Search results

1

POTENTIAL USE OF CHITOSAN – BASED MATERIALE IN MEDICINE

100%

Kucharska M., Ciechańska D., Niekraszewicz A., Wiśniewska-Wrona M., Kardas I.

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vol. 15

169 - 176

EN

Polysaccharides are macromolecular polymers that manifest ability toward the forming of fibres, film and coatings. Some of their specific properties like biodegradability and biocompatibility make them suitable for medical application. Chitin, chitosan and alginates are basic polymers mostly used in the preparation of medical biomaterials. In the Institute of Biopolymers and Chemical Fibres (IBWCh) multidirectional investigations are in full swing concerned with the use medical of polysaccharides and their various useful forms. The research includes amongst: multifunctional dressing materials, implants and other polysaccharide biomaterials.

2

BIOMATERIALS BASED ON CHITOSAN AND ITS DERIVATIVES TO PREVENT ADHESION FORMATION

88%

Konovalova M., Tsaregorodtseva D., Svirshchevskaya E.

Progress on Chemistry and Application of Chitin and its Derivatives

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2021

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vol. 26

11-22

EN

An increase in the number and volume of surgical interventions leads to an increase in the frequency of postoperative adhesions. The development of the adhesion process in the abdominal cavity causes pain, a decrease in the quality of life of patients, a violation of the reproductive function of women as well as acute adhesion intestinal obstruction. Recently, polymer biomaterials, including those based on chitosan, have been widely used for the prevention of adhesions. Due to their biocompatibility and biodegradation ability, they do not require repeated operations to extract the material. It is believed that these materials act as barriers, physically separating the damaged surfaces. The molecular mechanism of their action is still poorly understood. In this review, the main mechanisms of adhesion formation, as well as ways to prevent them with the help of materials based on chitosan and its derivatives, are discussed

3

Structural and morphological properties of HA-ZnO powders prepared for biomaterials

88%

Moldovan M., Prodan D., Popescu V., Prejmerean C., Saroși C., Saplonţai M., Țălu S., Vasile E.

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issue 1

EN

The purpose of this study was to investigate the structural and morphological properties of hydroxyapatite – zinc oxide (HA-ZnO) powders prepared to be used in an endodontic sealer formulation. The HA-ZnO was synthesized from hydroxyapatite (HA) in the presence of zinc oxide (ZnO) sol. The starting reagents were CaO, H3PO4 and a suspention of ZnO (25% in water). Following precipitation, the obtained sol was subjected to heat treatment at 110°C, 400°C, 850°C and 1050°C. The study focused on the influence of the thermal treatment on the cristallinity of precipitated powders. X-ray diffraction was used in order to study the structural properties of the obtained powder. Fourier Transform Infrared Spectroscopy (FT-IR) was used in order to evaluate the interactions between HA and ZnO. The morphology of the samples was studied by Scanning Electron Microscopy (SEM). Transmission Electron Microscopy and High Resolution Transmission Electron Microscopy (TEM, HRTEM) were used for the determination of particle size and fractal analysis. The fractal analysis of images using the standard box-counting method is presented and the results are discussed. It was demonstrated that the fractal dimension analysis is a useful method to quantitatively describe the complex microstructures and it can reveal the relation between fractal parameters.

4

The Influence of Plastic Forming Processes on the Dissolution Rate of Biocompatible Mg Alloys

88%

Boczkal S., Karaś M., Korczak P., Kapinos D., Koprowski P., Szymański W., Wroński S.

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issue 3

5

Properties Comparison of Intraperitoneal Hernia Meshes in Reconstruction of the Abdominal Wall - Animal Model Study

88%

Ławniczak P., Grobelski B., Pasieka Z.

Polish Journal of Surgery

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2011

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vol. 83

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issue 1

19-26

EN

Modern methods of hernia tension free treatment use very wide range of modern biomaterials. Most of them are used transabdominal. For the best and most convenient treatment of large hernias would be a mesh suitable for intraperitoneal use with low adhesion ability to internal organs.The aim of the study was to compare three types of intraperitoneal meshes.Material and methods. The study compared three types of intraperitoneal meshes. Sub-chronic (14 days) and chronic (90 days) macro-and microscopic examination were performed on rats (n = 69). Properties of the polypropylene mesh (PLP), Dynamesh®-iPOM and polypropylene covered with chitosan (PLP+chitosan) were evaluated and compared.Results. It has been shown that the test meshes differ slightly during the healing process.Conclusion. The PLP+chitosan mesh had the best biocompatible features of them all.

