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INFLUENCE OF CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROTECTIVE PROPERTIES OF GELS WITH CHITOSAN FOR THE OESOPHAGEAL MUCOSA

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Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2022
|
vol. 27
183-193
EN
Gastro-oesophageal reflux disease is a serious social problem that affects every sphere of life. The quality of life of people with this disease is reduced due to the presence of troublesome symptoms, which translates into reduced work efficiency and vitality. The major problem is acidic gastro-oesophageal reflux. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and carboxymethylcellulose sodium salt on the protective properties of prepared gels in the treatment of acid reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. Preparations containing 0.3% carboxymethylcellulose sodium salt showed the highest pH. The texture tests showed the effect of carboxymethylcellulose sodium salt concentration on the adhesion work of the tested gels. These gels could be used in the treatment of advanced acid reflux.
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PHYSICOCHEMICAL PROPERTIES OF GELS WITH CHITOSAN THAT PROTECT THE OESOPHAGEAL MUCOSA

100%
Małolepsza-Jarmołowska K.
Progress on Chemistry and Application of Chitin and its Derivatives
|
2022
|
vol. 27
175-182
EN
The incidence of reflux disease increases with age, regardless of gender. This disease is diagnosed more often in highly developed countries. In addition to acidic reflux, the discharge of alkaline intestinal contents into the oesophagus is a major problem. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and hydroxypropylmethylcellulose on the properties of chitosan-containing gels. Preparations containing 4.0% hydroxypropylmethylcellulose showed the lowest pH. These gels could be used to treat advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of the hydroxypropylmethylcellulose concentration on the adhesion work of the tested gels.
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