Search results

1

Sex-related differences in patients undergoing radiofrequency ablation of atrioventricular nodal reentrant tachycardia

100%

Sokołowska J., Sokołowska M., Adamowicz J., Zyśko D., Radziejewska J., Sławuta A.

European Journal of Translational and Clinical Medicine

|

2019

|

vol. 2

|

issue 2

19-22

EN

Background Atrioventricular nodal reentry tachycardia (AVNRT) is the most common paroxysmal supraventricular tachycardia. The relatively ineffective antiarrhythmic drugs and the predominant young age makes the catheter ablation the therapy of choice in many patients. This results in predominance of this arrhythmia in electrophysiological labs. The aim of the study was to analyze the gender-related differences among patients undergoing the radiofrequency catheter ablation of slow pathway entrance to the atrioventricular node. Material and methods The study group comprised of 147 consecutive patients with diagnosed atrioventricular nodal reentry tachycardia, who underwent the radiofrequency catheter ablation (RFCA) of slow pathway. Patients have been divided into 2 groups, based on sex. Results The overall 97.3% of effectiveness of RFCA was observed. Women were significantly younger than men (53.7+/-17.2 vs 57.7+/-9.8 years) with lower radiation dose (2383.5+/-1993.2 vs 2891.6+/-2377.1 cGyxcm2). Conclusions Younger age of women in comparison to men during RFCA of AVNRT reflects earlier onset of symptoms in women. Gender does not affect the time of fluoroscopy, but the higher rate of inducible tachycardia after RFCA in women may suggest the existence of anatomical difficulties or the operator’s apprehensions. Sex-related difference in radiation dose that we have observed may result from the greater volume of the men’s chest

2

Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?

100%

Rozwadowska K., Daniłowicz-Szymanowicz L., Fijałkowski M., Sikorska K., Szymanowicz W., Lewicka E. K., Raczak G.

|

issue 1

20-25

EN

Background Hereditary haemochromatosis (HH) is an inherited disease in which gene mutation leads to excessive iron absorption and accumulation in different organs, including the heart, which causes damage. Whether the age of patients with HH at the moment of their first diagnosis has an additional effect on the standard echocardiographic parameters was the aim of the study. Material and methods We prospectively enrolled 20 HH patients, and 20 healthy age- and sex-matched volunteers. Analysis of standard echocardiographic parameters was performed and compared in subgroups of ≥50 and <50 years old (yo). Results Comparing HH patients with healthy volunteers in ≥50 yo subgroup, significant differences were found in parameters regarding diastolic function (IVS thickness, LVM index, Em, E/Em, PV S/D, LAA index and LAV index). In the <50 yo subgroup we did not find the abovementioned differences, however LVEF appeared to be lower in the HH patients. Conclusions Despite the lack of clinical symptoms of cardiovascular disease and the lack of deviations in the standard echocardiographic examination, there were a number of differences regarding LV diastolic function parameters in HH patients ≥50 yo, whereas differences regarding LV systolic function were more prominent in HH patients <50 yo when compared with healthy subjects.

3

Sex-related differences in patients undergoing radiofrequency ablation of atrioventricular nodal reentrant tachycardia

100%

Sokołowska J., Sokołowska M., Adamowicz J., Zyśko D., Radziejewska J., Sławuta A.

|

2020

|

vol. 2

|

issue 2

19-22

EN

Background: Atrioventricular nodal reentry tachycardia (AVNRT) is the most common paroxysmal supraventricular tachycardia. The relatively ineffective antiarrhythmic drugs and the predominant young age makes the catheter ablation the therapy of choice in many patients. This results in predominance of this arrhythmia in electrophysiological labs. The aim of the study was to analyze the gender-related differences among patients undergoing the radiofrequency catheter ablation of slow pathway entrance to the atrioventricular node. Material and methods: The study group comprised of 147 consecutive patients with diagnosed atrioventricular nodal reentry tachycardia, who underwent the radiofrequency catheter ablation (RFCA) of slow pathway. Patients have been divided into 2 groups, based on sex. Results: The overall 97.3% of effectiveness of RFCA was observed. Women were significantly younger than men (53.7+/-17.2 vs 57.7+/-9.8 years) with lower radiation dose (2383.5+/-1993.2 vs 2891.6+/-2377.1 cGyxcm2). Conclusions: Younger age of women in comparison to men during RFCA of AVNRT reflects earlier onset of symptoms in women. Gender does not affect the time of fluoroscopy, but the higher rate of inducible tachycardia after RFCA in women may suggest the existence of anatomical difficulties or the operator’s apprehensions. Sex-related difference in radiation dose that we have observed may result from the greater volume of the men’s chest.