6

Towards microfluidics for mycology – material and technological studies on LOCs as new tools ensuring investigation of microscopic fungi and soil organisms

75%

Podwin A., Janisz T., Patejuk K., Szyszka P., Walczak R., Dziuban J., Podwin A., Janisz T., Patejuk K., Szyszka P., Walczak R., Dziuban J.

Bulletin of the Polish Academy of Sciences: Technical Sciences

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2021

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issue 1

7

Optimizing the conditions of PGSu synthesis with simplex method

75%

Wrzecionek M., Howis J., Ruśkowski P., Gadomska-Gajadhur A., Wrzecionek M., Howis J., Ruśkowski P., Gadomska-Gajadhur A.

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vol. 41

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issue 2

8

STRUCTURAL AND BIOLOGICAL CHARACTERISTICS OF SELF-ORGANISING CHITOSAN HYDROGELS

75%

Pieklarz K., Tylman M., Modrzejewska Z., Galita G., Majsterek I.

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EN

Creating innovative methods of treatment and regeneration of damaged tissues or organs is a key challenge of the twenty-first century. The aim of this study was to determine the possibility of producing and characterising the properties of self-organising chitosan hydrogels prepared with the use of chitosan lactate/chloride and disodium hydrogen phosphate dodecahydrate as a cross-linking agent. The structure and supramolecular architecture of the biomaterials were evaluated by Fourier-transform infrared spectroscopy and polarised optical microscopy. Biological studies assessed cytotoxicity by contact with a human colon adenocarcinoma cell line. The colourimetric resazurin assay showed that the obtained chitosan hydrogels are non-cytotoxic materials. Thus, self-organising biomaterials hold great promise for application in tissue engineering.

9

The Formation of Polycomplexes of Poly(Methyl Vinyl Ether-Co-Maleic Anhydride) and Bovine Serum Albumin in the Presence of Copper Ions

75%

Karahan M., Mustafaeva Z., Özeroğlu C.

Polish Journal of Chemical Technology

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2014

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vol. 16

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issue 3

97-105

EN

The binary and ternary complex formations of poly(methyl vinyl ether-co-maleic anhydride) (PMVEMA) with copper ions and with bovine serum albumin (BSA) in the presence of copper ions in phosphate buffer solution at pH = 7 were examined by the techniques of UV-visible, fluorescence, dynamic light scattering, atomic force microscopy measurements. In the formation of binary complexes of PMVEMA-Cu(II), the addition of copper ions to the solution of PMVEMA in phosphate buffer solution at pH = 7 forms homogeneous solutions when the molar ratio of Cu(II)/MVEMA is 0.5. Then the formations of ternary complexes of PMVEMA-Cu(II)-BSA were examined. Study analysis revealed that the toxicities of polymer-metal and polymer-metal-protein mixture solutions depend on the nature and ratio of components in mixtures.

10

Struktura, funkcja i znaczenie biomedyczne kolagenów

63%

Czubak K. A., Żbikowska H. M.

Annales Academiae Medicae Silesiensis

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2014

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vol. 68

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issue 4

245-254

EN

Collagens are a family of fibrous proteins which are a major component of the extracellular matrix (ECM) in animal organisms. These proteins are found in most tissues and organs (bones, cartilages, skin, ligaments, tendons, corneas). The main functions of collagens include the maintenance of structural integrity, elasticity and tensile strength of the connective tissue. Macromolecules from the collagen family are characterized by a unique structure rich in e.g. glycine, proline and hydroxyproline. The collagen structure consists of three left-handed polypeptide chains which are coiled around each other forming a right-handed rope-like super helix. This structure is stabilized by the presence of interstrand hydrogen bonds. To date, 29 types of collagen have been isolated and described. They differ from each other in structure, functions, and body distribution. Research development has allowed us to understand the structure and properties of native collagens which has resulted in the production of artificial collagen fibrils used in nanotechnology and biomedicine. Collagen materials are considered to be the most useful biomaterials in medicine

