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Bistability of Feshbach resonance in optical cavity

100%
Open Physics
|
2014
|
vol. 12
|
issue 6
427-432
EN
We consider Feshbach resonance in an optical cavity where photons interact with atoms and molecules dispersively. From mean-field theory we obtain multiple fixed-point solutions, which is strongly related to the phenomenon of bistability. Adiabatic evolutions demonstrate hysteretic behaviors by varying pump-cavity detuning from opposite directions. We also use the quantum model to check mean-field results which match perfectly. The analysis here may enrich the study of particle-photon interaction systems.
2
75%
Open Physics
|
2010
|
vol. 8
|
issue 6
864-872
EN
In eukaryotic cells, protein-coding sequences constitute a relatively small part of the genome. The rest of the genome is transcribed to non-coding RNAs (ncRNAs). Such RNAs form the cornerstone of a regulatory network that operates in parallel with the protein network. Their biological functions are based primarily on the ability to pair with and deactivate target messenger RNAs (mRNAs). To clarify the likely role of ncRNAs in complex genetic networks, we present and comprehensively analyze a kinetic model of one of the key counterparts of the network architectures. Specifically, the genes transcribed to ncRNAs are considered to interplay with a hierarchical two-layer set of genes transcribed to mRNAs. The genes forming the bottom layer are regulated from the top and negatively self-regulated. If the former regulation is positive, the dependence of the RNA populations on the governing parameters is found to be often non-monotonous. Specifically, the model predicts bistability. If the regulation is negative, the dependence of the RNA populations on the governing parameters is monotonous. In particular, the population of the mRNAs, corresponding to the genes forming the bottom layer, is nearly constant.
3
Content available remote

Interplay of viral miRNAs and host mRNAs and proteins

75%
Open Physics
|
2011
|
vol. 9
|
issue 5
1366-1371
EN
Recent experiments indicate that several viruses may encode microRNAs (miRNAs) in cells. Such RNAs may interfere with the host mRNAs and proteins. We present a kinetic analysis of this interplay. In our treatment, the viral miRNA is considered to be able to associate with the host mRNA with subsequent degradation. This process may result in a decline of the mRNA population and also in a decline of the population of the protein encoded by this mRNA. With these ingredients, we first show the types of the corresponding steady-state kinetics in the cases of positive and negative regulation of the miRNA synthesis by the protein. In addition, we scrutinize the situation when the protein regulates the virion replication or, in other words, provides a feedback for the replication. For the negative feedback, the replication rate is found to increase with increasing the intracellular virion population. For the positive feedback, the replication rate first increases and then drops. These features may determine the stability of steady states.
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