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Influence of vegetable oil on the synthesis of bioactive nanocarriers with broad spectrum photoprotection

100%

Niculae G., Lacatusu I., Badea N., Meghea A., Stan R.

Open Chemistry

2014

vol. 12

issue 8

837-850

Due to their unique features, most nanostructured lipid carriers (NLCs) in association with vegetable oils that exhibit UV filtering properties and bioactivity could be used in many cosmetic formulations. Therefore, in this work, a new application of pomegranate seed oil (PSO) in the cosmetic sector was developed, based on the synthesis of bioactive lipid nanocarriers loaded with various UV filters by the hot high pressure homogenization technique. To get broad spectrum photoprotection, different UVA and UVB filters have been used (Avobenzone - AVO, Octocrylen-OCT, Bemotrizinol - BEMT). The influence of the solid lipids combined with PSO on the particle size, physical stability and entrapment efficiency was investigated using 8 nanocarrier systems. An improved physical stability and an appropriate size were obtained for NLCs prepared with Emulgade, carnauba wax and PSO (e.g. −30.9÷-36.9 mV and 160÷185 nm). NLCs showed an entrapment efficiency above 90% and assured slow release rates of UV filters, especially for BEMT (5%). The developed nanocarriers have been formulated into safe and effective sunscreens containing low amounts of synthetic UV filters coupled with a high percent of natural ingredients. The highest SPF of 34.3 was obtained for a cream comprising of 11% PSO and 3.7% BEMT

FORMULATION AND IN VITRO EVALUATION OF FLOATING TABLETS OF PSYLLIUM HUSK & TRAGACANTH USING SITAGLIPTIN PHOSPHATE AS A MODEL DRUG

86%

Ghumman S. A., Andleeb S., Bashir S., Muhammad S. R., Badshah M., Khattak M.

Acta Poloniae Pharmaceutica - Drug Research

2018

vol. 75

issue 3

Abstract A novel floating controlled release drug delivery system of Sitagliptin phosphate was formulated in an effort to increase the gastric retention time of the dosage form and thereby increased drug bioavailability. The tablets were prepared by wet granulation method using Psyllium Husk and tragacanth gum as a release retarding polymers and sodium bicarbonate as a gas generating agent. All the designed nine batches of floating tablets were evaluated for physical characteristics viz. weight variation, thickness, content uniformity, hardness, floating capacity, swelling studies. All formulations had floating lag time of less than 1 min and constantly floated for 12 h except F1, F4 and F7 (that dissolved completely in 8 h or less than 8 h). In vitro drug release studies were carried out for 8 h and release mechanism was further evaluated by linear regression analysis, F9 composed of 30% Psyllium Husk, 10% tragacanth gum and 18% sodium bicarbonate sustained the drug release for longer period. The formulations followed first order kinetics, Higuchi drug release kinetics with diffusion as the dominant mechanism of drug release and the release exponent ranged (0.452-0.635) indicating that the drug release from all formulations was by non-Fickian diffusion mechanism. The prepared floating tablets of STP (F9) might be a promising drug delivery system with sustained release action and improved bioavailability.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 Open Chemistry

1 2018

1 2014

1 Andleeb S.

1 Badea N.

1 Badshah M.

1 Bashir S.

1 Ghumman S. A.

1 Khattak M.

1 Lacatusu I.

1 Meghea A.

1 Muhammad S. R.

1 Niculae G.

1 Stan R.

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Influence of vegetable oil on the synthesis of bioactive nanocarriers with broad spectrum photoprotection

FORMULATION AND IN VITRO EVALUATION OF FLOATING TABLETS OF PSYLLIUM HUSK & TRAGACANTH USING SITAGLIPTIN PHOSPHATE AS A MODEL DRUG