4

Age-Related Differences of Hamstring Flexibility in Male Soccer Players

100%

Nikolaïdis P.

Baltic Journal of Health and Physical Activity

|

2012

|

vol. 4

|

issue 2

110-115

EN

Background: The aim of this study was to examine the relationship between age and hamstring flexibility of male soccer players and to provide reference data.Material/Methods: The study comprised 698 male subjects. The largest group consisted of male adolescents (n = 597; aged 10-22 years, yrs), further subdivided into six two-year age groups; the other two groups being children (n = 21, younger than 10 yrs) and adult players (n = 80; older than 22 yrs). All of those who participated in our study were members of competitive soccer clubs. They were examined for anthropometric characteristics, body composition, and performed the sit-and-reach test (SAR).Results: An analysis of variance revealed significant differences between age groups with respect to SAR (F7,690 = 17.62, p<0.001, η2 = 0.15). Our findings indicated that the older the age group, the higher the SAR (e.g. 16.6±5.1 cm in the children's group, 20.7±7.5 cm in the under-16-yr-old group and 24.7±6.9 cm in the adult group). This result came in agreement with the significant and moderate correlation coefficient between age and SAR (r = 0.33, p < 0.001).Conclusions: Although the cross-sectional design did not allow inferring a causal relationship between age and hamstring flexibility, it is reasonable to suppose that there are small gains in flexibility with development. Compared with previous findings, soccer players had similar values to the general population.

5

Age dependence of thermal imaging analysis of body surface temperature in women after cryostimulation

100%

Dębiec-Bąk A., Gruszka K., Sobiech K. A., Skrzek A.

Human Movement

|

2013

|

vol. 14

|

issue 4

299-304

EN

Purpose. The aim of the study was to analyse changes in body surface temperature after a cryostimulation session in women of two different age groups. Methods. The study included 21 female university students aged 21 ± 1.8 years and 15 middle-aged women aged 57.8 ± 3.6 years. All participants were subjected to the effects of extreme low temperature in a cryogenic chamber at -120˚C for 3 min. Body surface temperature measures were taken before and immediately after treatment by a thermal imaging camera. Qualitative and quantitative analysis of the captured thermographic images was performed for 12 anterior and posterior body areas in the standing position. Results. Differences in body surface temperature were found between both age groups prior to the cryostimulation treatment. Temperatures ranged from 29.55° C to 33.49° C in the younger group and 30.45° C and 32.70° C in the older group for the same body areas. Lower temperatures were observed in the older subject group for all analysed areas. After cryostimulation, greater body cooling was observed in the younger group particularly in the lower limbs. The greatest temperature reduction in both groups was observed in the lower limbs, dropping a maximum of 6.31° C, whereas the lowest variation in temperature was observed in the shoulder area by approximately 2° C. Conclusions. The results of the study showed varied distribution of body surface temperature in both age groups. Lower temperatures of the trunk and shoulders were observed in older women compared with the younger women. Greater body cooling following cryostimulation was observed in the group of younger women particularly in the area of the lower limbs.

6

Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?

100%

Rozwadowska K., Daniłowicz-Szymanowicz L., Fijałkowski M., Sikorska K., Szymanowicz W., Lewicka E. K., Raczak G.

