Search results

1

Treatment of adverse drug reactions in a dermatology department

100%

Ganeva M., Gancheva T., Baldaranov I., Troeva J., Hristakieva E.

Open Medicine

|

2011

|

vol. 6

|

issue 1

37-44

EN

The aim of the study was to evaluate the pattern of utilization of systemic drugs used in the management of adverse drug reactions (ADRs) leading to hospitalization. A prospective pharmacovigilance study was carried out among patients admitted to the Clinic of Dermatology and Venereology in Stara Zagora (July 1999–June 2009). ADRs were classified by type, severity and causality. Casecausality was scored according to Naranjo et al. (1981). Drug utilization was measured in defined daily doses (DDDs) per 100 hospital bed days. A total of 144 cutaneous ADRs, predominantly “type B” were the reason for hospitalization. Highest utilization for the management of ADRs was found for the drug groups “Blood and blood forming organs” (406.08 DDDs/100 bed days) and “Respiratory system” (111.15 DDDs/100 bed days). The use of DDD for measuring drug utilization reveals the importance of drug-induced exacerbations of chronic skin diseases like psoriasis which were associated with significant utilization of drugs belonging to the group “Blood and blood forming organs”. Considering the low preventability of “type B” ADRs, our findings suggest that potential reduction of drug-related hospitalizations may be achieved through the rational use of drugs in patients with comorbidities.

2

Spinal meningiomas: Clinical and therapeutic tonsiderations

100%

Schröder J., Fischer B., Palkovic S., Wassmann H.

Open Medicine

|

2008

|

vol. 3

|

issue 3

322-326

EN

Meningiomas of the spinal canal are rare, in contrast to their cranial counterparts. This study reports on the dominant features of spinal meningiomas before and after treatment. We treated 30 patients (23 female) with meningiomas of the spinal canal from 1992 to 2003. The mean age was 68 (range: 43–91). Upon admission, 26 patients presented with a marked neurological deficit (11 paraparesis, 9 motor weakness, 4 myelopathic ataxia, 1 quadriplegia, and 1 cauda equina syndrome). Two patients had sensory deficits, and two had pain only. The distribution of the tumors was as follows: 8 cases were cranio-cervical, 1 case was cervical, 6 cases were at the cervico-thoracic junction, 9 cases were of the thoracic spine, 5 cases were of the thoracolumbar spine, and 1 case was of the lumbar spine. Five cases also had intracranial manifestations. The mean interval between the onset of the first symptoms and treatment was 12 months. All cases were treated via (hemi)-laminectomy for complete removal of the tumor and occasionally via duraplasty. After a mean follow-up of 3 years, symptoms had improved by 3 points (on a 5-point scale) in 3 cases, by 2 points in 7 cases, and by 1 point in 12 cases; 7 cases were unchanged, and 1 case had worsened by 1 point. We observed 3 local recurrences. One case developed manifestations at a different site. Spinal meningiomas are often diagnosed late, after they have already caused major neurological deficits. Nevertheless, owing to their benign character, the outcome is favorable when treated appropriately. The outcome depends above all on the initial neurological status. The worse the deficit is, the less probable it is that the patient will recover neurologically.

3

Characterization and Valorization of Industrial Wastes (Molecular Sieves) in the Gas Complex of GP1/Z by BET and Surface Charge Method

100%

Belarbi K., Hadjel M.

