Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 2

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  TRANSPLANT
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1

Prevalence of human herpesvirus 6 antibodies and DNA in allogeneic stem cell transplant patients: two-year single centre experience

100%
Dzieciatkowski T., Przybylski M., Torosian T., Tomaszewska A., Luczak M.
Archivum Immunologiae et Therapiae Experimentalis
|
2008
|
vol. 56
|
issue 3
201-206
EN
Human herpesvirus 6 (HHV-6) has been recognized as a potentially significant pathogen in hemopoietic stem cell transplant (HSCT) recipients. Different clinical manifestations have been described, including fever, skin rash, bone marrow suppression, and encephalitis. Materials and Methods: A retrospective review of a group of 26 adult recipients of allogeneic HSCTs was conducted. Serum samples taken before transplant were examined for the presence of specific anti-HHV-6 IgM and IgG antibodies. After transplantation, quantitative real-time PCR was used to determine viral load in plasma samples from days 0?180 post-transplant. Results: HHV-6 DNA was detected in plasma samples in 8 (30%) of the 26 recipients between days 18 and 40 after transplantation. All of them developed fever of unknown origin and over 50% had graft-versus-host disease features. Three individuals from this group died during detectable HHV-6 viremia. Another two recipients showed a single positive PCR result at a later time. Infection with HHV-6 was thus confirmed in 10 (38.5%) of the 26 graft recipients. Conclusions: There is a high frequency of detectable HHV-6 viral load in stem cell transplant recipients in Poland. Further investigation to monitor HHV-6 reactivation in graft recipients will be important to improve outcome for these patients.
2

Cartilage formed by syngeneic rat chondrocytes in joint surface defects is rejected in animals sensitized with allogeneic chondrocytes: involvement of the synovial lining

88%
Moskalewski S., Osiecka-Iwan A., Hyc A., Niderla J.
Archivum Immunologiae et Therapiae Experimentalis
|
2005
|
vol. 53
|
issue 2
159-168
EN
The aim of the study was to discover the mechanism of rejection of chondrocyte transplants introduced into articular cartilage defects. Chondrocytes from 3?5-day-old Lewis or WAG rats were liberated by enzymatic digesand tion from articular-epiphyseal cartilage complexes and implanted into defects made in the subpatellar region of the femur condyle of naive Lewis rats. Syngeneic transplants were also done after sensitization of the recipients with allogeneic chondrocytes injected intramuscularly. The transplants and synovial membrane were studied in periodate-lysineparaformaldehyde- fixed material with antibodies against B lymphocytes, CD4+ and CD8+ cells, NK cells, and macrophages. For detection of humoral response, chondrocyte lysates were subjected to protein electrophoresis and Western blotting with sera from the transplant recipients. Cartilage produced in intracartilaginous transplants of syngeneic chondrocytes did not show any signs of rejection. CD8+ lymphocytes and macrophages accumulated in the vicinity of cartilage produced by similar transplants in animals sensitized with intramuscular transplants of allogeneic WAG chondrocytes or bearing transplants of allogeneic WAG chondrocytes. CD8+ cells penetrated into the peripheral part of the cartilage, while macrophages advanced much more deeply. No specific anti-chondrocyte antibody was detected. The synovium from rats bearing intracartilaginous transplants of allogeneic chondrocytes or syngeneic chondrocytes after sensitization contained macrophages and CD8+ cells. The rejection of cartilage formed by syngeneic chondrocyte transplants in sensitized animals argues in favor of a chondrocyte-specific antigen expression. The involvement of the synovial membrane during transplant rejection suggests that it should be included in observations of the behavior of chondrocyte transplants introduced into articular cartilage.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.