European Journal of Translational and Clinical Medicine

|

2018

|

vol. 1

|

issue 1

20-25

EN

Background: Hereditary haemochromatosis (HH) is an inherited disease in which gene mutation leads to excessive iron absorption and accumulation in different organs, including the heart, which causes damage. Whether the age of patients with HH at the moment of their first diagnosis has an additional effect on the standard echocardiographic parameters was the aim of the study. Material and methods: We prospectively enrolled 20 HH patients, and 20 healthy age- and sex-matched volunteers. Analysis of standard echocardiographic parameters was performed and compared in subgroups of ≥50 and <50 years old (yo). Results: Comparing HH patients with healthy volunteers in ≥50 yo subgroup, significant differences were found in parameters regarding diastolic function (IVS thickness, LVM index, Em, E/Em, PV S/D, LAA index and LAV index). In the <50 yo subgroup we did not find the abovementioned differences, however LVEF appeared to be lower in the HH patients. Conclusions: Despite the lack of clinical symptoms of cardiovascular disease and the lack of deviations in the standard echocardiographic examination, there were a number of differences regarding LV diastolic function parameters in HH patients ≥50 yo, whereas differences regarding LV systolic function were more prominent in HH patients <50 yo when compared with healthy subjects.

7

The Influence of Age and Gender on the Value Orientation of Extreme Sports Participants

100%

Pólus-Thiry É., Rédei C.

Physical Culture and Sport. Studies and Research

|

2012

|

vol. 56

|

issue 1

51-58

EN

Research has shown that the popularity of extreme sports is on the rise in Hungary just as in developed countries. While we cannot question the influence of the press, it is very likely that shifts and changes in the value orientation of a society also play an important role in fostering the process. In the first stage of the present study, the value orientation of a group of Hungarian people involved in action sports is mapped where the values are arranged into a latent structure using principal component analysis. In the second stage of research, it is checked whether the examined group is a homogenous community regarding their value orientations, and researchers examine if two variables - age and gender - significantly influence the value orientations of the respondents. Our conclusion is that there is little difference between group members regarding their high preferences for community values and the low preferences for traditional values, but age and gender significantly influence respondents’ attitudes to post-materialist values and partially those to materialist values. Younger participants report higher preferences for both materialist and postmaterialist values, while females attribute higher importance to post-materialist values.

8

Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats

88%

Iciek M., Chwatko G., Lorenc-Koci E., Bald E., Włodek L.

Acta Biochimica Polonica

|

2004

|

vol. 51

|

issue 3

815-824

EN

The redox status of plasma thiols can be a diagnostic indicator of different pathological states. The aim of this study was to identify the age dependent changes in the plasma levels of total, free and protein bound glutathione, cysteine and homocysteine. The determination was conducted in plasma of three groups of rats: 1) young (3-month-old), 2) middle aged (19-month-old), and 3) old (31-month-old). Total levels of glutathione, cysteine and homocysteine and their respective free and protein-bound fractions decreased with age. The only exception was a rise in free homocysteine concentration in the middle group, which indicates a different pattern of transformations of this thiol in plasma. The drop in the level of protein-bound thiols suggests that the antioxidant capacity of plasma diminishes with age, which, consequently, leads to impaired protection of -SH groups through irreversible oxidation. The plasma sulfane sulfur level also declines with age, which means that aging is accompanied by inhibition of anaerobic sulfur metabolism.

9

Hemifacial asymmetries in age perception: the left cheek looks older for females, but not males

88%

Lindell A. K., Cianchetta R. O., Azim S. M., Freeman C. G., de Oliveira N. C., Saban S., Messina J. L., Wilson K. E., Egan A., Caspar M. D., Grey E. J., McDonald B. A., Croxford K. N., Bui T. T., Aiello A. A., Heywood-Smith V. M., Kidd A. J., Stanley S. C., Wakeling A., Hoggan S. A. L., Morriss A. S., Trinh T. P. M., Thai-Nguyen H., Fonte M., Agolli F.

|

vol. 17(4)

