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1

Phytoconstitution and Antioxidant Activity of the Ethanolic Extract of an Antimalarial Herbal Mixture

100%

Odokwo E. O., Onifade M. S.

World News of Natural Sciences

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2024

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vol. 54

38-44

EN

The phytoconstitution and antioxidant profiling of mixture of herbs used in the treatment of malaria has been carried out. Herbs used as alternative medicines in the local treatment of malaria were collected from a herbal vendor in Ibadan. The herbal materials were extracted using absolute ethanol and the crude extract, EEA subjected to qualitative phytochemical screening and 2,2-diphenyl-1-picrylhydrazyl (DPPH) standard procedures. The presence of alkaloids, saponins, tannins, terpeniods, flavonoids and phenols were identified. EEA was found to exhibit antioxidant activity in the dose range of 25-400 μgml-1. The significant presence of major series of phytochemicals has justified the associated antimalarial ethnomedicinal claim. Thus, the present study has established the phytoconstitution and antioxidant activity of an antimalaria herbal mixture.

2

Antioxidant effects of carotenoids in a model pigment-protein complex

100%

Fiedor J., Sulikowska A., Orzechowska A., Fiedor L., Burda K.

Acta Biochimica Polonica

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2012

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vol. 59

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issue 1

61-64

EN

The effect of carotenoids on stability of model photosynthetic pigment-protein complexes subjected to chemical oxidation with hydrogen peroxide or potassium ferricyanide was investigated. The oxidation of carotenoid-less and carotenoid-containing complexes was conducted in the presence or absence of ascorbic acid. The progress of the reactions was monitored by use of absorption and fluorescence spectroscopy. Our results show that carotenoids may significantly enhance the stability of photosynthetic complexes against oxidation and their protective (antioxidant) effect depends on the type of the oxidant.

3

Can angiotensin-converting enzyme inhibitors interfere with the free radicals? Measurement of antioxidant capacity using DPPH radical reduction examined by UV-VIS method

100%

Ramos P., Juszczak A., Szczołko W., Pilawa B., Stanisz B. J.

Acta Poloniae Pharmaceutica - Drug Research

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2019

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vol. 76

|

issue 2

233-239

EN

A negative impact of radicals on human’s health is responsible for growing research interest in antioxidant properties of substances, which protect organisms from the damaging influence of these reactive species. Angiotensin-converting enzyme inhibitors (ACE-I) are the most popular drugs used in cardiovascular diseases. There are a lot of clinical reports that ACE-I have antioxidant properties, due to the fact, that prolonged use improves conditions of patients with neurodegenerative disorders and slow inflammatory processes. The paper shows the antioxidant properties of a selected ACE-I: cilazapril, ramipril, imidapril, lisinopril, perindopril, and quinapril. Among numerous methods for antioxidant activity estimation, DPPH reduction is the most popular and commonly used one due to its ease, speed, sensitivity and the usage of stable radicals. UV-Vis spectrophotometry was used to examine interactions of chosen ACE-I with model-free radicals. Absorption of UV-Vis spectra of DPPH (reference), and DPPH interacting with the tested ACE-I were compared. For all tested ACE-I kinetics of their interaction with DPPH, up to 30 minutes, were obtained. The strongest interaction with DPPH was observed for imidapril and cilazapril and the lowest interaction for lisinopril. Studies have shown usefulness UV-Vis spectrophotometry for obtaining information on interactions of ACE-I with model-free radicals.

4

Comparison of chemical composition and biological activities of Seseli rigidum fruit essential oils from Serbia

100%

Ilić M. D., Jovanović V. P. S., Mitić V. D., Jovanović O. P., Mihajilov-Krstev T. M., Marković M. S., Stojanović G. S.

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issue 1

EN

Plants from genus Seseli, have been widely used in European traditional medicine, exhibiting antibacterial, antifungal, insect repellent, emmenogogue, antiflatulence, anti-inflammatory, antinociceptive, anti-tumor, antirheumatic activities and protective effect on human lymphocytes DNA. They usually grow on mountain rocky terrains. Part of their habitat on Vidlic Mountain, located in South-east Serbia, was struck with a large wildfire. Seseli rigidum fruit essential oils (from post fire and control areas) compositions were analyzed by GC and GC-MS, identifying monoterpenes α-pinene and sabinene as most abundant. Statistical tests showed a non-significant difference in chemical composition of these two oils, but a significant difference in comparison with the herb from a geographically different origin. Antimicrobial tests showed strong activities of the oils against tested bacteria, thus confirming its administration in various inflammation processes as a quite effective remedy. Applying DPPH. and ABTS+. radical scavenging and total reducing Fe(III) to Fe(II) power assays, antioxidant characteristics of both studied essential oils were estimated as weak, though of close values. Seseli rigidum fruit essential oil was proven as a potent inhibitor of human and horse serum cholinesterase, recognizing its possible application as neural protective agent

5

QSAR modeling of antiradical and antioxidant activities of flavonoids using electrotopological state (E-State) atom parameters

100%

Ray S., Sengupta C., Roy K.

