Search results

1

Antibacterial activity of covered paper after storage

100%

Jarosz M., Sumińska P., Kowalska U., Mizielińska M.

World News of Natural Sciences

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2018

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vol. 17

141-146

EN

The paper covered with a hydrophobic Topscreen coating was coated with the second layer. The goal of paper covering was to obtain the antimicrobial properties of the external coating. The samples were stored 2 months at 20 ºC. The influence of storage on the antimicrobial properties of the external coating was analyzed. The results of the study showed that paper covered with Topscreen coating did not have an influence on the growth of Staphylococcus aureus cells. The second (external) layer containing 2% polylysine as an active substance decreased the growth of S. aureus. The 2 months storage of the covered paper did not influence the antimicrobial properties of coating with polylysine against S. aureus. It was demonstrated that paper covered with hydrophobic coating had no influence on the growth of E. coli cells as well. In this case the influence of 2 months storage on the antimicrobial properties of the coating with polylysine was observed. In contrast to the results obtained for the samples that were not store, the decrease of the growth of the bacterial cells after 24 h contact with a hydrophobic coating devoid of an active substance was noticed.

2

Surgical site infections – review of current knowledge, methods of prevention

100%

Kolasiński W.

Polish Journal of Surgery

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2019

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vol. 91(4)

41-47

EN

Introduction: Surgical site infections have accompanied humanity since the dawn of time. Development of medicine has reduced their percentage, but still they are a huge problem to face with. Surgical site infections cause a significant increase in a cost of hospitalization. This is the main reason why the whole scientific world is looking for prevention of these complications. Materials and methods: The aim of the paper is to present current views on the etiology and methods of prevention of surgical site infection. Results: Patients own pathogens are most often responsible for surgical site infections. In hospitalizations over 5–7 days exogenous and hospital flora have the advantage. The most common isolated pathogen is Staphylococcus aureus. The percentage of MRSA – resistant methicillin strains is increasing. Pre-operative antibiotic therapy reduces the frequency of surgical site infection in many surgical procedures. Time of administration, type and dose of antibiotic play an important role in preventing post-operative infections. Pre-operative skin antiseptic is also important. The two most commonly used ingredients are chlorhexidine gluconate and povidone iodine. Recent reports point the chlorhexidine alcohol solution as an agent with a higher degree of efficacy. Conclusions: In 2017 Centers for Disease Control and Prevention published the new guidelines for prevention of surgical site infections. This practical tips and tricks should be implemented to every surgical procedure.

3

Leonurus cardiaca L. herb - a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis

100%

Micota B., Sadowska B., Podsędek A., Redzynia M., Różalska B.

Acta Biochimica Polonica

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2014

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vol. 61

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issue 2

385-388

EN

The objective was an assessment of the impact of Leonurus cardiaca L. extract (LCE) and ursolic acid (UA) on the adhesive properties of Staphylococus aureus NCTC 8325 strain, expressing virulence factors important in the pathogenesis of infective endocarditis. The adhesion and biofilm formation of bacteria cultured in the presence of subinhibitory concentrations of LCE or UA on the abiotic surface or covered with fibrinogen, fibronectin or collagen, were evaluated. Inhibitory effects of LCE and UA on staphylococcal adherence to both types of surface were demonstrated. This, in the case of UA, resulted in a significant reduction of biofilm formation.

4

Zakażenia miejsca operowanego – przegląd aktualnej wiedzy, metody zapobiegania

100%

Kolasiński W.

