicznego: u 77 pacjentek – atypowe komórki nabłonka wielowarstwowego płaskiego o nieokreślonym znaczeniu, u 30 – śródnabłonkowe zmiany dysplastyczne niskiego stopnia, a u 21 – jedynie obecność koilocytów. Klinicznie szyjka macicy w większości przypadków nie wykazywała zmian lub wykazywała zmiany o charakterze ektropii. U wszystkich kobiet metodą reakcji łańcuchowej polimerazy z odwrotną transkryptazą wykryto obecność wysokoonkogennych typów wirusa brodawczaka ludzkiego. U 45 (35%) pacjentek odnotowano pojedyncze typy, w tym najczęściej HPV 16 (40% grupy). U 29 (22,6%) osób wykryto dwa typy wirusa; jednym z nich był najczęściej HPV 16 lub 18. U pozostałych 54 (42,1%) kobiet stwierdzono mnogie typy HPV. Stosowano schemat leczenia polegający na dwukrotnej krioterapii ciekłym azotem przez 3 minuty – obejmującej zmianę na tarczy (jeśli występowała ektropia) ze strefą przejściową i kanał szyjki macicy. Po każdej krioterapii stosowano globulki powidonu jodowanego (Betadine). U siedmiu pacjentek dodatkowo wykonano koagulację systemem LEEP (w przypadku krwawiącej ektropii). Po 2 miesiącach od ostatniego zabiegu ponownie oznaczano HPV metodą reakcji łańcuchowej polimerazy z odwrotną transkryptazą – u żadnej z kobiet nie wykryto obecności HPV. U 10 pacjentek ze względu na przetrwałą zmianę typu ektropii wykonano elektrokonizację; ocena histopatologiczna nie wykazała zmian związanych z HPV. Krioterapia połączona ze stosowaniem powidonu jodowanego jest skuteczna w profilaktyce i eradykacji przetrwałej infekcji wysokoonkogennymi typami HPV.

6

The impact of kinesiotherapy on blood pressure in patients undergoing systemic cryotherapy treatment

75%

Drozd A., Kalmus P.

Advances in Rehabilitation

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2013

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vol. 27

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issue 4

21-29

EN

Introduction: It is proven that the influence it has when used locally is anti-inflammatory, analgesic, antiedematous, it reduces muscle tension and improves blood circulation. It has overall beneficial effect in systemic use. Cryotherapy causes strong reactions involving their vascular spasm, with the dynamic relaxation after that. Cryotherapy treatment is recommended e.g. in cases of musculoskeletal diseases, the diseases of the nervous system and depressive disorders. There are many medical contraindications to the use of cryotherapy treatment, especially to systemic cryotherapy treatment. One of them is unregulated high blood pressure (hypertension). The aim of this study was to analyze the impact of systemic cryotherapy treatment followed by kinesiotherapy on the behavior of blood pressure on the patients with normal blood pressure, and patients with high blood pressure. Material and methods: For this study it was examined 51 patients, including men and women. 45% of them were also diagnosed with hypertension. All patients were undergoing 10 systemic cryotherapy treatments following normal procedure. Immediately after cryotherapy treatment, each patient was directed to the kinesiotherapy treatment. During the study, blood pressure measurements were made. The results of blood pressure measurements were statistically analyzed for the entire study group, for the group of patients diagnosed without hypertension and for the group with hypertension. Results: Comparison of changes in the behavior of the blood pressure in each group of patients showed that after a series of 10 treatments, there was a decrease of blood pressure (both, systolic and diastolic). Among all patients and in the group of patients with hypertension, there was a clear tendency to increase of systolic blood pressure in each case immediately after cryotherapy. In all groups of patients, after kinesiotherapy there was a tendency to decrease the blood pressure. Conclusions: The results showed that a series of systemic cryotherapy treatments followed by kinesiotherapy causes reduction of systolic and diastolic blood pressure on patients without hypertension, and patients with diagnosed and well-controlled hypertension. Patients with high blood pressure during systemic cryotherapy treatment should undergo a special medical care.

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