417-426

EN

The left hemiface expresses emotion more intensely than the right. Because emotional expressions contract the facial muscles and wrinkle the skin, theoretically the left hemiface’s greater expressivity should prompt more pronounced expression lines and wrinkles on the left than right side of the face. As wrinkles are the most salient age cue, we investigated whether the left hemiface consequently appears older than the right. Two hundred and sixty participants (F=148; M=112) viewed booklets containing pairs of left-left and right-right chimeric faces of eight models (M=F). For each trial participants were asked to make a two alternative forced choice response indicating which image looked older. Results confirmed a left cheek bias, with participants more likely to select left-left than right-right chimeras. Whilst participant gender did not influence perceptions, model gender predicted cheek selections: responses to female models drive the overall left cheek bias. The left cheek (56.8%) appeared older than the right cheek (43.2%) for female models, whereas there was little difference in perceived age between male models' left (50.8%) and right (49.2%) cheeks. Given that youth influences perceptions of female beauty, these findings complement previous research and offer a potential explanation for why the left side of females’ faces are judged less attractive: the right cheek appears younger.

10

Establishment of feline in-house reference intervals for hematologic and biochemical parameters and potential age-related differences

88%

Lin T. L., Chung S. H., Sung C. H., Yeh S. Y., Cheng T. L., Chou C. C., Lin T. L., Chung S. H., Sung C. H., Yeh S. Y., Cheng T. L., Chou C. C.

Polish Journal of Veterinary Sciences

|

2019

|

issue 3

11

Nature of the interactions between work and family satisfaction in women

88%

Markiewicz K., Gaś Z. B.

Acta Neuropsychologica

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2020

|

vol. 18(1)

29-44

EN

The aim of the present study was to specify the nature of the relationships between work and marital satisfaction in the women. In addition it aimed at revealing as to whether demographic variables, such as age, position, length of service, marriage duration, and the number of children have an impact upon the work and marital satisfaction in working women. The present study included 120 married, working women, and analyses the relationship between job satisfaction and marital satisfaction, taking into consideration emotional and cognitive factors. The participants were mostly office workers, of whom 20 (8%) occupied management positions. The Descriptions Inventory, Job Affect Scale, Questionnaire of Well-matched Marriage, and a scale of work-job interactions were administered. Significant positive correlations across almost all variables of job and marital satisfaction were observed. This means that the increase of marital satisfaction corresponds with the increase in job satisfaction, although the work/family conflict resulted in experiencing negative emotions at work. Moreover, the level of job satisfaction was higher than the level of family satisfaction. It was also found that the age and time spent at work proved to have a negative impact upon job satisfaction. Work-family facilitation proved to be crucial since its exclusion made the interface between all factors of family satisfaction and work insignificant. At the same time, the managerial women suffered from work/family conflict to a greater degree than did office workers. The study revealed also that the needs of older workers should be taken into account to maintain their work/life balance.

12

Reliability of Handgrip Strength Test in Basketball Players

88%

Gerodimos V.

Journal of Human Kinetics

|

2012

|

vol. 31

25-36

EN

Handgrip strength is important in basketball as various movements rely on the continuous use of wrist and digits flexor muscles when catching, holding, shooting and throwing the ball. Therefore, the assessment of handgrip strength is used in prepubertal, adolescent and adult basketball players. The reliability of handgrip strength may be influenced by several factors including age. The purpose of this study was to examine the reliability of handgrip strength in basketball players from childhood to adulthood. Male basketball players (n = 90) were assigned into three groups: prepubertal (9.8 ± 0.7yrs), adolescents (14.4 ± 0.6yrs), and adults (26.1 ± 5.6yrs). Each participant performed three maximal isometric contractions on each hand in two occasions, one day apart. Intraclass correlation coefficient (ICC), standard error of measurement (SEM) and 95% limits of agreement (LOA) were calculated. The test-retest reliability was high for both preferred (ICC = 0.94 - 0.98) and non-preferred (ICC = 0.96 - 0.98) hands, without differences in reliability among age-groups. The results showed a significant age-related increase (p < 0.05) in absolute and relative handgrip strength irrespective of hand preference. The present results indicate that maximum handgrip strength can be measured reliably, using the Jamar hand dynamometer, in basketball players from childhood to adulthood.

13

Age and growth rate of Pseudochaenichthys georgianus Norman, 1937 (family Chaenichthyidae) of the South Georgia region

88%

Chojnacki J., Palczewski P., Chojnacki J., Palczewski P.

