Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 12

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  T LYMPHOCYTE
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1

Antitumor activity of gamma deltaT lymphocytes

100%
Bartkowiak J., Blonski J.
Postępy Higieny i Medycyny Doświadczalnej
|
2000
|
vol. 54
|
issue 1
37-51
EN
Increasing knowledge about the role played by gama delta T lymphocytes in antitumor immunity is of importance to both the fundamental and clinical sciences. Gamma delta T cells are also characterized with reference to their s elf neoplastic transformation and development of leukemias or lymphomas with gamma delta fenotype.
2

IL-15 and IL-15Ra in CD4+T cell immunity

80%
Van_ B. T., Grooten J.
Archivum Immunologiae et Therapiae Experimentalis
|
2005
|
vol. 53
|
issue 2
115-126
EN
The cytokine IL-15 performs numerous functions, such as promotion of growth and survival, on a plethora of cell types from both the lymphoid and non-lymphoid compartments. Therefore, mice genetically engineered to either lack or overexpress functional IL-15 display reduced immunological responses and leukemia, respectively. Surprisingly, IL-15 protein is hardly found in serum or body fluids. Due to the lack of a clear demonstration of its presence as protein, IL-15 was often referred to as a 'ghost cytokine'. Recently, however, membrane-bound IL-15 was detected in both a membrane-anchored form and an IL-15Ralpha-bound form on monocytes. Interestingly, the latter complex can be transpresented to cells expressing the intermediate-affinity IL-2/15Rbeta- gammaC receptor and thereby support the survival and proliferation of T cells. Moreover, overlapping promoter elements indicate a model of co-regulation of IL-15 and IL-15Ralpha by which IL-15 activities are controlled in a cell-contact-dependent manner. In this review, recent reports on IL-15 are combined with previous observations and discussed in terms of their functional consequences for CD4+ T cell responses.
3

The patch-clamp technique in investigations on T lymphocyte potassium channel modulation

80%
Teisseyre A.
|
|
issue 3
393-399
EN
This review focuses on results of patch-clamp studies on modulation of T lymphocyte potassium channel activity by physiologically relevant factors. In the preface the patch-clamp technique is briefly presented and basic properties of potassium channels in T lymphocytes are characterised. The paper contains an overview of the data on modulatory effects of extracellular and intracellular pH, temperature, extracellular potassium, extracellular divalent and trivalent metal cations, channel phosphorylation processes and membrane lipid metabolities on potassium channel activity. Some still unresolved problems in that area are indicated.
4

The interactions of T lymphocytes with elastin and their significance in immunopathology

80%
Targonska M., Gorski A., Kasprzycka M., Nowaczyk M.
|
EN
Recent data indicate that human T lymphocytes can adhere to elastin and respond to co-stimulatory signals of that protein. This reactivity is mediated by non-integrin receptor, elastin binding protein. In addition, another receptor belonging to integrin family may be also involved. T cell interactions with elastin (but not other extracellular matrix proteins) appear to be upregulated in healthy males and at least patients with vasculitis. Interestingly, statins in pharmacological concentrations strongly and selectively block those interactions. Our data point to the potential role of T cell interactions with elastin in immunopathology of vasculitis and atherosclerosis.
5

Peptide loading of nascent MHC class i molecules

80%
Vukmanovic S., Lilic M., Santori F. R., Demaria S., Kulig K.
|
EN
A critical molecular interaction during assembly of the major histocompatibility complex (MHC) class I molecules takes place between the heavy chain and the transporter-associated with antigen-processing (TAP) complex. The recent mapping of regions of the heavy chain involved in the binding to TAP suggests a complex molecular interaction essential for the cell surface expression of the MHC class I. The advances made in understanding the TAP-MHC class I interaction are reviewed and discussed here.
6

Structure and function of T lymphocyte TCR/CD3 complex

80%
Bocko D., Frydecka I.
Postępy Higieny i Medycyny Doświadczalnej
|
2003
|
vol. 57
|
issue 5
519-529
EN
The multichain T cell receptor/CD3 complex (TCR/CD3) plays a key role in antigen recognition, further T cell activation and in consequence in triggering an antigen specific immune response. This process is induced by direct interaction of the TCR receptor with an antigen bound to the major histocompatibile compex on antigen-presenting cells. Upon the structural and functional cooperation of TCR receptor with CD3 complex, the activating signal is transmitted through the cell membrane to the nucleus. The pivotal role in signaling cascade plays CD3-zeta () chain, which triggers many biochemical events and second messenger activation, leading to the transcriptional factors expression and further T cell proliferation, effector function augmentation and cytokine production.
7

The role of dendritic cells in antigen recognition: from antigen uptake to its presentation to T lymphocytes

70%
Kolodziej D., Pajtasz-Piasecka E.
Postępy Higieny i Medycyny Doświadczalnej
|
2003
|
vol. 57
|
issue 2
149-170
EN
The phenomenon of antigen presentation can be divided into three stages. 1/ antigen uptake (recognition and internalization), which first of all concerns exogenous antigens; 2/ intracellular enzymatic antigen processing and protein degradation followed by peptide loading of presenting molecules; 3/ exocytosis of the antigen presenting molecules complex containing: a) MHC class II /exogenous antigens; b) MHC class I/endogenous antigens; c) MHC class I/exogenous antigens (so-called cross-presentation); d) CD1 ? lipids. This review presents the main stages of intracellular transport and the traffic of MHC molecules, which are believed to be different in dendritic cells (DC), in comparison with other antigen presenting cells, and enable DC to play the unique role in the initiation of immune response and the induction of tolerance.
8