Open Chemistry

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2007

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vol. 5

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issue 4

1094-1113

EN

In the present paper QSAR modeling using electrotopological state atom (E-state) parameters has been attempted to determine the antiradical and the antioxidant activities of flavonoids in two model systems reported by Burda et al. (2001). The antiradical property of a methanolic solution of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and the antioxidant activity of flavonoids in a β-carotenelinoleic acid were the two model systems studied. Different statistical tools used in this communication are stepwise regression analysis, multiple linear regressions with factor analysis as the preprocessing step for variable selection (FA-MLR) and partial least squares analysis (PLS). In both the activities the best equation is obtained from stepwise regression analysis, considering, both equation statistics and predictive ability (antiradical activity: R 2 = 0.927, Q2 = 0.871 and antioxidant activity: R 2 = 0.901, Q2 = 0.841). [...]

6

Current concepts in pathophysiology and management of hepatocellular carcinoma

88%

Hamza A., Abdulfattah H., Mahmoud R., Khalil W., Ahmed H.

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issue 3

573-580

EN

Additional approaches to control malignancies are needed due to the emerging trends in the incidence of cancer of different organ sites. Due to the high frequency of hepatocellular carcinoma (HCC) and its poor prognosis, preventing HCC is an urgent priority. To explore the antioxidant and apoptotic pathways of grape seed extract (GSE) we induce HCC experimentally by diethylnitrosoamine (DEN) and treated the animals with low and high doses of GSE. The results indicate good therapeutic possibilities for GSE use in treatment of HCC., This was evidenced via regression of liver enzymes' function (ALT&AST), the HCC markers; α-fucosidase, α-fetoprotein and carcinoembrionic antigen (CEA) in HCC groups treated with the grape seed extract. Also, tumor necrosis factor (TNF-α) showed a significant decrease using GSE in HCC bearing animals. Regarding the apoptotic pathways of GSE, we found a significant down regulation of apoptosis enhancing nuclease (Aen), Bcl2-associated X protein (Bax), B-cell translocation gene 2(Btg2), Cyclin G1 (Ccng1) and Cyclin-dependent kinase inhibitor 1A (Cdkn1a) gene expression in HCC+GSE groups as compared to HCC bearing group. In the same trend, the necrotic/apoptotic rates were significantly higher in the HCC groups treated with GSE vs. the HCC bearing group. Finally, the 8-OHdG/2-dG generation decreased by 73.8% and 52.9% in HCC+GSE at low and high doses, respectively. Based on these encouraging observations, grape seed extract could be a promising natural remedy for attenuating hepatocellular carcinoma that has a great future in approaches directed towards control of HCC.

7

Dose-effect relationship on anti-inflammatory activity on LPS induced RAW 264.7 cells and antioxidant activity of rutin in vitro

88%

tian c., guo y., chang y., zhao j., cui c., liu m.

Acta Poloniae Pharmaceutica - Drug Research

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2019

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vol. 76

|

issue 3

511-522

EN

Rutin, as a common flavonol glycoside, exists abundantly in many plants and exhibits various nutritional and pharmacological function. Current study focused on the dose-effect relationship of rutin on the anti-inflammatory and antioxidant activities in vitro against LPS-stimulated RAW 264.7 cells and free radicals or ferric-ion. This study evaluated the anti-inflammatory activity by observation cell morphological and determination of the content of NO, TNF-α, IL-1β and IL-6, and the phagocytic activity in LPS induced RAW 264.7 cells; and revealed the antioxidant activities via assay of DPPH radical scavenging capacity, ABTS radical scavenging capacity, and reducing power. The study indicated that 5, 10, 20, 50 and 100 μM of rutin all exhibited a better anti-inflammatory activity, in especial 50 and 100 μM. Meanwhile, it exerted a stronger antioxidant activities than BHT, and equivalent to VC at the same concentration. Combined, the results suggested that rutin will be a potential and important adjuvant in treatment of inflammatory diseases and oxidative stress.

