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Benzimidazole against intestinal parasitic infections

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Akinola O. O., Adebayo E. D.
World News of Natural Sciences
|
2024
|
vol. 55
231-240
EN
Intestinal parasite infections (IPIs) are still a major hazard to public health worldwide, particularly in nations with subpar sanitary infrastructure. Due to poor hygienic conditions, limited access to sanitation, and a disregard for health education, intestinal parasite infections (IPIs) have continued to occur in developing countries. The two benzimidazole-anthelmintic drugs that are frequently prescribed for Necator Americanus and Ancylostoma Duodenale infections are mebendazole and albendazole. These drugs stop the microtubule polymerization that kills mature worms in invertebrates. Necator Americanus and Ancylostoma Duodenale are similarly vulnerable to benzimidazoles. With a high overall cure rate, hookworm infection can be successfully treated. Despite the lack of rigorous safety trials in children under the age of two, methendazole and albendazole have been used frequently in mass drug administration (MDA) programs to treat entire communities, regardless of the age of the participants. The life cycle and route of transmission of intestinal parasites are similar. The most common method for identifying IPIs is the stool test. Several anti-parasitic medications are used as a kind of treatment. However, effective IPI control depends on taking the right preventive actions.
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