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1

Inductors and age effects on microsomal electron transfer chain from rat liver

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Plewka A., Kaminski M., Plewka D.
Postępy Higieny i Medycyny Doświadczalnej
|
1994
|
vol. 48
|
issue 5
631-644
EN
In this paper we showed age effect on NADPH-cytochrome P-450 reductase activity, cytochrome b5 and NADH-cytochrome b reductase from rat liver.We discussed effect of some I, II, and III classes inductor also.Activity NADPH-cytochrom P-450 reductase softly decreased from 0.5-2-month of life, but in older groups gradually increased.In 28-month-old rats it was twice fold youngest.Phenobarbital and dexamethasone (without 28-month-old age rats) induced but ?-naphthoflavone inhibited activity of this reductase.Cytochrome b content softly decreased to 4-month of life.In older animals changed of this hemoprotein content were not observed.The examined inductors of monooxygenase system decreased cytochrome b level.NADH-cytochrome b5 reductase activity increased to 1-month of life, but in older group decreased.After 2-month changes of activity were very small only.Phenobarbital, ?-naphthoflavone and dexamothasone inhibited activity of this reductase.
2

Inductors and age modifications of rat liver cytochrome P-450

100%
Plewka A., Plewka D., Kaminski M.
Postępy Higieny i Medycyny Doświadczalnej
|
1994
|
vol. 48
|
issue 4
453-468
EN
In this paper we showed age effect on hepatic level of cytochrome P-450.We discussed effects of inductors on this hemoproteine also.Cytochrome P-450 content increased to 1-month of life, but decreased to 4-month.In the oldest rats cytochrome P-450 increased again.Content of this hemoprotein was induced by phenobarbital and ?- naphthoflavone in all examined groups, especially strong in young animals.Induction effect of dexamethasone was observed in 4-20 month of life.d
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