8

Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions

88%

Reiter R. J., Tan D.-x., Pilar Terron M., Flores L. J., Czarnocki Z.

Acta Biochimica Polonica

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2007

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vol. 54

|

issue 1

1-9

EN

This review summarizes some of the recent findings concerning the long-held tenet that the enzyme, N-acetyltransferase, which is involved in the production of N-acetylserotonin, the immediate precursor of melatonin, may in fact not always control the quantity of melatonin generated. New evidence from several different laboratories indicates that hydroxyindole-O-methyltransferase, which O-methylates N-acetylserotonin to melatonin may be rate-limiting in some cases. Also, the review makes the point that melatonin's actions are uncommonly widespread in organs due to the fact that it works via membrane receptors, nuclear receptors/binding sites and receptor-independent mechanisms, i.e., the direct scavenging of free radicals. Finally, the review briefly summarizes the actions of melatonin and its metabolites in the detoxification of oxygen and nitrogen-based free radicals and related non-radical products. Via these multiple processes, melatonin is capable of influencing the metabolism of every cell in the organism.

9

Nutritional Composition, Minerals, Vitamin C and Antioxidant Analysis of Yellow Mombin (Spondias mombin L.) Nut

88%

Odokwo E. O., Uzoekwe N. M.

World News of Natural Sciences

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2024

|

vol. 53

86-93

EN

The nutritional, mineral, Vitamin C and antioxidant capacity profiling of the nut of Spondias mombin has been carried out. The nut of S. mombin (NSM) was extracted from its fruit and then profiled quantitatively for its nutritional, mineral and vitamin C contents using the AOAC standard procedures. The antioxidant capacity of the methanol extract of NSM was carried out using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay and ferric reducing antioxidant potential (FRAP) techniques. The nut was found to have nutritional facts of: moisture content (12.24±0.06%), lipid content (1.69±0.01%), fibre content (45.27±0.32%), protein content (5.69±0.04%), ash content (0.41±0.02%) and carbohydrate content (34.70±0.33%). The mineral content in mg/g of sample was found to contain: K (7.014), Na (2.966), Ca (1.333), Mg (0.690), Fe (0.131), Cu (0.079), Zn (0.015), Cd (0.004) and Cr (0.009). Pb was not detected. The vitamin C content was 3.89 mg, DPPH antioxidant potential increases as concentration of NSM increases from 25.00 µg/ml to 400 µg/mL and FRAP was observed at 400 μg/ml NSM to be 75.304±0.002 mgAAE. The nut of S. mombin has shown to be good sources for alternative nutrition and as a base for minerals rich in cellular ions. The nut of S. mombin has exhibited antioxidant capacity which can be attributed to the presence of some vital phytoconstituents.

10

Protective effects of cassia seed ethanol extract against carbon tetrachloride-induced liver injury in mice

88%

Xie Q., Guo F.-F., Zhou W.

Acta Biochimica Polonica

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2012

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vol. 59

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issue 2

265-270

EN

Oxidative stress has been recognized as a critical pathogenetic mechanism for the initiation and the progression of hepatic injury in a variety of liver disorders. Antioxidants, including many natural compounds or extracts, have been used to cope with liver disorders. The present study was designed to investigate the hepatoprotective effects of cassia seed ethanol extract (CSE) in carbon tetrachloride (CCl4)-induced liver injury in mice. The animals were pre-treated with different doses of CSE (0.5, 1.0, 2.0 g/kg body weight) or distilled water for 5 days, then were injected intraperitoneally with CCl4 (0.1% in corn oil, v/v, 20 ml/kg body weight), and sacrificed at 16 hours after CCl4 exposure. The serum aminotransferase activities, histopathological changes, hepatic and mitochondrial antioxidant indexes, and cytochrome P450 2E1 (CYP2E1) activities were examined. Consistent with previous studies, acute CCl4 administration caused great lesion to the liver, shown by the elevation of the serum aminotransferase activities, mitochondria membrane permeability transition (MPT), and the ballooning degeneration of hepatocytes. However, these adverse effects were all significantly inhibited by CSE pretreatment. CCl4-induced decrease of the CYP2E1 activity was dose-dependently inhibited by CSE pretreatment. Furthermore, CSE dramatically decreased the hepatic and mitochondrial malondialdehyde (MDA) levels, increased the hepatic and mitochondrial glutathione (GSH) levels, and restored the activities of superoxide dismutase (SOD), glutathione reductase (GR), and glutathione S-transferase (GST). These results suggested that CSE could protect mice against CCl4-induced liver injury via enhancement of the antioxidant capacity.