Polish Journal of Surgery

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2019

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vol. 91(4)

41-47

PL

Wstęp: Infekcje miejsca operowanego (ang. Surgical site infections – SSI) towarzyszą ludzkości od zarania dziejów. Wraz z rozwojem medycyny udało się zmniejszyć ich odsetek, jednak do dziś stanowią poważny problem, z którym mierzymy się każdego dnia. Zakażenia miejsca operowanego powodują wzrost kosztów leczenia. Dlatego też na całym świecie poszukuje się metod skutecznego zapobiegania tym powikłaniom. Materiały i metody: Celem pracy jest przedstawienie aktualnych poglądów na temat etiologii i sposobów zapobiegania infekcjom miejsca operowanego. Wyniki: Za zakażenia miejsca operowanego najczęściej odpowiadają patogeny własne chorego. Dopiero przy hospitalizacjach powyżej 5–7 dni przewagę zdobywa flora egzogenna, szpitalna. Głównie izolowanym patogenem jest Staphylococcus aureus. Rośnie odsetek szczepów metycylinoopornych – MRSA. Przedoperacyjna antybiotykoterapia przyczynia się do zmniejszania częstości infekcji miejsca operowanego w wielu procedurach chirurgicznych. Czas podania, rodzaj i dawka antybiotyku, odgrywają ważną rolę w zapobieganiu infekcjom pooperacyjnym. Również antyseptyka pola operacyjnego jest istotna. Dwa najczęściej używane składniki to: glukonian chlorheksydyny i jodpowidon. Najnowsze doniesienia wskazują na alkoholowy roztwór chlorheksydyny jako ten o wyższym stopniu skuteczności. Wnioski: W 2017 roku Europejskie Centrum ds. Zapobiegania i Kontroli Chorób (ang. Centers for Disease Control and Prevention) opublikowało wytyczne przedstawiające nowe i zaktualizowane zalecenia dotyczące zapobiegania SSI. Powinny one zostać wprowadzone do postępowania chirurgicznego w celu poprawy bezpieczeństwa pacjentów.

5

Nasal Carriage of MRSA Strains Among Hospital Employees in a Surgical Department

100%

Tur W., Kielar M., Kłaczkowska A., Teodorowicz E., Lewczuk A.

Polish Journal of Surgery

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2010

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vol. 82

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issue 3

166-169

EN

The aim of the study was to estimate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) strain carriage among hospital employees who have contact with patients treated at the General and Vascular Surgery Teaching Hospital of the Capital Bródnowski Hospital. Comparison of the findings with results from similar studies performed in various medical centers around the world.Material and methods. Using microbial cultures, we screened for nasal carriage of MRSA strains in hospital employees who have contact with patients at the General and Vascular Surgery Teaching Hospital. The medical and custodial staff of the Faculty of General and Vascular Surgery, Anesthesiology and Operating Suite were studied. If MRSA strains were present on bacterial cultures, identification of the strain was further confirmed using molecular methods, including reverse transcription polymerase chain reaction (RT-PCR). Examinations were performed in collaboration with the Department of Epidemiology and Clinical Microbiology of the National Medicines Institute.Results. The carriage rate confirmed by molecular techniques was 4.5%. Confirmed cases of MRSA carriage in hospital staff underwent eradication with a five-day treatment scheme of intranasal 2% mupirocin ointment. Control results confirmed its effectiveness.Conclusions. The prevalence of nasal carriage of MRSA among the medical and custodial staff screened was 4.5%. This prevalence of carriage among medical employees is similar to the rate of carriage in the general population. This finding suggests a low rate of bacterial transmission between the faculty, staff, and patients. Eradication of MRSA with the use of a five-day course of 2% intranasal mupirocin ointment is an effective method of controlling carriage among medical staff as well as among the general public.

6

Isolation of vanconycin resistant Staphylococcus aureus from the wounds of hospital patients in Uyo, Akwa Ibom State, Nigeria

88%

Anosike I. K., Ebana R. U. B., Edet U. O., Umoh I. S.

