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1

Expression of Npc1 in Glial Cells Corrects Sterility in Npc1-/- mice

100%
Donohue C., Marion S., Erickson R. P.
Journal of Applied Genetics
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2009
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vol. 50
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issue 4
385-390
EN
Niemann-Pick type C1 (NPC) disease is an autosomal recessive neurodegenerative disorder. One feature of the mouse model of NPC1 is it's infertility. We have made transgenic mice which express the Npc1 protein exclusively in fibrillary astrocytes, using the glial fibrillary acidic protein (GFAP) promoter. This selective expression of Npc1 corrects sterility in GFAP-Npc1E, Npc1-/- mice. Counts of acidophils in the pituitary of GFAP-Npc1E, Npc1-/- mice, as compared to Npc1-/- mice, and measurements of dopamine D2 receptor (DRD2) mRNA in the pituitary, suggest mechanisms for fertility enhancement. We conclude that the correction of sterility in GFAP-Npc1E, Npc1-/- mice is a result of restoring hypothalamic control of the pituitary.
2
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Biosythesis of gonadotropins in vivo

88%
Kochman K., Gajewska A.
Acta Neurobiologiae Experimentalis
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1996
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vol. 56
|
issue 3
753-756
EN
GnRh is potent stimulator of gonadotropin's alpha and beta chains synthesis in vivo.Stimulation of LH-beta gene transcription requires pulsatile GnRH administration but the transcription of alpha subunit can be stimulated independently of GnRH mode of administration.Castration increases whereas in vivo estradiol and testostrone replacement decreases the rate of gene transcription of pituitary gonadotropin subunits.Thyroid hormones can enhance or diminsh the pituitery levels of LH-beta and FSH-beta subunit mRNAs in female rats.Inhibin activin and follistatin were shown to be potent regulators of FSH-beta gene expression.
3
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In vitro pituitary prolactin, growth hormone and follicle stimulating hormone secretion during sexual maturation of female rats primed with melatonin

75%
Diaz_ R. E., Fernandez_ A. C., Castrillon P. O., Esquifino_ P. A. I., Diaz_ L. B.
Acta Neurobiologiae Experimentalis
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2001
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vol. 61
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issue 1
27-33
EN
The influence of in vivo melatonin administration on in vitro pituitary follicle stimulating hormone (FSH), growth hormone (GH) and prolactin secretion, as well as the possible influence of dopamine (DA) were evaluated in prepubertal (31-day-old), pubertal (33-day-old) and adult female rats at diestrus phase of the sexual cycle. The in vitro pituitary hormone secretions were evaluated at basal rate for the first hour of incubation only, in Krebs Ringer phosphate (KRP) (I1) and after a second hour of incubation with KRP (I2) or with KRP+DA (I2 plus DA). I1PRL secretion was significantly higher in 33-day-old control and melatonin treated (MEL) rats as compared to I2 periods. However, in 31-day-old rats I1 secretion was higher than in the I2 or I2+DA periods, in MEL rats. In vitro GH secretion was significantly higher at I1 than during I2 periods in the control 31- and 33-day-old groups, but not in MEL rats. The only significant effect of DA was the elevation of GH in prepubertal MEL rats. In vitro FSH release was increased by melatonin in 31-and 33-day-old female rats. No differences in PRL, GH and FSH secretion were found in adult rats. In conclusion, the results show that melatonin effects upon in vitro pituitary gland activity are reproductive-stage-dependent modifying the secretory capacity of the lactotrop, gonadotrop and somatotrop during prepubertal and pubertal ages but not in adult rats studied at a quiescent phase of the sexual cycle.
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