11

Antioxidant properties of fruits of raspberry and blackberry grown in central Europe

88%

Kostecka-Gugała A., Ledwożyw-Smoleń I., Augustynowicz J., Wyżgolik G., Kruczek M., Kaszycki P.

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issue 1

EN

Fruits of several, mainly Polish cultivars of floricane- and primocane-fruiting red raspberry (Rubus idaeus), black raspberry (Rubus occidentalis) and blackberry (Rubus fruticosus), grown in central Europe during two successive vegetation periods, were investigated. The content of phenolic compounds, including anthocyanins, as well as antioxidant properties of fruit extracts were analysed. A number of methods were employed: ferric ion reducing antioxidant power (FRAP), cupric ion reducing antioxidant capacity (CUPRAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity involving both colorimetric and EPR spectrometric measurements. From among all the tested fruits black raspberries had the largest antioxidant capacity as verified by all methods used in this study. These berries were also the most abundant in phenolic and anthocyanin compounds. Blackberries were characterised by larger antioxidant capacity than red raspberry fruits which were accompanied by higher content of total phenolics and anthocyanins. Berries of primocane-fruiting cultivars, often used for intensive agricultural production, generally did not differ in the total phenolic and anthocyanin content as well as in the antioxidant capacity as compared to the traditional, floricane-fruiting ones. The research contributes to deep characterisation of central European berry fruits which due to their high content and large diversity of health-beneficial compounds are classified as natural functional food.

12

Isolation and antioxidant activity of flavonoids from Holarrhena floribunda (G.don) leaves

88%

Badmus J., Ekpo O., Rautenbach F., Marnewick J., Hussein A., Hiss D.

Acta Biochimica Polonica

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2016

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vol. 63

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issue 2

353-358

EN

Bioactive polyphenolics are ubiquitously present in plants and may play an important role in the prevention and management of certain human diseases. Three known flavonoids viz Kaemperol-3-O-rutinoside (1), quercetin-3-O-glucoside (2) and kaemperol-3-O-glucoside (3) and inseparable mixture (1:1) of quercetin-3-O-glucose/galactose (4) were isolated, and identified for the first time from Holarrhena floribunda. The antioxidant capacity using the ORAC, FRAP and TEAC assays and inhibition of lipid peroxidation were measured for isolated flavonoids. The result showed that compounds 2 and 4 showed significantly increased ORAC, TEAC, and FRAP activities with low pro-oxidant potential as well as improved lipid peroxidation inhibition levels when compared to compounds 1 and 3. The most active compounds were found to be flavonoids with a quercetin basic structure. These results imply that the isolated flavonoid glycosides are responsible for the antioxidant activity of the plant leaves and it forms the scientific basis for its traditional usage.

13

In silico screening, synthesis, in vitro evaluations antibacterial and DPPH scavenging activity of some 1,3,5-trisubstituted 2-pyrazoline derivatives as dihydrofolate reductase inhibitors

88%

Suriya S., Mala V.

|

2018

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vol. 18

|

issue 2

180-186

EN

In this work, synthesis of three pyrazoline derivatives (6-8) is described. (E)-1,3-(phenylsubstituted)-prop-2-en-1-one (3-5) is prepared by the reaction of substituted benzaldehyde with 4-methylacetophenone, whereas condensation cyclization of the same chalcones (3-5) with phenylhydrazine hydrate in ethanol yielded 6-8. The structures of the title compounds (6-8) were characterized by chemical reactions, elemental analysis, and spectral methods such as IR spectra. The synthesized chalcone and pyrazolines were evaluated for in-vitro antibacterial and antioxidant activities against standard. The zone of inhibition for some of the newly synthesized compounds showed notable antibacterial activity against selected bacterial strains when compared with ampicillin. Significant antioxidant activities were also shown by chalcone and pyrazolines.

14

Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects

88%

Serrano J., Cipak A., Boada J., Gonzalo H., Cacabelos D., Cassanye A., Pamplona R., Zarkovic N., Portero-Otin M.