World News of Natural Sciences

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2019

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vol. 24

134-144

EN

Staphylococcus aureus is a very important human pathogen that generates a number of human infections. Isolation of vancomycin-resistant Staphylococcus aureus (VRSA) was carried out from wound samples of patients attending University of Uyo Teaching Hospital, Akwa Ibom state, Nigeria. A total of 45 wound samples from 15 patients were collected aseptically in triplicate, using sterile cotton swabs moistened in sterile normal saline. Microbiological analysis and susceptibility to vancomycin, including minimum inhibitory and minimum bactericidal concentrations (MIC and MBC), were carried out using standard methodologies. A total of 15 isolates were obtained and these showed varying MIC and MBC patterns. Out of the 15 S. aureus isolated, only one isolate had an MIC of approximately 4 µg/ml, while twelve isolates gave MIC values that ranged from 15.62 µg/ml to 250 µg/ml. The remaining 2 isolates gave MIC values that were ≥ 500 µg/ml. These 2 isolates exhibited alpha haemolysis on blood agar, unlike the others that were beta haemolytic. The results of the MBC also showed variations amongst the isolates. A total of 10 isolates gave MBC values that ranged from 62.5 µg/ml to 500 µg/ml, while the remaining 5 isolates gave MBC values that were ≥ 500 µg/ml. The high MIC and MBC values obtained showed that vancomycin-resistant Staphylococcus aureus is increasing at an alarming rate, and this accounts for the gradual decline in the effectiveness associated with the use of vancomycin. Given the widespread prevalence of VRSA, there is a need for newer therapeutics that can reverse this surge.

7

Biosynthesis of cobalt oxide (Co3O4) nanoparticles using plant extract of Camellia sinensis (L.) Kuntze and Apium graveolens L. as the antibacterial application

88%

Urabe A. A., Aziz W. J.

World News of Natural Sciences

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2019

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vol. 24

356-364

EN

In this work, we prepared cobalt oxide nanoparticles using Celery stalks and green tea leaves extract. The synthesized cobalt-oxide NPs were characterized using X-Ray diffraction. This showed the highest peak and top control (222) at (38.18 degree) with regard to Camellia sinensis extract and (220) at (30.14 degree) for Apium graveolens extract, Field Emission scanning electron microscopy (EF_SEM) at the range of 21-72 nm, revealed the highly uniform shape of particles, while UV-Visible spectroscopy techniques recorded the highest value of the absorptive at 230 nm and the energy band gap to be 3.55 eV for Camellia sinensis and 225 nm and energy band gap 3.85 eV at Apium graveolens, respectively. Our results indicate that the best achievable result in inhibiting bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa comes by way of using Camellia sinensis extract (27-29 mm).

8

Wyprysk pieniążkowaty u 3-letniego chłopca – opis przypadku

88%

Pogonowska M., Dobrowiecka K., Przekora J., Wawrzyniak A., Kalicki B.

Pediatria i Medycyna Rodzinna

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2017

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vol. 13

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issue 4

547-554

EN

Nummular eczema (eczema nummulare) is a chronic, recurrent idiopathic dermatitis. Its name is derived from specific papular and vesicular lesions which merge into coin-shaped patches. These eruptions, which cause heavy pruritus, are usually confined to the lower extremities and the torso. The disease primarily affects elderly individuals. Despite numerous studies, the aetiology of this condition remains unknown. The suspected predisposing factors include chronic stress, excessive dryness of the skin and infections. Severe drug-induced forms of the disease are also known. Differential diagnosis of nummular eczema should include, alongside atopic dermatitis: fungal infection, drug-induced rash and psoriasis. Topical treatment, which focuses on the reconstruction of the protective layer of the skin, limiting inflammation and combating bacterial superinfection, involves the use of glucocorticosteroids and emollients as first-line therapy. If first-line treatment proves ineffective, immunomodulatory drugs are recommended. Secondary superinfection of the lesions with Staphylococcus aureus is a fairly common complication. In such a case both topical and systemic antibiotic therapy is indicated. This paper discusses the case of nummular eczema with Staphylococcus aureus superinfection in a 3.5-year-old boy hospitalised at the Department of Paediatrics, Paediatric Nephrology and Allergology of the Military Institute of Medicine in Warsaw, Poland.

