Search results

Search:
in the keywords: Vaccines

Sort By:

Limit search:

Vaccine as a remedy for antimicrobial resistance; what are the Pros and Cons?

100%

Idris I., Adesola R. O.

World News of Natural Sciences

2022

vol. 42

76-84

Before microorganisms were discovered as the causative agents of diseases, it was taught that diseases occur as a result of an imbalance in energy channels within the body system. With the advent of antimicrobials drugs to cure these diseases in both humans and animals, these antimicrobial drugs turn out to be ineffective as a result of overuse and misuse that lead to antimicrobial resistance. Antimicrobials resistance is a silent pandemic having high morbidity and mortality that result in the death of over 1.2 million people worldwide as of 2019. Antimicrobial drugs are meant to prevent and treat disease but as a result of irrational usage, they pose great risks to humans, animals, and also the environment. This resistance is the major cause of persistent diseases and there is a need to avert its transmission and prevent further occurrence through a multidisciplinary approach, approaches to vaccine design and development, and also strengthening health care services delivery.

Surmounting antimicrobial resistance in the Millennium Superbug: Staphylococcus aureus

86%

Saxena S., Gomber C.

Open Medicine

2010

vol. 5

issue 1

12-29

Staphylococcus aureus is the third most dreaded pathogen posing a severe threat due to its refractory behavior against the current armamentarium of antimicrobial drugs. This is attributed to the evolution of an array of resistance mechanisms responsible for morbidity and mortality globally. Local and international travel has resulted in the movement of drug resistant S. aureus clones from hospitals into communities and further into different geographical areas where they have been responsible for epidemic outbreaks. Thus, there is a dire necessity to refrain further cross movement of these multidrug resistant clones across the globe. The plausible alternative to prevent this situation is by thorough implementation of regulatory aspects of sanitation, formulary usage and development of new therapeutic interventions. Various strategies like exploring novel antibacterial targets, high throughput screening of microbes, combinatorial and synthetic chemistry, combinatorial biosynthesis and vaccine development are being extensively sought to overcome multidrug resistant chronic Staphylococcal infections. The majority of the antibacterial drugs are of microbial origin and are prone to being resisted. Anti-staphylococcal plant natural products that may provide a new alternative to overcome the refractory S.aureus under clinical settings have grossly been unnoticed. The present communication highlights the new chemical entities and therapeutic modalities that are entering the pharmaceutical market or are in the late stages of clinical evaluation to overcome multidrug resistant Staphylococcal infections. The review also explores the possibility of immunity and enzyme-based interventions as new therapeutic modalities and highlights the regulatory concerns on the prescription, usage and formulary development in the developed and developing world to keep the new chemical entities and therapeutic modalities viable to overcome antimicrobial resistance in S. aureus.

Refine search results

1 Open Medicine

1 World News of Natural Sciences

1 2022

1 2010

1 Adesola R. O.

1 Gomber C.

1 Idris I.

1 Saxena S.

Search results

Vaccine as a remedy for antimicrobial resistance; what are the Pros and Cons?

Surmounting antimicrobial resistance in the Millennium Superbug: Staphylococcus aureus