Acta Biochimica Polonica

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2010

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vol. 57

|

issue 2

193-198

EN

A previous report from our group had shown in vitro a direct interaction between peroxidases and dietary antioxidants at physiological concentrations, where in the absence of H2O2, the antioxidants could serve as oxidizing substrates for the peroxidases. However, the physiological relevance of those findings had not been evaluated. The main objective of this study was to determine whether the oxidizing products produced in the interaction between peroxidase and gallic acid at a physiological concentration of 1 µM may promote cell death or survival in a human microvascular endothelial cell line (HMEC-1). Our findings suggested that gallic acid may show a double-edged sword behaviour, since in the absence of H2O2 it may have a pro-oxidant effect which may promote cell injury (evidenced by LDH, Crystal Violet and calcein AM viability/citotoxicity assays), while in the presence of H2O2, gallic acid may act as an antioxidant inhibiting oxidative species produced in the peroxidase cycle of peroxidases. These observations were confirmed with several oxidative stress biomarkers and the evaluation of the activation of cell survival pathways like AKT and MAPK/ERK.

15

Determination of antiradical and antioxidant activity: basic principles and new insights

88%

Tirzitis G., Bartosz G.

Acta Biochimica Polonica

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2010

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vol. 57

|

issue 2

139-142

EN

Although the term 'antioxidant' is used very frequently, there are problems with the definition of antioxidants and estimation of antioxidant activity. The distinction between antioxidant and antiradical activities is not always obvious. This minireview discusses critically the principles, advantages and limitations of the most frequently used methods of estimation of antiradical and antioxidant activities.

16

ASSESSMENTS OF ANTIOXIDANT CONTENT AND THE ANTI-CARCINOGENIC EFFECT OF EXTRACTS OF SOLANUM ROSTRATUM DUNAL IN HUMAN CANCER CELLS

88%

Valadez Vega M. d. C., Izquierdo Vega J. A., Villagómez Ibarra J. R., Sánchez Gutiérrez M., Madrigal Santillán E. O., Morales Gonzalez J. A., Bautista Ávila M., García Velasco L.

Acta Poloniae Pharmaceutica - Drug Research

|

2019

|

vol. 76

|

issue 3

493-502

EN

In Mexico, Solanum rostratum has been employed for the treatment of several diseases, including uterine cancer. The aim of this study was to evaluate the antioxidant and anti-carcinogenic activity of extracts of Solanum rostratum Dunal on MDA and SiHa cell lines. The methanolic, ethyl acetate, and hexane extracts of the aerial parts of Solanum rostratum were tested for phenols concentration, antioxidant activity, and anti-carcinogenic effect. The leaves extracts showed the highest content of phenols; however the flower-fruits extracts showed higher scavenging activity. On the other hand, ethyl acetate extracts exhibited the highest anti-carcinogenic effect, while methanolic extracts showed the least effect. The results of this work indicated that Solanum rostratum is a promising source of antioxidants, and the extracts exert a dose-dependent anti-carcinogenic effect on both cell lines.

17

Relative homogeneity of oral bacterial flora in Crohn’s disease compared to ulcerative colitis and its connections with antioxidant defense — preliminary report

88%

Szczeklik K., Owczarek D., Cibor D., Cześnikiewicz-Guzik M., Krzyściak P., Krawczyk A., Mach T., Karczewska E., Krzyściak W.

Folia Medica Cracoviensia

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2019

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vol. 59

|

issue 1

18

Lycopene as a guardian of redox signalling

88%

Palozza P., Catalano A., Simone R., Cittadini A.

Acta Biochimica Polonica

|

2012

|

vol. 59

|

issue 1

21-25

EN

It has been suggested that lycopene, the major carotenoid found in tomato, exhibits health-beneficial effects by virtue of its antioxidant activity. However, recent literature suggests that lycopene can actually "perform" roles independent of such capacity and involving a direct modulation of redox signalling. Reactive oxygen species are known to act as second messengers in the modulation of cellular signalling leading to gene expression changes and pharmacological responses. Lycopene may control redox-sensitive molecular targets, affecting enzyme activities and expressions and modulating the activation of MAPKs and transcription factors, such as NF-κB and AP-1, Nrf2.

19

The use of serine protease from Yarrowia lipolytica yeast in the production of biopeptides from denatured egg white proteins

88%

Pokora M., Zambrowicz A., Zabłocka A., Dąbrowska A., Szołtysik M., Babij K., Eckert E., Trziszka T., Chrzanowska J.