PL

Wyprysk pieniążkowaty (eczema nummulare) to idiopatyczna choroba zapalna skóry o charakterze przewlekłym i nawrotowym, która swą nazwę zawdzięcza specyficznym zmianom grudkowym i pęcherzykowym zlewającym się w ogniska o monetowatym kształcie. Lokalizacja tych silnie swędzących wykwitów ogranicza się zwykle do kończyn dolnych i tułowia. Schorzenie dotyczy głównie osób w starszym wieku. Mimo licznych badań etiologia choroby wciąż pozostaje nieznana. Podejrzewane czynniki predysponujące to przewlekły stres, nadmierne wysuszenie skóry oraz infekcje. Znane są również ciężkie polekowe postacie tej choroby. W diagnostyce różnicowej wyprysku pieniążkowatego poza atopowym zapaleniem skóry należy rozważyć również infekcję grzybiczą, wysypkę polekową i łuszczycę. W leczeniu miejscowym, ukierunkowanym głównie na odbudowanie warstwy ochronnej skóry, ograniczenie stanu zapalnego i wyeliminowanie nadkażenia bakteryjnego, w pierwszym rzucie mają zastosowanie glikokortykosteroidy wraz z emolientami. W przypadku nieskuteczności terapii pierwszorzutowej zaleca się stosowanie leków immunomodulujących. Dość częstym powikłaniem jest wtórne nadkażenie zmian przez Staphylococcus aureus. W takim przypadku wskazana jest antybiotykoterapia zarówno w formie miejscowej, jak i ogólnej. W niniejszej pracy omówiono postać wyprysku pieniążkowatego nadkażonego Staphylococcus aureus u 3,5-letniego chłopca hospitalizowanego w Klinice Pediatrii, Nefrologii i Alergologii Dziecięcej Wojskowego Instytutu Medycznego w Warszawie.

9

Nasal carriage of various staphylococcal species in small ruminant lentivirus-infected asymptomatic goats

88%

Moroz A., Szaluś-Jordanow O., Czopowicz M., Brodzik K., Petroniec V., Augustynowicz-Kopeć E., Lutyńska A., Roszczynko M., Gołoś-Wójcicka A., Korzeniowska-Kowal A., Gamian A., Mickiewicz M., Frymus T., Petelicka H., Kaba J., Moroz A., Szaluś-Jordanow O., Czopowicz M., Brodzik K., Petroniec V., Augustynowicz-Kopeć E., Lutyńska A., Roszczynko M., Gołoś-Wójcicka A., Korzeniowska-Kowal A., Gamian A., Mickiewicz M., Frymus T., Petelicka H., Kaba J.

Polish Journal of Veterinary Sciences

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2020

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vol. 23

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issue 2

10

Evaluation of P1' substrate specificity of staphylococcal SplB protease

88%

Pustelny K., Stach N., Wladyka B., Dubin A., Dubin G.

Acta Biochimica Polonica

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2014

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vol. 61

|

issue 1

149-152

EN

Staphylococcus aureus is a dangerous human pathogen characterized by growing antibiotic resistance. Virulence of S. aureus relies on a variety of secreted and cell surface associated virulence factors among which certain proteolytic enzymes play an important role. Amid staphylococcal extracellular proteases, those encoded by the spl operon remain poorly characterized, both in terms of enzymology and their physiological role. Initial data demonstrated that Spl proteases exhibit restricted substrate specificity. This study describes development of convenient protein FRET substrates for SplB protease and characterization of the substrate preference of the protease at the P1' position. Kinetic data on hydrolysis of a panel of substrates substituted at the said position is provided.

11

Anti-staphylococcal potential of Callistemon rigidus

88%

Gomber C., Saxena S.

