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Multilevel regulation of the tyrosine hydroxylase. II. Transcriptional regulation

100%

Lenartowski R., Goc A.

issue 5

671-686

The tyrosine hydroxylase gene is subject to very precise regulation which aim is to adjust the level of the catecholamines to current stimuli disturbing the homeostasis . The fine tuning of the TH gene activity is realized by the ?cross-talk? between the complexes of transcriptional factors with their appropriate regulatory sequences. The transcriptional aspect of that regulation has been reviewed emphasizing the rule of the regulatory sequences in determining cell, tissue and developmental specificity of the TH gene activity.

BH3-only proteins: the lords of death

80%

Fleischer A., Rebollo A., Ayllon V.

Archivum Immunologiae et Therapiae Experimentalis

2003

vol. 51

issue 1

9-17

Although the mechanisms by which Bcl-2 family proteins control the apoptotic machinery of the cell are not fully understood, it becomes clear that the role of BH3-only proteins consists in serving as sensors or sentinels of cellular damage, transducing the apoptotic stimuli to the mitochondria. For this reason, mammalian cells have developed several strategies for their strict regulation throughout evolution. This review aims to highlight the different ways by which BH3-only proteins are controlled, including transcriptional regulation, post-translational modifications and subcellular localization.

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1 Archivum Immunologiae et Therapiae Experimentalis

1 Postępy Higieny i Medycyny Doświadczalnej

1 2003

1 2002

1 Ayllon V.

1 Fleischer A.

1 Goc A.

1 Lenartowski R.

1 Rebollo A.

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Multilevel regulation of the tyrosine hydroxylase. II. Transcriptional regulation

BH3-only proteins: the lords of death