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Molecular and cellular basis of interactions

100%
Zastawny T. H., Olinski R.
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vol. 47
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issue 2
101-121
EN
Cis-DDP is an with activity against various . It is generally accepted that is the of cis-DDP. The present paper describes the binding models of cis-DDP to DNA, structural distortion in DNA induced by covalent binding of cis-DDP and repair studies of Pt-DNA adducts in pro- and eucariotic systems. We also discuss the possible mechanisms of acquired of to cis-DDP and analoques, and potential clinical implication of this fenomenon.
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