Open Medicine

|

2007

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vol. 2

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issue 1

79-88

EN

The last decade witnessed the emergence of Staphylococcus aureus- a versatile human pathogen, as a deadly superbug. The enormous genetic plasticity of the organism assists it to endlessly evolve resistance mechanisms against existing anti-infectives thus necessitating the need to control the spread of resistant staphylococcal isolates in hospitals and health care settings. This in turn demands the incessant exploration of newer biological matrices in search of diverse chemical entities with novel drug targets. Since time immemorial higher plants continue to be the best source of newer compounds with high therapeutic potential. Lead fractions from same or different plants can be developed into effective antibacterial polyherbal formulations. A lead fraction from methanolic extract of leaves of Callistemon rigidus exhibited a dose dependent antistaphylococcal activity during in vitro agar well assay against a panel of twenty seven clinical multidrug resistant S. aureus isolates. Further, minimal inhibitory concentration (MIC) evaluation by in vitro 96-well microplate based assay established a MIC range of 1.25–80 μg/ml as compared to 5–320 μg/ml of positive control, Cefuroxime sodium. The MIC50 and MIC90 of the methanolic lead fraction were 5 μg/ml and 40 μg/ml respectively. The present study thus signifies the vast potential of the lead fraction from Callistemon rigidus for future development into a herbal drug/ formulation and to impede global health crisis due to multidrug resistant Staphylococcus aureus.

12

Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity

88%

Plata K., Rosato A., Węgrzyn G.

Acta Biochimica Polonica

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2009

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vol. 56

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issue 4

597-612

EN

Although it is estimated that 20-30% of the general human population are carriers of Staphylococcus aureus, this bacterium is one of the most important etiological agents responsible for healthcare-associated infections. The appearance of methicillin resistant S. aureus (MRSA) strains has created serious therapeutical problems. Detailed understanding of the mechanisms of S. aureus infections seems necessary to develop new effective therapies against this pathogen. In this article, we present an overview of the biochemical and genetic mechanisms of pathogenicity of S. aureus strains. Virulence factors, organization of the genome and regulation of expression of genes involved in virulence, and mechanisms leading to methicilin resistance are presented and briefly discussed.

13

Proteomics in studies of Staphylococcus aureus virulence

88%

Bonar E., Wójcik I., Wladyka B.

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issue 3

367-381

EN

Staphylococcus aureus is a widespread, opportunistic pathogen that causes community and hospital acquired infections. Its high pathogenicity is driven by multifactorial and complex mechanisms determined by the ability of the bacterium to express a wide variety of virulence factors. The proteome secreted into extracellular milieu is a rich reservoir of such factors which include mainly nonenzymatic toxins and enzymes. Simultaneously, membrane proteins, membrane-cell wall interface proteins and cell wall-associated proteins also strongly influence staphylococcal virulence. Proteomics shows a great potential in exploring the role of the extracellular proteome in cell physiology, including the pathogenic potential of particular strains of staphylococci. In turn, understanding the bacterial physiology including the interconnections of particular factors within the extracellular proteomes is a key to the development of the ever needed, novel antibacterial strategies. Here, we briefly overview the latest applications of gel-based and gel-free proteomic techniques in the identification of the virulence factors within S. aureus secretome and surfacome. Such studies are of utmost importance in understanding the host-pathogen interactions, analysis of the role of staphylococcal regulatory systems and also the detection of posttranslational modifications emerging as important modifiers of the infection process.

14

Differences in metabolic profiles of planktonic and biofilm cells in Staphylococcus aureus - 1H Nuclear Magnetic Resonance search for candidate biomarkers

88%

Junka A., Deja S., Smutnicka D., Szymczyk P., Ziółkowski G., Bartoszewicz M., Młynarz P.

