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1

Effect prolonged administration of insecticide-cyhalothrin/karate on the blood and liver of rabbits

100%
Shakoori A. R., Aslam F., Sabir M., Ali S. S.
|
1992
|
vol. 40
|
issue 1-2
91-99
EN
A sublethal dose of Karate administered to rabbits produced a signification increase in the total erythrocyte count and packed cell volume after 15 days of administration, though no significant change was observed after 30 days. The transaminases (glutamate oxaloacetate transaminase, GOT; glutamate pyruvate transaminase, GPT) also increased after 15 days of treatment. The GPT activity increased 119% and 60% after 15 and 30 days, respectively. From amongst metabolites, glucose content increased 17% and 185%, while cholesterol decreased 40% and 66%, and bilirubin 84% and 61%, after 15 and 30 days, respectively. The hepatic AkP activity decreased 30%, while the GPT activity increased 44%. Other enzymes such as AcP, GOT and LDH remained unaffected. The concentration other metabolites, except for FAA which increased 35%, remained unaffected. Histological changes were marked by atrophied hepatic cells and hypertrophied nuclei and nucleoli. A trend towards necrosis of hepatic cells was also observed. All these results indicate that Karate is moderately toxic to mammals.
2

Sublethal effects of Danitol (Fenpropathrin), a synthetic pyrethroid, on Chinesse grass carp, Ctenopharyngodon idella

75%
Ahmad F., Ali S., Shakoori A.
Folia Biologica
|
1995
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vol. 43
|
issue 3-4
151-159
EN
The effects of a sublethal dose of Danitol EC10 administered continously for a total period of 4 weeks, on the blood, liver and muscles of the Chinese grass carp has been described.The haemoglobin content and packed cell volume decreased, whereas the white and red blood cell counts increased after 4 weeks of treatment with the insecticide.The activity of hepatic acid phosphatase, glutamine oxalocetate transaminase (GOT) and lactate dehydrogenase (LDH) was significantly inhibited, while glutamate pyruvate transaminase activity, after an increase during the first two weeks, decreased by the end of the fourth week.The hepatic glycogen and free amino acids (FAA) content increased,while the total protein, glucose andnucleis acids contents decreased.In the muscles the LDH activity was inhibited throughout, while that of creatine phosphokinase showed significant inhibition during the first two weeks only.The soluble and total proteins and RNA content increased during the initial 1-3 weeks of insecticide treatment,while the FAA content remained raised throughout.The muscle glycogen decerased after four weeks of the experimental period.
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