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  1. 1 Journal of Applied Genetics

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  1. 1 2002

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  1. 1 Cebrat S.

  2. 1 Stauffer D.

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Monte Carlo simulation of genome viability with paralog replacement

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Cebrat S., Stauffer D.
Journal of Applied Genetics
|
2002
|
vol. 43
|
issue 3
391-395
EN
Recent analyses of genome content have revealed that many single functions, even in haploid organisms, can be executed by more than one gene. As a result, experimental disruption of many individual genes does not exert lethal effects on the organism or even any visible change in the phenotype of the organism with a knockedout gene. Our analysis shows that such genetic redundancy allows for an appreciably higher mutation load in the genome simulations before the viability of the whole organism is destroyed.
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