Acta Biochimica Polonica

|

2017

|

vol. 64

|

issue 2

245-253

EN

Deriving non-conventional enzymes from cheaper sources than those used for commercially available enzymes may result in the production of hydrolysates with beneficial features, while drastically reducing the cost of hydrolysis. This is especially significant for enzymatic hydrolysis as a method of protein waste utilization. We have previously described the ability of non-commercial serine protease from Yarrowia lipolytica yeast to produce/release bioactive peptides from egg white protein by-products (EP). The enzymatic hydrolysis of EP was carried out for 24 h using the serine protease at an enzyme: substrate ratio of 1:30 (w/w). The obtained hydrolysate was characterized by protein degradation of 38% and also exhibited an antioxidant and cytokine-inducing activity. The isolation procedure (ultrafiltration and RP-HPLC) of bioactive peptides from the EP hydrolysate provided peptide fractions with significant antioxidant and ACE inhibitory activities. Three homogeneous and three heterogeneous peptide fractions were identified using MALDI-TOF/MS and the Mascot Search Results database. The peptides, mainly derived from ovalbumin, were composed of 2-19 amino-acid residues. We have thus demonstrated a novel ability of serine protease from Y. lipolytica to release biopeptides from an EP by-product.

20

Kinobeon A, purified from cultured safflower cells, is a novel and potent singlet oxygen quencher

75%

Kambayashi Y., Takekoshi S., Nakano M., Shibamori M., Hitomi Y., Ogino K.

Acta Biochimica Polonica

|

2005

|

vol. 52

|

issue 4

903-908

EN

We recently reported that kinobeon A, produced from safflower cells, suppressed the free radical-induced damage of cell and microsomal membranes. In the present study, we investigated whether kinobeon A quenches singlet oxygen, another important active oxygen species. Kinobeon A inhibited the singlet oxygen-induced oxidation of squalene. The second-order rate constant between singlet oxygen and kinobeon A was 1.15 × 1010 M-1s-1 in methanol containing 10% dimethyl sulfoxide at 37°C. Those of α-tocopherol and β-carotene, which are known potent singlet oxygen quenchers, were 4.45 × 108 M-1s-1 and 1.26 × 1010 M-1s-1, respectively. When kinobeon A was incubated with a thermolytic singlet oxygen generator, its concentration decreased. However, this change was extremely small compared to the amount of singlet oxygen formed and the inhibitory effect of kinobeon A on squalene oxidation by singlet oxygen. In conclusion, kinobeon A was a strong singlet oxygen quencher. It reacted chemically with singlet oxygen, but it was physical quenching that was mainly responsible for the elimination of singlet oxygen by kinobeon A. Kinobeon A is expected to have a preventive effect on singlet oxygen-related diseases of the skin or eyes.

Refine search results

Phytoconstitution and Antioxidant Activity of the Ethanolic Extract of an Antimalarial Herbal Mixture

Antioxidant effects of carotenoids in a model pigment-protein complex

Can angiotensin-converting enzyme inhibitors interfere with the free radicals? Measurement of antioxidant capacity using DPPH radical reduction examined by UV-VIS method

Comparison of chemical composition and biological activities of Seseli rigidum fruit essential oils from Serbia

QSAR modeling of antiradical and antioxidant activities of flavonoids using electrotopological state (E-State) atom parameters

Current concepts in pathophysiology and management of hepatocellular carcinoma

Dose-effect relationship on anti-inflammatory activity on LPS induced RAW 264.7 cells and antioxidant activity of rutin in vitro

Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions

Nutritional Composition, Minerals, Vitamin C and Antioxidant Analysis of Yellow Mombin (Spondias mombin L.) Nut

Protective effects of cassia seed ethanol extract against carbon tetrachloride-induced liver injury in mice

Antioxidant properties of fruits of raspberry and blackberry grown in central Europe

Isolation and antioxidant activity of flavonoids from Holarrhena floribunda (G.don) leaves

In silico screening, synthesis, in vitro evaluations antibacterial and DPPH scavenging activity of some 1,3,5-trisubstituted 2-pyrazoline derivatives as dihydrofolate reductase inhibitors

Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects

Determination of antiradical and antioxidant activity: basic principles and new insights

ASSESSMENTS OF ANTIOXIDANT CONTENT AND THE ANTI-CARCINOGENIC EFFECT OF EXTRACTS OF SOLANUM ROSTRATUM DUNAL IN HUMAN CANCER CELLS

Relative homogeneity of oral bacterial flora in Crohn’s disease compared to ulcerative colitis and its connections with antioxidant defense — preliminary report

Lycopene as a guardian of redox signalling

The use of serine protease from Yarrowia lipolytica yeast in the production of biopeptides from denatured egg white proteins

Kinobeon A, purified from cultured safflower cells, is a novel and potent singlet oxygen quencher