Acta Biochimica Polonica

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2013

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vol. 60

|

issue 4

701-706

EN

Staphylococcus aureus is responsible for many types of infections related to biofilm presence. As the early diagnostics remains the best option for prevention of biofilm infections, the aim of the work presented was to search for differences in metabolite patterns of S. aureus ATCC6538 biofilm vs. free-swimming S. aureus planktonic forms. For this purpose, Nuclear Magnetic Resonance (NMR) spectroscopy was applied. Data obtained were supported by means of Scanning Electron Microscopy, quantitative cultures and X-ray computed microtomography. Metabolic trends accompanying S. aureus biofilm formation were found using Principal Component Analysis (PCA). Levels of isoleucine, alanine and 2,3-butanediol were significantly higher in biofilm than in planktonic forms, whereas level of osmoprotectant glycine-betaine was significantly higher in planktonic forms of S. aureus. Results obtained may find future application in clinical diagnostics of S. aureus biofilm-related infections.

15

Comparative Anti-Bacterial Effect of Aqueous and Ethanolic Stem Barks of Tamarindus indica Linn on Staphylococcus aureus

88%

Boyi D. I., Sani L. A.

|

EN

This study focuses on Tamarindus indica, a plant belonging to family Fabaceae commonly found in Nigeria and the Asian continent, and explores the potential comparative antibacterial activity of its aqueous and ethanolic stem barks against Staphylococcus aureus, a Gram-positive bacterium. The stem barks of Tamarindus indica were obtained from a live Tamarind tree located at Bayero university Kano, old campus, was dried under shade away from direct sunlight in the laboratory, pounded to fine powder using mortar and pestle and extracted through maceration method using distilled water and ethanol solvents. Phytochemical analysis was carried out following standard procedures and it revealed the presence of alkaloids, flavonoids, tannins, saponins, phenols, terpenoids, steroids, glycosides, and carbohydrates in the extracts. Agar well diffusion method was employed to assess the antibacterial activity. The results showed the aqueous extracts exhibited bigger zones of inhibition compared to the ethanol extracts. Furthermore, the lowest MIC was 15.625 mg/ml for ethanolic Stem bark extract revealing how effective the stem bark ethanol extracts were in combating the bacteria. The study demonstrated that Tamarindus indica stem barks possesses antibacterial properties which may be attributed to the presence of bioactive compounds such as alkaloids, flavonoids, tannins, and phenols and highlights the potential of Tamarindus indica as an affordable and accessible natural remedy against Staphylococcus aureus infections and diseases.

16

Characteristics of advanced methods used for typing bacterial isolates from mastitis with particular reference to Staphylococci

75%

Lisowska-Łysiak K., Dudko P., Kosecka-Strojek M., Walczak J., Wójcik P., Międzobrodzki J.

Polish Journal of Veterinary Sciences

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2018

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vol. 21

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issue 1

17

Antimicrobial coatings as a promising prevention strategy of implants infections triggered by Staphylococcus aureus

75%

Malicki M., Bielec F., Brauncajs M., Pastuszak-Lewandoska D.

Alergia Astma Immunologia - przegląd kliniczny

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2023

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vol. 28

|

issue 1

2-7

PL

Postęp technologiczny w tworzeniu różnego typu implantów jest jednym z największych osiągnięć współczesnej chirurgii. Takie urządzenia mogą zastąpić lub przywrócić funkcję uszkodzonych tkanek, co znacząco poprawia jakość i długość życia pacjentów. Niestety infekcje są głównym powodem usuwania implantów. Pacjenci wymagają też zazwyczaj trudnego i kosztownego leczenia. Gronkowiec złocisty jest najczęściej wykrywanym patogenem w tego typu powikłaniach. Powoduje to, że metody profilaktyczne zyskują na atrakcyjności. Najważniejszymi technikami umożliwiającymi zapobieganie infekcjom implantów są pokrycia przeciwdrobnoustrojowe. Dzięki nim biomateriały, z których otrzymywane są urządzenia medyczne mogą uzyskać właściwości antyadhezyjne i bakteriobójcze. W niniejszej pracy dokonujemy przeglądu obiecujących metod tworzenia takich pokryć. Większość koncepcji dotyczy pokrywania implantów substancjami bakteriobójczymi, takimi jak antybiotyki czy nanocząsteczki srebra. Co ciekawe, nawet zmiany w topografii powierzchni mogą być konieczne, aby skutecznie zapobiec adhezji gronkowca złocistego.