PL

Kolageny to rodzina białek fibrylarnych, będąca głównym składnikiem macierzy zewnątrzkomórkowej organizmów zwierzęcych. Białka te występują w większości tkanek i narządów, m.in. w kościach, chrząstkach, skórze, więzadłach, ścięgnach, rogówce. Podstawowym ich zadaniem jest utrzymanie integralności strukturalnej i sprężystości tkanki łącznej oraz jej wytrzymałości na rozciąganie. Kolageny charakteryzują się unikatową strukturą bogatą w aminokwasy, takie jak glicyna i prolina oraz hydroksyprolina. Głównym elementem struktury kolagenów są 3 lewoskrętne polipeptydowe łańcuchy, nawijające się wokół siebie i tworzące prawoskrętną konformację liny superhelisowej, która utrzymywana jest dzięki obecności wiązań wodorowych. Dotychczas udało się wyizolować i opisać 29 typów kolagenów charakteryzujących się odmienną strukturą, funkcją oraz występowaniem w organizmie. Rozwój technik badawczych umożliwił poznanie struktury i właściwości naturalnych białek kolagenowych, co z kolei zaowocowało produkcją syntetycznych włókien kolagenowych, wykorzystywanych w nanotechnologii czy biomedycynie. Materiały kolagenowe zaliczane są do najbardziej użytecznych biomateriałów ze względu na takie właściwości, jak minimalna toksyczność, niska antygenowość, wysoka biozgodność oraz biodegradowalność.

11

Jak chronić biomateriały przed układem odpornościowym?

51%

Ścisłowska-Czarnecka A., Kołaczkowska E.

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PL

Wprowadzając do organizmu człowieka biomateriał, musimy mieć pewność, że jest on biozgodny (nie cytotoksyczny czy karcynogenny) i że ryzyko aktywacji układu odpornościowego jest niewielkie. Grupa biomateriałów dopuszczonych do użytku medycznego jest obszerna, jednak wiele z nich nie spełnia jednocześnie wszystkich wymagań w zakresie biozgodności. Dlatego materiały przeznaczone do użytku medycznego są wciąż udoskonalane/modyfikowane w celu poprawy ich parametrów, a co za tym idzie, w celu ich jak najskuteczniejszego "ukrycia" przed układem odpornościowym. Jedną z najczęstszych, niepożądanych reakcji organizmu na biomateriał/implant jest odczyn zapalny. Dlatego wiele badań koncentruje się na wpływie implantów na komórki układu odpornościowego. Wykazano, że najczęściej obecnie stosowane modyfikacje biomateriałów, pokrycie ich powierzchni materiałem biologicznym, zmiana porowatości czy też dodatek nanocząsteczek, istotnie poprawiają ich właściwości, w tym osłabiają aktywację leukocytów. W obecnym opracowaniu opisujemy typy biomateriałów, sposoby ich modyfikacji oraz wpływ na komórki immunokompetentne z naciskiem na strategie, które pozwalają na uniknięcie aktywacji układu odpornościowego.

EN

Biocompatibility verification is required prior to implantation of any biomaterial into human body. This involves verification of its cytotoxic and carcinogenic effects, and confirmation of (only) weak activation of the immune system. A substantial number of biomaterials is currently used in medical procedures, however, many of them do not fulfill all biocompatibility requirements. Therefore nowadays materials aimed for medical application are being modified to improve their characteristics, and thus "hide" them more efficiently from the immune system. One of the most common, yet undesirable, responses to biomaterial/implant is inflammation. Because of this, numerous studies focus on immune cells and strategies to modify biomaterials in such ways that they induce only weak or mild, and short-lasting, activation of leukocytes. It has been documented that three approaches in particular are efficient in this regard - surface modification by its covering with biological substances/proteins, modification of surface porosity and addition of nanoparticles. Herein we described types of biomaterials, strategies of their modification and biomaterial impact on leukocytes. In particular, we focus on strategies used to minimize activation of the immune response.

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POTENTIAL USE OF CHITOSAN – BASED MATERIALE IN MEDICINE

BIOMATERIALS BASED ON CHITOSAN AND ITS DERIVATIVES TO PREVENT ADHESION FORMATION

Structural and morphological properties of HA-ZnO powders prepared for biomaterials

The Influence of Plastic Forming Processes on the Dissolution Rate of Biocompatible Mg Alloys

Properties Comparison of Intraperitoneal Hernia Meshes in Reconstruction of the Abdominal Wall - Animal Model Study

Towards microfluidics for mycology – material and technological studies on LOCs as new tools ensuring investigation of microscopic fungi and soil organisms

Optimizing the conditions of PGSu synthesis with simplex method

STRUCTURAL AND BIOLOGICAL CHARACTERISTICS OF SELF-ORGANISING CHITOSAN HYDROGELS

The Formation of Polycomplexes of Poly(Methyl Vinyl Ether-Co-Maleic Anhydride) and Bovine Serum Albumin in the Presence of Copper Ions

Struktura, funkcja i znaczenie biomedyczne kolagenów

Jak chronić biomateriały przed układem odpornościowym?