Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl
Preferences help
Polish version English version Language
enabled [disable] Abstract
Number of results

Results found: 4

Number of results on page
first rewind previous Page / 1 next fast forward last

Search results

Search:
in the keywords:  REVERSE TRANSCRIPTASE
help Sort By:

help Limit search:
first rewind previous Page / 1 next fast forward last
1

Reverse transcriptase as the enzyme responsible for the genetic variability of human immunodeficiency virus (HIV)

100%
Kurzynska-Kokorniak A., Jaskolski M., Figlerowicz M.
Biotechnologia
|
2002
|
issue 1
24-34
EN
Human immunodeficiency virus (HIV), the causative agent of AIDS, belongs to the particularly dangerous and, as a result, the most extensively studied viruses. Until now no effective method protecting against this pathogen has been developed. The major problem is the unusual genetic diversity of HIV, which helps the virus to escape from immunological response and to produce drug-resistant mutants. Most of the collected data suggest that HIV-encoded reverse transcriptase (HIV RT) is the main factor responsible for the continuos generation of new viral variants. There are two primary mechanisms involved in the generation of HIV mutants: high error prone replication and genetic RNA recombination. In this article both processes are discussed in detail.
2

Central dogma of molecular biology

80%
Barciszewska M.
Biotechnologia
|
1993
|
issue 3
128-133
EN
In this article evolution of the RNA DNA protein was discussed. Especially some properties of reverse transcriptase were described. Also new findings on RNA catalysis, which make flow chart of the genetic information more complicated were presented.
3

Anti-HIV activities and mechanisms of antisense oligonucleotides

80%
Hatta T., Inagawa T., Kuwasaki T., Kinzuka Y., Takai K., Yokoyama S., Nakashima H., Yamamoto N., Takaku H.
Biotechnologia
|
1996
|
issue 4
116-131
EN
We demonstrated that unmodified and modified (phosphorothioate) oligonucleotides prevent cDNA synthesis by the AMV, MMLV, and HIV reverse transcriptases.WE also describe tha long-term treatment of human immunodeficiency virus-infected cells with antisense phosphorothioate oligonucleotides.
4

Possible ancient origin of heterochromatic JNK sequences in chromosomes 2R of Secale vavilovii Grossh

70%
Achrem M., Rogalska S. M., Kalinka A.
Journal of Applied Genetics
|
2010
|
vol. 51
|
issue 1
1-8
EN
Employing FISH analysis as well as BLAST and CUSTAL W (1.82) programs, we investigated types of DNA nucleotide sequences building an additional heterochromatic band in 2R chromosomes of 3 lines of Secale vavilovii Grossh. The probes used in FISH analysis were designed based on the reverse transcriptase sequence of Ty1-copia and Ty3-gypsy retrotransposons and the 5S rRNA gene sequence. No hybridization signals from the reverse transcriptase probes were observed in the chromosome region where the additional band occurs. On the other hand, signals were observed after hybridization with the 5S rDNA probe, clearly suggesting the presence of that type of sequences in the analyzed heterochromatin band. Using BLAST and CUSTAL W programs, we revealed high similarity of the JNK1 sequence to the 5S rRNA gene from Hordeum chilense (HCH1016, HCH1018, 88%) and to a fragment of the 5S rRNA sequence of H. marinum (HMAR003, 97%). In addition, the same fragment of JNK1 was shown to be very similar to the part of the Angela retrotransposon (92%) as well as to the SNAC 426K20-1 transposon (89%) belonging to CACTA family, both from Triticum monococcum, and to Zingeria biebersteiniana pericentromeric sequences (78%). The similarity of JNK1 to those sequences may be accidental or the JNK1 may represent an ancient mobile genetic element that caught the 5S rRNA sequence. During the evolution those sequences might have been accumulated in the particular region on the 2R chromosome. Our results suggest that the additional heterochromatin band in chromosomes 2R of S. vavilovii is a collection of defective genes and/or mobile genetic elements.
first rewind previous Page / 1 next fast forward last
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.