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1

Interaction between monocytes and platelets in the vascular wall injure

100%
Giedrojc J.
Postępy Higieny i Medycyny Doświadczalnej
|
1996
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vol. 50
|
issue 3
265-276
EN
Monocytes are highly versatile cells, and their functional capabilities include roles as mediators of inflammation and of the immune response. Moreover, monocytes are involved in vascular lesions, due to their interaction with the endothelium and platelets, and they have been imputed to play a relevant role in the pathogenesis of atherosclerosis. The article describes the potential regulatory role of these cells and interaction with platelets in this process.
2

P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis

51%
Chen M., Geng J.-G.
Archivum Immunologiae et Therapiae Experimentalis
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2006
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vol. 54
|
issue 2
75-84
EN
Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. Cross-linking of PSGL-1 by P-selectin also primes leukocytes intracellularly for cytokine and chemoattractant-induced 2-integrin activation for firm adhesion of leukocytes. Furthermore, P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. Here we provide a comprehensive summary of the functional roles and the biological importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, and the growth and metastasis of cancers.
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