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Effect of outer membrane proteins from Shigella humoral immunity induced in mice by SRBC

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Czarny A., Witkowska D., Mulczyk M.

Archivum Immunologiae et Therapiae Experimentalis

1992

vol. 40

issue 2

129-134

Shigella flexneri outer membrane proteins (OMP) which had been earlier found to exert immunomodulatory effect on cell mediated immune response were also found to act as immunomodulator of the humoral immune response. Effects of OMP were investigated in the experiments in vitro and in vivo, where the level of humoral immune response measured as the number of plaque-forming cells (PFC) to SRBC in the spleen was evaluated. We demnostrate that small doses of OMP stimulate, whereas higher doses suppress the humoral immunity.

Fraction of spleen cells responsible for suppresion of cellular immune response to SRBC in mice treated with outer membrane proteins of Shigella

100%

Czarny A., Witkowska D., Mulczyk M.

Archivum Immunologiae et Therapiae Experimentalis

1992

vol. 40

issue 2

135-137

Effect of splenocytes isolated from mice immunized with suppressive dose of OMP rfom Shigella on delaed hipersensivity, induced in mice with sheep red blood cells was investigated. Only the population of T lymphocytes was found to suppress the delayed hypersensitivity, as measured by the footpad reaction. The results suggest that OMP of Shigella are able to induce in the spleen of animals active T cells which are responsible for the suppression of cellular response induced by SRBC.

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2 Archivum Immunologiae et Therapiae Experimentalis

2 1992

2 Czarny A.

2 Mulczyk M.

2 Witkowska D.

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Effect of outer membrane proteins from Shigella humoral immunity induced in mice by SRBC

Fraction of spleen cells responsible for suppresion of cellular immune response to SRBC in mice treated with outer membrane proteins of Shigella