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1

Overlap of sensory representation in rat barrel cortex after neonatal vibrissectomy

100%

Kossut M., Siucinska E.

Acta Neurobiologiae Experimentalis

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1996

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vol. 56

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issue 2

499-505

EN

Cortical repesentation of the common fur of mysticial pad is situated outside poster-medial barrel subfield (PMBSF) in rat primary somatosensory cortex.Following neonatal vibrissectomy, stimulation of the common fur activates the neurone in PMBSF.We examined if sparing of the mystacial vibrissa from the neonatal ablation, which results in a very extensive increase of its cortical repesentation, would prevent the invasion of the common fur inputs into the PMBSF.The cortical representation were mapped with 2-deoxyglucose (2DG).It was found that six weeks after neonatal vibrissectomy sparing C3 vibrissa and common fur inputs were representes into the PMBSF.Their representation shifed from its normal location into the barriel field.This effect was observed in cortical layers II/III, IV and V.

2

Effects of sensory learning on intracortical synaptic transmission in the barrel cortex of mice

88%

Urban-Ciecko J., Kossut M., Hess G.

Acta Neurobiologiae Experimentalis

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2005

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vol. 65

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issue 2

195-200

EN

Pairing tactile stimulation of a row of whiskers with a tail shock results in an expansion of the functional representation of the stimulated whiskers within the primary somatosensory cortex of mice. Using the same paradigm, the present study examined field potentials evoked in ex vivo slices of the barrel cortex. The amplitude of responses, evoked by single and repetitive stimuli in layer IV?layer II/III pathway contained within the barrel column corresponding to the whisker stimulated during training, was unchanged. In contrast, in a transcolumnar pathway from the 'trained' barrel to layer II/III of the neighboring, 'untrained' column, the amplitude of responses was reduced and responses to trains of stimuli applied at 40 Hz, but not at lower frequencies, depressed faster. These data are suggestive of a selective weakening of excitatory transmission and/or enhancement of inhibitory transmission in transcolumnar pathways, which accompany associative learning-induced cortical plasticity.

3

Contextual impact on sensory processing at the barrel cortex of awake rat

75%

Kublik E.

Acta Neurobiologiae Experimentalis

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2004

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vol. 64

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issue 2

229-238

EN

In order to understand the processing of sensory information in different behavioral situations we recorded evoked potentials (EP) to stimulation of a single vibrissa in the barrel cortex of non-anesthetized rat. We attributed the two principal components of the first negative wave (N1) of the cortical EP to the activation of two pyramidal cell populations (supra- and infragranular) of the central barrel-column. A positive wave of longer latency (P2) reflected the activation of the neighboring columns of the barrel cortex. The EPs recorded continuously throughout the experiment could be sorted into two classes dominated by the activity of either infra- or supragranular pyramidal cells. The introduction of an aversive contextual stimuli increased the amplitude of the second component of the N1 wave, which is built up by activation of infragranular cells, and the amplitude of the P2 wave representing excitation of neighboring columns. We hypothesize that increased activity of infragranular cells activates a cortico-thalamo-cortical loop going through the POm nucleus, which finally excites wider areas of primary somatosensory cortex. This spread of activity enables the comparison of information from neighboring vibrissae at the mystacial pad. The general cortical activation caused by the introduction of the contextual stimuli might be induced by noradrenergic and/or cholinergic systems. Prolonged contextual stimulation causes habituation processes, which return the cortical network to an idle state.

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Overlap of sensory representation in rat barrel cortex after neonatal vibrissectomy

Effects of sensory learning on intracortical synaptic transmission in the barrel cortex of mice

Contextual impact on sensory processing at the barrel cortex of awake rat