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1

Immune function of the placenta and endothelium in viral infection, nonspecific immunity

100%
Paradowska E.
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vol. 49
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issue 1
137-145
2

Endothelium as target for virus infection

100%
Blach-Olszewska Z., Zaczynska E.
Postępy Higieny i Medycyny Doświadczalnej
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1996
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vol. 50
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issue 3
233-243
EN
The review concerns the susceptibility of human endothelial cells to several viruses, especially CMV and HIV. Viral infections of endothelium in vivo develop usually in immuno-compromissed transplant recipients and in patients with AIDS. Endothelium of noninfected persons presents endogenous, nonspecific immunity against viruses. The constitutive production of cytokines with antiviral activities such as IFN, TNF and IL-6, seems to be responsible for the immunity of endothelium. The consequence of viral infections of endothelium (especially CMV) may be potentiation of allograft rejection and also development of artheriosclerosis. In the article the possible mechanisms and contribution of viruses to the processes are disscussed.
3

Viruses as hijackers of PML nuclear body

100%
Moller A., Schmitz M. L.
Archivum Immunologiae et Therapiae Experimentalis
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2003
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vol. 51
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issue 5
295-300
EN
Promyelocytic leukemia nuclear bodies (PML-NBs) are discrete interchromosomal macromolecular structures. The integrity of this dynamic nuclear subcompartment critically depends on the presence of the name-giving PML protein. Among the permanent or transient residents of PML-NBs are various regulatory proteins, including Sp100, CBP, pRb, HIPK2, RAD51 and p53. PML-NBs are frequently targeted by viral infections, as a number of different RNA and DNA viruses including herpesviruses, adenoviruses, papovaviruses, papillomaviruses and arenaviruses cause changes in PML-NBs. Viruses interfere with PML-NB in two ways: 1) some viral proteins can associate with PML-NB proteins and/or lead to the destruction and lysis of this subnuclear compartment, thus aiding viral gene expression and disabling the host's innate immunity; 2) the parental genomes of some nuclear-replicating DNA viruses associate preferentially with PML-NBs, which presumably serves to assist in viral gene expression or replication. Here we feature the different viral strategies leading to the hijacking of PML-NBs and discuss the consequences for the immune response.
4

Role of the adaptins, dynamin-like GTP-ases and Rab proteins in metabolic disorders and various infections

88%
Kierczak M., Surmacz L., Wiejak J., Wyroba E.
Postępy Higieny i Medycyny Doświadczalnej
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2003
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vol. 57
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issue 6
727-737
EN
Numerous metabolic and genetic diseases are due to mutations in adaptins, dynamin-like GTP-ases or disorders in trafficking machinery mediated by Rab proteins. A great number of pathogenes including viruses (HIV, SIV), bacteria and protozoa use various elements of endocytic/trafficking machinery to get into the host cells and to make their infection successful. Their different strategies are discussed.
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