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A quantitative analytical investigation on the oxycodone side effects listed in recent clinical trials

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Toussi A. G., Toosi F. G.

European Journal of Translational and Clinical Medicine

2023

vol. 6

issue 1

58-63

Background: Oxycodone is a semi-synthetic narcotic analgesic medication with numerous side eefcts. Patients who use oxycodone may have one or more side eefcts depending on their clinical status and/or other factors. Our aim was to analyze clinical trials for any potential paetrn related to the side eefcts of oxycodone. Methods: We searched the ClinicalTrials.gov database for clinical studies conducted around the world regarding oxycodone. A number of general data analytic and text manipulation techniques were used in the Python programming language. Results: We analyzed 842 clinical trials involving oxycodone. Our results suggest that the researchers focused on oxycodone's typical side eefcts (e.g. vomiting), as opposed to the less evident and/or long-term side eefcts e.g. depression, confusion and constipation. Conclusions: The adverse eefcts of oxycodone most commonly reported in the clinical trials are nausea, vomiting and depression. Despite the clinical use of oxycodone in all the age groups (including infants), very few of the publicly-available clinical trials included participants < 18 years of age. Toussi AG, Toosi FG. A quantitative analytical investigation on the oxycodone side eefcts listed in recent clinical trials. Eur J Transl Clin Med. 2023;6(1):58-63.

THE NEUROLOGICAL CONSEQUENCES OF CONTRACTING COVID-19

58%

Aknin L. B., De Neve J. E., Dunn E. W., Fancourt D. E., Goldberg E., Helliwell J. F., Jones S. P., Karam E., Layard R., Lyubomirsky S., Rzepa A., Saxena S., Thornton E. M., VanderWeele T. J., Whillans A. V., Zaki J., Caman O., Amor Y. B.

Acta Neuropsychologica

2021

vol. 19(3)

301-305

Since the first confirmed case in Wuhan, China on December 31, 2019, the novel coronavirus (SARS-CoV-2) has spread quickly, infecting 165 million people as of May 2021. Since this first detection, research has indicated that people contracting the virus may suffer neurological and mental disorders and deficits, in addition to the respiratory and other organ challenges caused by COVID-19. Specifically, early evidence suggests that COVID-19 has both mild (e.g., loss of smell (anosmia), loss of taste (ageusia), latent blinks (heterophila), headaches, dizziness, confusion) and more severe outcomes (e.g., cognitive impairments, seizures, delirium, psychosis, strokes). Longer-term neurological challenges or damage may also occur. This knowledge should inform clinical guidelines, assessment, and public health planning while more systematic research using biological, clinical, and longitudinal methods provides further insights.

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1 Acta Neuropsychologica

1 European Journal of Translational and Clinical Medicine

1 2023

1 2021

1 Aknin L. B.

1 Amor Y. B.

1 Caman O.

1 De Neve J. E.

1 Dunn E. W.

1 Fancourt D. E.

1 Goldberg E.

1 Helliwell J. F.

1 Jones S. P.

1 Karam E.

1 Layard R.

1 Lyubomirsky S.

1 Rzepa A.

1 Saxena S.

1 Thornton E. M.

1 Toosi F. G.

1 Toussi A. G.

1 VanderWeele T. J.

1 Whillans A. V.

1 Zaki J.

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A quantitative analytical investigation on the oxycodone side effects listed in recent clinical trials

THE NEUROLOGICAL CONSEQUENCES OF CONTRACTING COVID-19