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1
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Survival of patients with head and neck squamous cell carcinoma in association with human papillomavirus and p53 polymorphism

100%
Gudleviciene Z., Smailyte G.
Open Medicine
|
2012
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vol. 7
|
issue 3
349-353
2
Content available remote

Independent prognostic factors in endometrial cancer: a single institution review

100%
Uharček P., Mlynček M., Ravinger J., Lajtman E., Matejka M.
Open Medicine
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2011
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vol. 6
|
issue 3
294-299
EN
The purpose of this study was to conduct a clinical and pathologic review of endometrial cancers diagnosed and surgically treated in our institution to evaluate results of treatment in relation to current international recommendations. We retrospectively evaluated the clinical history, treatment and follow-up of patients with histologically confirmed endometrial cancer treated in Faculty Hospital Nitra, Slovakia from 1990 to 2005. Data were abstracted regarding tumor histology, grade, age, parity, stage, diabetes, use of oral contraceptives, BMI, survival and treatment modalities including surgery, radiation therapy, chemotherapy, hormonal therapy, and combinations thereof. One hundred and thirty nine patients received surgical treatment for endometrial cancer: stage I -101 (72,6%), stage II - 9 (6,5%), stage III - 23 (16,6%) and stage IV - 6 (4,3%). Tumors were well differentiated in 87(62,6%), moderately differentiated in 32 (23%) and poorly differentiated in 20 (14,4%). There were 45 (32,4%) premenopausal patients and 94 (67,6%) postmenopausal. In multivariate statistical analysis we identified FIGO stage, tumor type, tumor grade, nodal status and depth of myometrial invasion as independent prognostic factors for overall survival, and FIGO stage, nodal status, and tumor grade as independent prognostic factors for recurrence-free interval.
3
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Effects of winter survival training on selected motor indices

100%
Tomczak A.
Biomedical Human Kinetics
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2010
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vol. 2
62-65
EN
Study aim: To assess the effects of prolonged winter survival activities of moderate workouts on selected motor skills in male participants of survival instructor training course.Material and methods: A group of 11 physical education students, participants of a survival course camp for instructors, aged 21 - 25 years, participated in the study. They were examined 3 times: before starting the course (Day 1), on the following morning - after a 12-h night training when the participants were deprived of sleep (Day 2) and 24 h later, after a 6-h sleep and survival activities lasting all day (Day 3). At the end of the course all the participants were assessed by a single 10-point scale. In the mornings of all 3 days the participants were subjected to the following tests: 15-m straight run, shuttle run 3×5 m, 15-slalom run, 15-m squat, computer-aided co-ordination test, maximum handgrip, 50%-handgrip and corrected 50% handgrip.Results: Running velocity on Day 3 was significantly (p<0.05) decreased in relation to the previous days but a running performance index computed from the standardised values of all running tests did not decrease and on Day 2 was even significantly (p<0.05) higher than on Day 1. No significant between-day differences were found for the visual co-ordination test and for handgrip strength indices despite exhausting workloads applied.Conclusions: Although the applied tests did no fully reflect the real performance of subjects under the winter survival conditions, it seems that engaging soldiers in consecutive military actions without an adequate recovery should be avoided whenever possible in order to improve the execution of strenuous tasks.
4
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Peripheral blood CD4+CRTH2+ cells in advanced stage non small cell lung cancer

88%
Karagöz B., Bilgi O., Kandemir E., Erikçi A., Sayan Ö., Özgün A., Yılmaz B., Türken O., Alacacıoğlu A., Öztürk A.
Open Medicine
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2010
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vol. 5
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issue 4
431-436
EN
To investigate CD4+CRTH2+ cells in peripheral blood in advanced stage non small cell lung cancer (NSCLC) patients. Forty-six patients with advanced stage NSCLC, who are chemotherapy or radiotherapy naïve, and 17 healthy volunteers, were enrolled in this study. The study was performed using flow cytometry and a complete blood cell counter analyser. CD4+ T cell percentage, CD4/CD8 ratio, CRTH2+CD4+ cell percentages, counts, and mean fluorescein intensity (MFI) and hematological parameters were evaluated in both groups. A survival analysis was performed to compare the patients with high CD4+CRTH2+ cell percentage and those with low CD4+CRTH2+ percentage. CD4+ T cell percentage in total lymphocytes and the CD4/CD8 ratio were lower in the patient group than in the control group. The absolute CD8 T cell count was higher in the patient group than in the control group, whereas the total T cells was not different. The CRTH2+ cell percentage in CD4+ T cells (7.96% ± 6.21% vs 3.37% ± 3.55%; respectively; p: 0,001) and the absolute count of CRTH2+CD4+ cells ( 97 mm-3 ± 109 mm-3 vs 37 mm-3 ± 38 mm-3, respectively; p: 0,033) in the patient group were higher than in the control group, but CRTH2-PE MFI values were not different between groups. Cox regression analysis did not show that CRTH2+CD4+ cell count or percentage is an independent prognostic factor. The study found that CRTH2 expression of CD4+ T cells and CRTH2+CD4+ cell number are higher in the peripheral blood of NSCLC patients than in that of healthy subjects. Further studies that explore the biological significance of high CD4+CRTH2+ cells in lung cancer patients, should be pursued.
5
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Blood pressure categories and mortality during a thirty-six-year follow-up

75%
Stojanov V., Paunović K., Jakovljević B., Lović D., Jurisić V.
Open Medicine
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2013
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vol. 8
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issue 2
229-236
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