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1

Aerobic actinomycetes and their significance in human and animal pathogenicity. I. Actinomycetal diseases - characteristic, etiology, epidemiology and pathogenesis

100%

Mordarska H.

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issue 3

257-274

EN

Aerobic actionomycetes causing nocardiosis, GRT-(Gordon, Rhodococcus, Tsukamurella) infections, actinomycetomas, dermatophilosis and extrinsic allergic alveolitis, including etiology, epidemiology and pathogenesis of the diseases are described. The name "actinomycetosis" for all these diseases has been proposed. Many clinical important and potential , as well as an increasing number of opportunistic, immunosupressed and immunocompromised cases are discussed. A review of the abundant literature up to date, concerning the problem, is presented.

2

In vitro antagonism of Acremonium mucronatum against Diplodia mutila

100%

Moricca S., Vagniluca S., Dellavalle-Fedi A., Ragazzi A.

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3

Sense and nonsense from whole genome microarray data in the analysis of microbial physiology

100%

Overton T. W., Whitehead R., Li Y., Griffiths L., Cole J.

Biotechnologia

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2008

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issue 1

15-30

EN

The arrival of the post-genomic era has allowed the regulation of every gene or protein of an organism to be studied at once using microarrays for transcriptomic studies, proteomics to analyse gene products, and metabolomics to study the complete complement of products and intermediary metabolites produced by a single person or a single organism. Too often the results of such enterprises are disappointing either because many of the products cannot be identified, or because they are products of genes of unknown function. Success is far more likely to be achieved if the organism to be exploited is thoroughly understood at the levels of genome organisation, regulation, physiology and biochemistry. Typical questions asked in biotechnology and the biopharmaceutical industries include what genes are expressed ? or not expressed ? when recombinant protein production is induced: can they be manipulated to provide a more productive host; and how do successful pathogens survive in the human body when exposed to oxygen starvation or chemical attack by host defence mechanisms. Examples are given of how whole genome microarray data can reveal mechanisms used by bacteria to survive when they are starved of oxygen; what genes are turned on in response to host defence mechanisms such as nitrosative attack; and how pathogens repair damage inflicted by the host defence mechanisms. Striking similarities and fascinating differences are revealed between two major groups of pathogenic bacteria: enteric bacteria that are able to adapt to life both inside and outside an animal host, and the obligate human pathogen, Neisseria gonorrhoeae. Proteins are identified that provide possible targets for biopharmaceutical intervention, and hence illustrate the potential value of whole-genome transcriptomic approaches to biotechnology.

4

Pathogenicity of Fusarium solani (Mart.) Sacc. isolates derived from different plants towards the yellow lupine (Lupinus luteus L.) and the French bean (Phaseolus vulgaris L.)

88%

Panka M., Sadowski C.

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1999

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vol. 40

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issue 4

271-282

EN

The research was conducted to define Fusarium solani specialisation in infecting the yellow lupine and French bean as well as to select nonpathogenic isolates of the fungus to be used in biological control of pathogenic forms of the genus Fusarium. The experiment was conducted in test tubes and pots under laboratory conditions, at 10oC and 20oC with 29 F. solani isolates derived from different plants and from the soil. The pathogenicity of the studied isolates differed considerably. The isolates which were not excised from the yellow lupine and French bean also showed high pathogenicity, which points to lack of F. solani specialisation in those plants. Four of the investigated isolates proved to be slightly pathogenic. None of the obtained isolates was nonpathogenic.

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2 Biotechnologia

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1 Postępy Higieny i Medycyny Doświadczalnej

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1 Cole J.

1 Dellavalle-Fedi A.

1 Griffiths L.

1 Li Y.

1 Mordarska H.

1 Moricca S.

1 Overton T. W.

1 Panka M.

1 Ragazzi A.

1 Sadowski C.

1 Vagniluca S.

1 Whitehead R.

Aerobic actinomycetes and their significance in human and animal pathogenicity. I. Actinomycetal diseases - characteristic, etiology, epidemiology and pathogenesis

In vitro antagonism of Acremonium mucronatum against Diplodia mutila

Sense and nonsense from whole genome microarray data in the analysis of microbial physiology

Pathogenicity of Fusarium solani (Mart.) Sacc. isolates derived from different plants towards the yellow lupine (Lupinus luteus L.) and the French bean (Phaseolus vulgaris L.)