EN

Technological progress in the development of various types of implants is one of the greatest achievements of contemporary surgery. Such devices can replace or restore the function of damaged tissues, significantly improving people’s quality of life and its longevity. Unfortunately, infections are the main reason for removing implants from patients who usually then need expensive and challenging treatment. Staphylococcus aureus is the most frequent pathogen detected in such complications. Therefore, prevention methods become more attractive. Antimicrobial coatings are the most important techniques to prevent implant infections. They give the biomaterials from which medical devices are obtained antiadhesive and antibacterial properties. In this paper, we review promising methods of creating such coatings. The majority of concepts are about covering implants with germicidal substances like antibiotics or silver nanoparticles. Interestingly, even changes in the surface topography may be necessary to prevent Staphylococcus aureus adhesion effectively

18

Antibacterial activity of (PVP-ZrO2) nanocomposite against pathogenic bacteria

75%

Abdulrazaq R. A., Al-Ramadhan Z. A., Khalaf H. H.

World News of Natural Sciences

|

2018

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vol. 18

|

issue 2

187-194

EN

The antibacterial activity of a PVP-ZrO2 nanocomposite was investigated against pathogenic bacteria S. aureus and K. pneumoniae after antibacterial sensitivity was determined and one isolate was chosen that showed more antibiotic resistance. Herein, the Co-culture technique was used to calculate percent reduction of bacteria. The results that were obtained in this method show that ZrO2 nanoparticles have inhibitory effect against pathogenic bacteria gram negative bacteria and gram positive bacteria - with reduction of growth reaching 100% to both S. aureus and K. pnumoniae at 5, 10, 15, 20 and 25% ZrO2, compared with control. The resistance patterns of S. aureus and K.pnuemonia isolates show the Moxifloxacin (MXF) is the best antibiotic for both bacteria - with sensitivity at 100%, while resistance to Ceftriaxone (CRO) is at 90% S. aureus, and at 80% K. pnumoniae. The polymer-nanocomposite was prepared by weight percentage wt. % of (PVP) being dissolved in (10) ml of distilled water, with weight percentages 5%, 10%, 15%, 20% and 25% of ZrO2 nanoparticles added.

19

Antibiofilm activity against Staphylococcus aureus and content analysis of Taraxacum Officinale phenolic extract

75%

Xu P., Xu X. B., Khan A., Fotina T., Wang S. H., Xu P., Xu X. B., Khan A., Fotina T., Wang S. H.

Polish Journal of Veterinary Sciences

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2021

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vol. 24

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issue 2

20

Sepsa jako powikłanie drobnego zranienia

63%

Jurkiewicz B.

Pediatria i Medycyna Rodzinna

|

2010

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vol. 6

|

issue 4

324-327

EN

Sepsis is a severe generalised infection caused usually by pathogenic bacteria. Natural defence mechanisms are destroyed by bacterial toxin and systemic inflammatory response syndrome (SIRS) is developed. High virulence pathogens like meningococcus, pneumococcus, Haemophilus influenzae, Salmonella, Streptococcus, Staphylococcus (generally Staphylococcus aureus) are factors causing general infection. Other microorganisms causing SIRS are viruses, fungus, or parasites. Mechanisms developing sepsis are complex. Respiratory system, infection in abdominal cavity, encephalomyelitis, and urinary system infection are usually entry of septicaemia. Particular type of infection is sepsis developed after surgical procedure or invasive diagnostic investigation. Rare cause of fully symptomatic SIRS are small skin wounds causing damage of skin barrier and penetration of skin bacteria inside the organism. In propitious conditions i.e. decrease of immunity bacteria can spread via bloodstream, destroy vessel endothelium and provoke septic shock. The article presents two cases of sepsis induced by Staphylococcus aureus. No other deviation but small wounds were found in general state of those children. Early diagnostics and highly specialistic treatment carried out on Pediatric Surgery and Orthopedics Department resulted in complete recovery of presented patients.