Polish Polar Research

|

1981

|

vol. 2

|

issue 3-4

14

Quality of life and physical activity of kindergarden teachers

75%

Brodáni J., Žišková I.

Physical Activity Review

|

2015

|

vol. 3

11-21

EN

The contribution presents the relationship between the frequency of physical activity during the week and fields of life quality of kindergarden teachers in three mature parts. In the research took part kindergarden teachers from Slovakia (n = 211) who were divided into groups according to their ontogenesis. The life quality was observed with a modified questionnaire SQUALA and the physical activity level frequency during the week. The data is presented by descriptive characteristics (n, M, SD) and statistic importance of differences, let us say relationships which are measured by non-parametric methods (W, U, rs), by the importance level (p<0.05; p<0.10). The results showed the most numerous correlations between the physical activity during the week and fields of life quality of teachers in age group from 36-46 years (middle mature) who do the physical activity M: 3.250 during the week by SD: 2.761. In this group were proved positive correlations with the field of physical well-being (p<0.01), psychosocial well-being (p<0.01), material well-being (p<0.01), education (p<0.10), free time (p<0.05), appearance and property of things (p<0.01). Specially this age is characteristic by reaching the highest goals of physical and mental performance. In the groups of younger and older mature we do not find so many important relationships between the physical activity and some fields of life quality. In these groups we did not find any important correlations of physical activity with physical well-being where the group of young mature reached the same level of physical activity as the group of middle mature. The conclusions show the importance of physical activity in life of kindergarden teachers, they show some possibilities of influencing the life quality through the physical activities but also creating the optimal conditions possibilities to increase the life quality in social environment. The contribution is part of the Ministry of Education grant KEGA 014UKF-4/2013 Improving the quality and level of health of adolescents by means of physical activity in primary and secondary schools.

15

Selected determinants of the frequency of consuming particular food product groups among regional-level football referees

75%

Gacek M., Kosiba G., Wojtowicz A.

Central European Journal of Sport Sciences and Medicine

|

2020

|

vol. 32

|

issue 4

5-14

EN

The aim of the study was to assess the frequency of consuming particular food groups among regional-level football referees depending on age, refereeing experience and sense of generalised self-efficacy. The study was conducted among agroup of 138 male football referees from the Małopolska and Podkarpacie regions, using the authors’ own questionnaire on food consumption frequency and the Generalised Self-Efficacy Scale (GSES). It was shown that along with the age of the referees, the frequency of consuming fruit (p < 0.001), milk and dairy products with reduced fat content (p < 0.001), poultry and cold-cuts (p < 0.01) as well as nuts (p < 0.001) increased, while the frequency of consuming white cereal products (p < 0.001) and sea fish (p < 0.05) decreased. Along with refereeing experience, the frequency of eating fruit (p < 0.001), milk and dairy products with reduced fat content (p < 0.01), poultry meat and cold-cuts (p = 0.001), nuts (p < 0.001) and alcoholic beverages (p < 0.001) increased, while the frequency of consuming white cereal products (p < 0.001), sea fish (p < 0.05) and sweet carbonated drinks (p < 0.01) decreased. Apositive correlation was found between the intensity of generalised self-efficacy and the frequency of consuming milk and dairy products with reduced fat content (p < 0.01), fermented dairy products (p < 0.01), eggs (p < 0.001) and mineral water (p < 0.001) as well as dry red wine (p < 0.05), and anegative correlation was noted with the frequency of consuming pork (p < 0.05), fast food products (p = 0.001) and sweetened carbonated beverages (p < 0.001). In the examined group of regional-level football referees, there was atendency towards more rational nutrition choices along with age and refereeing experience as well as asense of self-efficacy, while the most explicit trends regarded relationships with the sense of self-efficacy.

16

Self-Determination and Goal Orientation in Track and Field

75%

Chin N.-S., Khoo S., Low W.-Y.

