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1

Novel therapies of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter spp. infections: the state of the art

100%
Wroblewska M.
Archivum Immunologiae et Therapiae Experimentalis
|
2006
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vol. 54
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issue 2
113-120
EN
Gram-negative non-fermenting bacilli, particularly Pseudomonas aeruginosa and Acinetobacter spp., are important opportunistic pathogens in hospitalized patients, contributing to their morbidity and mortality. Recently, a rapid increase in frequency of multidrug-resistant clinical strains is being recorded, making the available therapeutic options very limited. Apart from the development of novel classes of antimicrobials, there is renewed interest in the use of old agents or new combinations of available drugs. Numerous in vitro investigations have been reported on the efficacy of different antimicrobials; however, they should be evaluated in experimental infection models and clinical trials. Novel approaches are being investigated, such as inhibition of virulence factor expression by pathogens or inhibition of their metabolic pathways. The use of bacteriophages, particularly those genetically modified, remains an alternative option in the therapy of infections caused by multidrug-resistant strains. Several vaccines against P. aeruginosa are under development. Apart from therapy with antimicrobial agents, eradication of outbreaks comprises implementation of strict infection control measures and prudent use of antimicrobials.
2

Biodegradation of the oily fraction of petrochemical wastewaters isolated from oily soil

88%
Bieszkiewicz e., Mycielski R., Boszczyk-Maleszak H., Wyszkowska B.
Biotechnologia
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1997
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issue 1
70-78
EN
The paper deals with the possibility of the degradation of the oily fraction of petrochemical wastewaters by bacteria isolated from oily soil.
3

Characteristics of the ability to uptake cadmium by bacteria biosorbents

75%
Wojnowska-Baryla I., Stolarczyk E., Gredzinska A.
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|
issue 4
113-124
EN
The ability of the following bacteria: Escherichia coli, Kliebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Pseudomonas sp. to uptake cadmium from water solution was investigated. Based on the parameters of Freundlich and Langmuir equations it was found that the kind of equation describing cadmium uptake by bacteria cells depended on the range of initial cadmium concentration in solution. Cadmium uptake by the investigated strains of bacteria from solution with low initial concentration of cadmium proceeded according to the Freundlich model. Increasing of the initial cadmium concentration above 30 mg Cd2+? dm-3 resulted in a change of the cadmium uptake mechanism and sorption was according to the Langmuir model. The best biosorbents were Pseudomonas sp. and Proteus vulgaris which showed high sorption ability in a wide range of initial concentrations (1-200 mg Cd2+ ? dm-3). In the range of low initial cadmium concentration (1-30 mg Cd2+? dm-3), the most effective biosorbent was Kliebsiella pneumoniae.
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