PL

Sepsa jest to ciężkie uogólnione zakażenie, powstające najczęściej na skutek zakażenia bakteriami chorobotwórczymi. Toksyny bakteryjne uszkadzają naturalne mechanizmy obronne organizmu, wywołując uogólniony zespół odczynu zapalnego (SIRS). Do czynników wywołujących zakażenie należą bakterie chorobotwórcze o dużej zjadliwości, takie jak: meningokoki, pneumokoki, pałeczka hemofilna, salmonella, paciorkowce czy gronkowce (najczęściej Staphylococcus aureus). Innymi drobnoustrojami odpowiadającymi za wystąpienie zespołu SIRS mogą być wirusy, grzyby lub pasożyty. Mechanizm powstawania sepsy jest złożony. Wrotami zakażenia krwi najczęściej są układ oddechowy, infekcje w obrębie jamy brzusznej, zapalenie opon mózgowo-rdzeniowych i zakażenia układu moczowego. Szczególnym rodzajem zakażenia jest sepsa rozwijająca się po zabiegach operacyjnych lub inwazyjnych badaniach diagnostycznych. Rzadką przyczyną wystąpienia pełnoobjawowego zespołu SIRS mogą być drobne zranienia skóry powodujące uszkodzenie bariery skórnej i przeniknięcie do organizmu bakterii, które zwykle znajdują się na powierzchni skóry. W sprzyjających warunkach, na przykład zmniejszonej odporności, mogą one rozprzestrzenić się drogą krwionośną, uszkadzając śródbłonek naczyń, i w efekcie wywołać wstrząs septyczny. W pracy przedstawiono dwa przypadki sepsy wywołanej bakterią Staphyloccocus aureus u dzieci, u których stwierdzono jedynie drobne zranienia skóry bez żadnych innych odchyleń od stanu prawidłowego. Wczesna diagnostyka i wczesne wysokospecjalistyczne leczenie wprowadzone w Oddziale Chirurgii i Ortopedii Dziecięcej pozwoliło na opanowanie sepsy i doprowadziło do całkowitego wyleczenia dzieci.

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Antibacterial activity of covered paper after storage

Surgical site infections – review of current knowledge, methods of prevention

Leonurus cardiaca L. herb - a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis

Zakażenia miejsca operowanego – przegląd aktualnej wiedzy, metody zapobiegania

Nasal Carriage of MRSA Strains Among Hospital Employees in a Surgical Department

Isolation of vanconycin resistant Staphylococcus aureus from the wounds of hospital patients in Uyo, Akwa Ibom State, Nigeria

Biosynthesis of cobalt oxide (Co3O4) nanoparticles using plant extract of Camellia sinensis (L.) Kuntze and Apium graveolens L. as the antibacterial application

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Nasal carriage of various staphylococcal species in small ruminant lentivirus-infected asymptomatic goats

Evaluation of P1' substrate specificity of staphylococcal SplB protease

Anti-staphylococcal potential of Callistemon rigidus

Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity

Proteomics in studies of Staphylococcus aureus virulence

Differences in metabolic profiles of planktonic and biofilm cells in Staphylococcus aureus - 1H Nuclear Magnetic Resonance search for candidate biomarkers

Comparative Anti-Bacterial Effect of Aqueous and Ethanolic Stem Barks of Tamarindus indica Linn on Staphylococcus aureus

Characteristics of advanced methods used for typing bacterial isolates from mastitis with particular reference to Staphylococci

Antimicrobial coatings as a promising prevention strategy of implants infections triggered by Staphylococcus aureus

Antibacterial activity of (PVP-ZrO2) nanocomposite against pathogenic bacteria

Antibiofilm activity against Staphylococcus aureus and content analysis of Taraxacum Officinale phenolic extract

Sepsa jako powikłanie drobnego zranienia