Journal of Human Kinetics

|

2012

|

vol. 33

151-161

EN

This study investigated gender, age group and locality differences in adolescent athletes' self-determination motivation and goal orientations in track and field. It also examined the relationship between the self-determination theory and achievement goal theory. A total of 632 (349 boys, 283 girls) adolescent athletes (aged 13-18 years) completed the Sports Motivation Scale and Task and Ego Orientation in Sport Questionnaire. Results indicated significant differences between gender on intrinsic motivation, extrinsic motivation, amotivation (t(630) = 4.10, p < 0.05) and ego orientation (t(630) = 2.48, p < 0.05). Male students reported higher intrinsic motivation, extrinsic motivation, amotivation and ego orientation. A significant difference was found between age groups on task orientation (t(630) = 1.94, p < 0.05) and locality on ego orientation (t(630) = 1.94, p < 0.05). Older athletes showed significantly higher task orientation. Rural athletes had higher ego orientation whereas urban athletes have higher intrinsic motivation. Task orientation was related to intrinsic motivation (r = 0.55, p < 0.01), extrinsic motivation (r = 0.55, p < 0.01), but weakly related to amotivation (r = 0.10, p < 0.01). Ego orientation was related to intrinsic motivation (r = 0.30, p < 0.01), extrinsic motivation (r = 0.36, p < 0.01) and amotivaion (r = 0.36, p < 0.01). Task orientation was related to ego orientation (r = 0.29, p < 0.01). Multiple regression analysis showed intrinsic motivation, extrinsic motivation and amotivation accounted for 30.5% of the variances in task orientation.

17

WIEK A POZIOM AKCEPTACJI CHOROBY PRZEZ PACJENTÓW Z WIRUSOWYM ZAPALENIEM WĄTROBY TYPU C

75%

Kaźmierczak J., Kochman D.

Long-Term Care Nursing

|

2019

|

vol. 4

|

issue 1

25-33

EN

Introduction Most cases of hepatitis C affect patients between 20 and 40 years of age. This disease is a major diagnostic challenge due to the its insidious course. Aim The aim of this study is to analyse the quality of life of patients with hepatitis C, conditioned by the patient’s age. Material and methods The research was conducted among 101 people. The study used the estimation method and the diagnostic survey, the survey technique, while the tools used in the work are a standardized WHOQOL-Bref question¬naire. Results The age of the respondents did not remain in a statistically significant correlation with the results of quality of life and its subscales (p> 0.05). Conclusions The advanced age had impact on the lower level of quality of life of Hepatitis C patients

PL

Wstęp Najwięcej zachorowań na wirusowe zapalenie wątroby typu C dotyczy pacjentów między 20 a 40 rokiem życia. Choroba ta jest dużym wyzwaniem diagnostycznym ze względu na skąpoobjawowy przebieg. Cel Celem niniejszego opracowania jest analiza jakości życia pacjentów z WZW typu C uwarunkowana wie-kiem chorego. Materiał i metody Badania zostały przeprowadzone wśród 101 osób. Zastosowano w nich metodę szacowania oraz sondażu diagnostycznego, technikę ankietowania, natomiast narzędzia użyte w pracy to standaryzowany kwestiona¬riusz WHOQOL-Bref. Wyniki Wiek badanych nie pozostawał w istotnej statystycznie korelacji z wynikami jakości życia i jej podskal (p>0,05). Wnioski Zaawansowanie wieku pacjentów z WZW typu C wpływało na osiągnięcie niższego poziomu jakości życia.

18

Energy budget changes in response to desiccation stress in Tribolium castaneum (Coleoptera: Tenebrionidae)

75%

Bigham M., Ahsaei S. M., Hosseininaveh V., Allahyari H., Bigham M., Ahsaei S. M., Hosseininaveh V., Allahyari H.

|

2019

|

vol. 59

|

issue 1

19

Changes in composition of Notothenia gibberifrons Lonnberg population of the shelf of South Georgia in the years 1977—1979

75%

Skóra K. E., Skóra K. E.

Polish Polar Research

|

1980

|

vol. 1

|

issue 4

20

Polimorfizm -643C/T genu RANKL i jego związek z osteoporozą u kobiet po menopauzie

63%

Boroń D., Plewka A., Jędrusik P.

