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1

A multicarotenoid beadlet for human nutrition - proof of concept of in vitro timed release

100%

Gellenbeck K., Salter-Venzon D., Lala R., Chavan J.

Acta Biochimica Polonica

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2012

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vol. 59

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issue 1

35-38

EN

Since the 1980's when the predominate focus of study and use of carotenoids in human nutritional formulations was solely on beta-carotene, there has been a steady increase in research aimed to understand the role of a wide variety of carotenoids in human health. This work has increasingly demonstrated the benefits of a number of carotenoids, and there has been a corresponding increase in the number of carotenoids provided in nutritional supplements (multicarotenoids). Numerous published observations in both human and animal studies suggest significant interaction and competition between various carotenoids during absorption and metabolism, resulting in the inhibition of uptake of one over the other. This competition has the end result of reducing the beneficial effects of the inhibited carotenoid. To limit such competition and maximize carotenoid uptakes, a layered beadlet was designed to release a defined ratio of carotenoids sequentially. Preliminary dissolution testing is presented showing the release profile in simulated digestive conditions of a combination of beta-carotene, alpha carotene, lutein, zeaxanthin, lycopene and astaxanthin derived from natural sources. Comparison is made to an immediate release beadlet formulation using the same combination of carotenoids. These results will be used to guide proof of concept clinical testing for effectiveness in humans.

2

Glaucoma and generics in Europe

88%

Hommer A.

OphthaTherapy

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2019

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vol. 6

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issue 1

31-36

EN

Original drugs and generic drugs used in glaucoma differ from each other. This can lead to worse drug tolerability and, as a result, to worse patients’ compliance. Therefore, an essential issue is, besides the drug’s efficacy, its optimal tolerability for the patient. The potential differences in viscosity, pH, drop size, and surface tension has a potential strong influence on the complex delivery mechanism of the active molecule to the receptors in the eye and its clinical relevant efficacy. These differences, in addition to different appearance and handling of a “new” bottle, may pose problems with patients’ compliance after using a new preparation.

PL

Oryginalne leki i leki generyczne stosowane w jaskrze różnią się od siebie. Może to prowadzić do gorszej tolerancji na leki i w rezultacie do pogorszenia przestrzegania zaleceń przez pacjentów. Dlatego istotną kwestią jest, oprócz skuteczności leku, jego optymalna tolerancja ze strony pacjenta. Ewentualne różnice w lepkości, pH, wielkości kropli i napięciu powierzchniowym mogą mieć istotny wpływ na dostarczanie aktywnej cząsteczki do receptorów w oku i jej klinicznie istotną skuteczność. Różnice te, poza różnym wyglądem i obsługą „nowej” butelki, mogą powodować problemy z przestrzeganiem zaleceń przez pacjentów w przypadku zastosowania nowego preparatu.

3

Bioavailability of hydrocarbons to bacterial consortia during Triton X-100 mediated biodegradation in aqueous media

88%

Pęziak D., Piotrowska A., Marecik R., Lisiecki P., Woźniak M., Szulc A., Ławniczak Ł., Chrzanowski Ł.

Acta Biochimica Polonica

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2013

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vol. 60

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issue 4

789-793

EN

The aim of our study was to investigate the effect of Triton X-100 on the biodegradation efficiency of hexadecane and phenanthrene carried out by two bacterial consortia. It was established that the tested consortia were not able to directly uptake compounds closed in micelles. It was observed that in micellar systems the nonionic synthetic surfactant was preferentially degraded (the degradation efficiency of Triton X-100 after 21 days was 70% of the initial concentration - 500 mg/l), followed by a lesser decomposition of hydrocarbon released from the micelles (30% for hexadecane and 20% for phenanthrene). However, when hydrocarbons were used as the sole carbon source, 70% of hexadecane and 30% of phenanthrene were degraded. The degradation of the surfactant did not contribute to notable shifts in bacterial community dynamics, as determined by Real-Time PCR. The obtained results suggest that if surfactant-supplementation is to be used as an integral part of a bioremediation process, then possible bioavailability decrease due to entrapment of the contaminant into surfactant micelles should also be taken into consideration, as this phenomenon may have a negative impact on the biodegradation efficiency. Surfactant-induced mobilization of otherwise recalcitrant hydrocarbons may contribute to the spreading of contaminants in the environment and prevent their biodegradation.

4

Pharmacokinetics of the recombinant ovine interferon-tau in lambs

88%

Zhao J., Yu H. Y., Zhao Y., Li S. Q., Fu X. L., Zhou W., Xia B. B., Wang M. L., Chen J., Zhao J., Yu H. Y., Zhao Y., Li S. Q., Fu X. L., Zhou W., Xia B. B., Wang M. L., Chen J.

Polish Journal of Veterinary Sciences

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2019

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issue 1

5

Pharmacokinetics of diclofenac sodium injection in swine

75%

Yang H. F., Li Y. J., Li Y. Y., Huang C., Huang L. X., Bu S. J., Yang H. F., Li Y. J., Li Y. Y., Huang C., Huang L. X., Bu S. J.

Polish Journal of Veterinary Sciences

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2019

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issue 2

6

Bioavailability of mesalazine from two coated formulation tablets

75%

Hermann T. W., Główka F. K., Hermann J., Zabel M.

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2019

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vol. 76

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issue 1

67-73

EN

HPLC methodology with a fluorescent detector is suitable for bioavailability studies of investigated generic tablets Mesalazine 250 mg (Jelfa, Poland) versus standard Salofalk tablets (Dr. Falk, Germany). The investigations were completed in ten healthy subjects in a double way crossover design. Only one bioavailability parameter – time for maximum mesalazine plasma concentration (tmax ) and overall elimination rate constants are significantly greater for the above standard tablets. The parameters like maximum plasma drug concentration (Cmax), lag time for absorption (Tlag), biological half-life time (t1/2 ) are also more favorable for the standard, but these values are not significantly different.

Refine search results

A multicarotenoid beadlet for human nutrition - proof of concept of in vitro timed release

Glaucoma and generics in Europe

Bioavailability of hydrocarbons to bacterial consortia during Triton X-100 mediated biodegradation in aqueous media

Pharmacokinetics of the recombinant ovine interferon-tau in lambs

Pharmacokinetics of diclofenac sodium injection in swine

Bioavailability of mesalazine from two coated formulation tablets