T cell integrin activation by chemokines in inflammation

70%
Tanaka Y.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
vol. 48
|
issue 5
443-450
EN
The adhesive function of integrins is regulated through cytoplasmic signaling induced by several stimuli, whose process is designated ?inside-out signaling?. A large number of lymphocytes are recruited to the sites of inflammation where they form an essential component of the response to infection, injury, autoimmune disorders, allergy, tumor invasion, atherosclerosis and so on. The recruitment of leukocytes into tissue is regulated by a sequences of interactions between the circulating leukocytes and the endothelial cells. Leukocyte integrins play a pivotal role in leukocyte adhesion to endothelial cells. During the process, the activation of integrins by chemokines, is essential for integrin-mediated adhesion in which a signal transduced to the leukocyte converts the functionally inactive integrin to an active adhesive configuration. The present review documents the relevance of cytoplasmic signaling and cytoskeletal assembly to integrin-mediated adhesion induced by chemokines during inflammatory processes.
9

Mechanisms of cellular cytotoxicity. I. The stages of

70%
Janiak M., Budzynski W.
|
|
vol. 47
|
issue 3
169-182
EN
This review describes the stages of mediated by , cytotoxic , natural killer cells and .
10

Regulation of human T lymphocyte potassium channel function by intracellular second messengers ? role of calcium, cyclic AMP and membrane lipid metabolities

70%
Teisseyre A.
Postępy Higieny i Medycyny Doświadczalnej
|
2000
|
vol. 54
|
issue 3
381-390
EN
This review focuses on the influence of well-known intracellular second messengers on the activity of potassium channels expressed in human T lymphocytes. Basic biophysical properties of the channels are briefly presented. Available data on the regulatory role of intracellular calcium and cyclic AMP is reviewed. Finally, a possible influence of lipid compounds, especially high-density lipoproteins, lysophospholipids and sphingolipids, on the expression and activity of potassium channels in human T lymphocytes is discussed.
11

Pathogenetic mechanisms of atopic dermatitis

70%
Pastore S., Giustizieri M. L., Mascia F., Giannetti A., Girolomoni G.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
vol. 48
|
issue 5
497-504
EN
Atopic dermatitis (AD) is a chronic inflammatory disease which results from complex interactions between genetic and environmental mechanisms. An altered lipid composition of the stratum corneum is responsible of the xerotic aspect of the skin, and determines a higher permeability to allergens and irritants. Keratinocytes of AD patients exhibit a propensity to an exaggerated production of cytokines and chemokines, a phenomenon that can have a major role in promoting and maintaining inflammation. Specific immune responses against a variety of environmental allergens are also implicated in AD pathogenesis with a bias towards Th2 immune responses. In particular, dendritic cells expressing membrane IgE receptors, play a critical role in the amplification of allergen-specific T cell responses. Cross-linkage of specific IgE receptors on dermal mast cells provokes release and synthesis of a vast series of mediators. Following their recruitment and activation into the skin, eosinophils are also thought to contribute relevantly to tissue damage. Thus, a complex network of cytokines and chemokines contributes to establish a local milieu that favors the permanence of inflammation in AD skin.
12

Rethinking globally relevant vaccine strategies to human immunodeficiency virus type-1

61%
Gray C. M., Puren A. J.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
vol. 48
|
issue 4
235-241
EN
According to the latest UNAIDS figures for 1999 there were an estimated 30. 6 million people living with HIV-1, with 16000 new HIV infections per day. The only global strategy of combating new HIV infections is to make a vaccine that is affordable to developing countries, where greater than 90% of new infections occur, and that has enough efficacy to interrupt high rates of transmission. This review critically examines: 1) important immune parameters that should be considered which will allow an understanding of preventative vaccine design and 2) the mechanisms underlying immune destruction during HIV-1 infection that will facilitate design of therapeutic vaccines. A realistic goal of a preventative vaccine is to elicit protective immune responses in vaccinees that would prevent HIV-1 from replicating extensively in the host. Components of protective immunity are thought to include neutralizing antibodies (NAB) and cytotoxic T lymphocytes (CTL). Rethinking vaccine strategies has to take into account that HIV-1 vaccines must elicit primary cellular and humoral immunity via dendritic cell and Langerhan cell priming. It is only under these conditions that boosting immunity with subsequent vaccinations will allow high enough CTL effector cells and NAB titres to impede or to prevent HIV-1 replication. Success of therapeutic vaccine strategies, has to take into consideration the pathology of persistent immune stimulation by chronic HIV-1 infection. To re-stimulate immunity and re-direct immune responses, chronic immune stimulation by HIV-1 has to be alleviated by reducing high levels of viral antigen presentation by suppressing virus with antiretroviral agents. Such treatment courses may only have to be transient, long enough for immunity to respond to an immunogenic stimulus. Short-course drug therapy may then be an affordable option for many countries already carrying a high burden of HIV-1/AIDS.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.