Acta Physica Polonica A

|

2017

|

vol. 131

|

issue 3

545-547

EN

Industrial waste generates a supplementary cost for companies which must, by the force of law, take in charge their wastes, whether by their own means or through outside services. Molecular sieves used in the sections of dehydratation of natural gas become waste as soon as they are saturated and there is no possibility of regeneration. As a matter of fact, those of type 4Å are used in GP1/Z complex in Algerian company Sonatrach. Within the scope of this work the proposition to valorize these industrial wastes is put forward in the light of a series of analyses and experiments with distilled and polluted water. In this work a path is opened for further research valorization of the type 4Å saturated molecular sieves, used in the gas industry. After a simple wash with distilled water, we have noticed with the naked eye that our sample had changed color from black to white gray. We have repeated the same physical magnetism test, which was positive. We have carried a heat treatment at 100°C to remove physiosorbed water and 350°C heat treatment to remove the pore water. The surface area and pH of point of zero charge (pH_{PZC}) of used zeolite were calculated as 37.54 m² g¯¹ and 6, respectively. The surface area and the pH of point of zero charge(pH_{PZC}) of unused zeolite were calculated as 6.965 m² g¯¹ and 7, respectively.

4

Is Ozone (O3) Treatment Effective in Atrophic Rhinitis? Experimental Animal Study

88%

Altaş B., Koçak H. E., Altınay S., Yücebaş K., Taşkın Ü., Oktay M. F.

Polish Journal of Otolaryngology

|

2018

|

vol. 72

|

issue 5

37-44

EN

Introduction: Atrophic rhinitis (AR) is a disease characterized by atrophy of the mucosa, submucosa, bone tissue due to an unknown cause and excessive nasal cavity enlargement. The disease still has no complete treatment, and the treatment of functional loss of atrophic cells in AR is still a matter to be investigated. Ozone (O3) therapy has been shown to enhance cell metabolism, angiogenesis, fibroblast activity and collagen synthesis. Aim: To determine whether ozone treatment affects the disease histopathologically, in experimentally created AR. Material - Method: Twelve Wistar Hanover strain albino male rats were included in the study. Atrophic rhinitis was induced in animals by administering Pasteurella multocida toxin diluted with saline for 21 days to both nasal cavities. A total of 12 animals included in the study were divided into 2 groups as control and study. Ozone gas (60 μg/mL) was administered rectally to the study group for 21 days. After 2 weeks, the rats were decapitated, the nasal cavities were removed as a block, and atrophic rhinitis parameters (epithelial hyperplasia, goblet cell loss, cilia loss, inflammatory infiltration and vascular ectasia) were evaluated under light microscopy by histopathological examination and statistically interpreted. Result: The incidence of vascular ectasia was significantly lower in the ozone group compared to the control group (p<0.05). There was no significant difference between the groups regarding other histopathologic findings. Conclusion: Ozone treatment was moderate at the histopathological level. We concluded that ozone therapy has no or very limited effect on atrophic rhinitis.

5

Rectal duplication, rare cause of constipation - case report

88%

Marjanovic Z., Djordjevic I., Slavkovic A., Krstic M.

Open Medicine

|

2012

|

vol. 7

|

issue 5

621-623

EN

Digestive tract duplications are uncommon congenital anomalies, encountered mostly in the first 3 months of life. Overall the rectum is the least common site of alimentary duplications. We represent a case of large cystic non-communicating duplication that manifested with constipation and profuse rectal bleeding. When diagnosis was established, surgery was planned and the cyst was enucleated completely. Histopathology examination confirmed the diagnosis.

6

Is Ozone (O3) Treatment Effective in Atrophic Rhinitis? Experimental Animal Study

88%

Altaş B., Koçak H. E., Altınay S., Yücebaş K., Taşkın Ü., Oktay M. F.

Otolaryngologia Polska

|

2018

|

vol. 72(5)