Annales Academiae Medicae Silesiensis

|

2014

|

vol. 68

|

issue 6

415-423

EN

INTRODUCTION RANKL is a key cytokine involved in osteoclast differentiation from its precursors, activation and survival of osteoclasts themselves. Because RANKL binds with RANK, the presence of RANK on target cells is a necessary condition of target cell control mediated by RANKL. AIM OF STUDY The aim of the study was to examine the incidence of RANKL gene polymorphism and evaluate its association with the clinical parameters concerning bone turnover and the degree of postmenopausal osteoporosis development. MATERIAL AND METHODS The study was conducted among a group of 570 women at postmenopausal age (404) and reproductive age (166). The group at postmenopausal age included women with osteoporosis, osteopenia as well as healthy individuals. The women at reproductive age were healthy. The polymorphism incidence of the examined gene in a group of patients with determined bone mineral density (BMD) and in the control group was studied. The study was performed by means of the RFLP-PCR method. RESULTS The obtained results did not show a correlation of RANKL gene C-643T polymorphism with decreased bone density or increased risk of osteoporotic changes after menopause. CONCLUSIONS The homozygote of the TT polymorphism of the RANKL receptor gene seems to be an increased risk factor of osteoporosis development and is associated with growth and birth mass.

PL

WSTĘP RANKL jest kluczową cytokiną uczestniczącą w różnicowaniu osteoklastu ze swoich prekursorów oraz aktywacji i przeżyciu samych osteoklastów. Ponieważ wiąże się z RANK, obecność RANK na komórkach docelowych jest nieodzownym warunkiem kontroli komórek docelowych za pośrednictwem RANKL. CEL PRACY Celem pracy było zbadanie częstości występowania polimorfizmu genu RANKL oraz ocena jego związku z parametrami klinicznymi dotyczącymi obrotu kostnego i stopnia zaawansowania osteoporozy pomenopauzalnej. MATERIAŁY I METODY Badania przeprowadzono w grupie 570 kobiet w wieku postmenopauzalnym (404 kobiety) i rozrodczym (166 kobiet). Grupa w wieku postmenopauzalnym obejmowała kobiety z osteoporozą, osteopenią i zdrowe. Kobiety w wieku rozrodczym były zdrowe. Zbadano częstość występowania polimorfizmu badanego genu w grupie pacjentek z oznaczoną gęstością mineralną kości (bone mineral density – BMD) oraz w grupie kontrolnej. Badanie przeprowadzono metodą RFLP-PCR. WYNIKI Uzyskane wyniki badań nie wykazały korelacji polimorfizmu C-643T genu RANKL ze zmniejszoną gęstością kości oraz zwiększonym ryzykiem występowania zmian osteoporotycznych po menopauzie. WNIOSKI Wydaje się, że homozygota TT polimorfizmu genu receptora RANKL może być czynnikiem zwiększonego ryzyka wystąpienia osteoporozy i jest powiązana ze wzrostem i masą urodzeniową.

Refine search results

Sex-related differences in patients undergoing radiofrequency ablation of atrioventricular nodal reentrant tachycardia

Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?

Sex-related differences in patients undergoing radiofrequency ablation of atrioventricular nodal reentrant tachycardia

Age-Related Differences of Hamstring Flexibility in Male Soccer Players

Age dependence of thermal imaging analysis of body surface temperature in women after cryostimulation

Does the age of patients with hereditary hemochromatosis at the moment of their first diagnosis have an additional effect on the standard echocardiographic parameters?

The Influence of Age and Gender on the Value Orientation of Extreme Sports Participants

Plasma levels of total, free and protein bound thiols as well as sulfane sulfur in different age groups of rats

Hemifacial asymmetries in age perception: the left cheek looks older for females, but not males

Establishment of feline in-house reference intervals for hematologic and biochemical parameters and potential age-related differences

Nature of the interactions between work and family satisfaction in women

Reliability of Handgrip Strength Test in Basketball Players

Age and growth rate of Pseudochaenichthys georgianus Norman, 1937 (family Chaenichthyidae) of the South Georgia region

Quality of life and physical activity of kindergarden teachers

Selected determinants of the frequency of consuming particular food product groups among regional-level football referees

Self-Determination and Goal Orientation in Track and Field