37-44

EN

Introduction: Atrophic rhinitis (AR) is a disease characterized by atrophy of the mucosa, submucosa, bone tissue due to an unknown cause and excessive nasal cavity enlargement. The disease still has no complete treatment, and the treatment of functional loss of atrophic cells in AR is still a matter to be investigated. Ozone (O3) therapy has been shown to enhance cell metabolism, angiogenesis, fibroblast activity and collagen synthesis. Aim: To determine whether ozone treatment affects the disease histopathologically, in experimentally created AR. Material - Method: Twelve Wistar Hanover strain albino male rats were included in the study. Atrophic rhinitis was induced in animals by administering Pasteurella multocida toxin diluted with saline for 21 days to both nasal cavities. A total of 12 animals included in the study were divided into 2 groups as control and study. Ozone gas (60 μg/mL) was administered rectally to the study group for 21 days. After 2 weeks, the rats were decapitated, the nasal cavities were removed as a block, and atrophic rhinitis parameters (epithelial hyperplasia, goblet cell loss, cilia loss, inflammatory infiltration and vascular ectasia) were evaluated under light microscopy by histopathological examination and statistically interpreted. Result: The incidence of vascular ectasia was significantly lower in the ozone group compared to the control group (p<0.05). There was no significant difference between the groups regarding other histopathologic findings. Conclusion: Ozone treatment was moderate at the histopathological level. We concluded that ozone therapy has no or very limited effect on atrophic rhinitis.

7

Recurrence of retroperitoneal fibrosis with pancreatic involvement - the importance of imaging methods

75%

Djerassi R., Krupev M., Nikolova M., Naumov N., Marianovski V., Elenkov C., Postadjian A.

Open Medicine

|

2008

|

vol. 3

|

issue 3

365-369

EN

Retroperitoneal fibrosis (RPF) is a rare disease associated with the development of chronic inflammation and fibrogenesis in the retroperitoneal space. The disease usually manifests with acute or acute over chronic renal failure and/or urosepsis. Pancreatic involvement in RPF is rare but has been described in the literature. The diagnosis of RPF is made mainly by imaging methods. Abdominal echography scan reveals the presence of an obstruction with or without inflammation; computed tomography and magnetic resonance imaging show the type and the spreading of fibrosis. Here, we report a 50-year-old female patient diagnosed with RPF during operative intervention in 2003. Initial treatment with corticosteroids and tamoxifen lead to remission. In 2007, late recurrence was observed, with tumor-like lesions over the upper, posterior, and anterior surfaces of the pancreas, spreading to intraperitoneal structures and more pronounced on the left side. Abdominal echography on day 30 showed that corticosteroid treatment lead to a decrease in the tumor-like lesions.

8

Evidence-based management of pancreatitis

75%

Zambudio N., Muffak K., Villegas T., Becerra A., Fundora Y., Garrote D., Ferrón A.

Open Medicine

|

2014

|

vol. 9

|

issue 4

594-600

9

Personal autonomy in the management of candidal prosthetic joint infection

63%

Villamil-Cajoto I., Eynde-Collado A., Otero L., Villacian Vicedo M.

Open Medicine

|

2012

|

vol. 7

|

issue 4

539-541

EN

The principle of patient autonomy dominates the contemporary debate in medical ethics. Twenty-five years ago, most major medical decisions were left exclusively in the hands of physicians. Such decisions were usually made with beneficent intent but without open discussion, much less the full participation of the patient. Our case involves a patient’s decision to treat an infection with Candida species, the most common fungi affecting humans in a broad spectrum of opportunistic infections, including bones and joints. Only four recent cases of delayed reimplantation arthroplasty for candidal prosthetic joint infection have been reported, and there are no reports, besides ours, of successful non-surgical resolution of candidal prosthetic joint arthritis. We report this case as a patient’s choice with an excellent outcome.

Refine search results

Treatment of adverse drug reactions in a dermatology department

Spinal meningiomas: Clinical and therapeutic tonsiderations

Characterization and Valorization of Industrial Wastes (Molecular Sieves) in the Gas Complex of GP1/Z by BET and Surface Charge Method

Is Ozone (O3) Treatment Effective in Atrophic Rhinitis? Experimental Animal Study

Rectal duplication, rare cause of constipation - case report

Is Ozone (O3) Treatment Effective in Atrophic Rhinitis? Experimental Animal Study

Recurrence of retroperitoneal fibrosis with pancreatic involvement - the importance of imaging methods

Evidence-based management of pancreatitis

Personal autonomy in the management of candidal prosthetic joint infection