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Hyposensitivity to amphetamine following exposure to chlorphenvinphos - protection by amphetamine preexposure

100%

Gralewicz S., Lutz P., Szymczak W.

Acta Neurobiologiae Experimentalis

2000

vol. 60

issue 2

203-207

We investigated the effect of an acute exposure to chlorphenvinphos (CVP), an organophosphate anticholinesterase, on amphetamine-induced open-field locomotion in rats. CVP was administered in a single i.p. dose of 1.0 mg/kg (1/10 of the LD50). All animals were challenged with 1.0 mg/kg amphetamine (AMPH) three weeks after the CVP exposure, i.e. after a time sufficient for acetylcholinesterase recovery. Some rats were also given AMPH three weeks before the CVP exposure. In rats challenged with AMPH only once after the CVP exposure, AMPH- induced open-field locomotion was significantly reduced. Such an effect was not observed in rats given AMPH three weeks before the CVP exposure. The results suggest that a single CVP exposure may result in persistent dopaminergic hyposensitivity, and that an amphetamine pretreatment may protect the rat against this effect.

A morphologixal study of the testes in relation to acetylcholinesterase actvity in the brain and testis of an organophosphate pesticide ingested by a wild passerine bird (Lonchura malabarica)

88%

Maitra S., Sarkar R.

Folia Biologica

1995

vol. 43

issue 3-4

143-149

Oral administration of an organophosphate pesticide, phosphamidon, at sublethal doses caused a decrease in both and testicular acetylcholinesterase (AChE), paired testicular weight, seminiferous tubular diameter, and the number of tubules containing healthy germ cells in the testes of adult whitetroated munias in a dose and duration depended manner.While no significant changes in the cytomorphology and nuclear diameter of Leyding cells were noted in the testes of the experimental birds, a significant negative correlation was observed between the number of semiferous tubules containing degenerated germ cells and the rate of AChE activity in both the testes and in the brain of respective bird groups.These findings demonstrate for the first time that the antigametogenic effects of an OP pesticide on avian tests may be due to impaired cholinergic functions in the brain and/or the testes in the birds concerned.

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1 Acta Neurobiologiae Experimentalis

1 Folia Biologica

1 2000

1 1995

1 Gralewicz S.

1 Lutz P.

1 Maitra S.

1 Sarkar R.

1 Szymczak W.

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Hyposensitivity to amphetamine following exposure to chlorphenvinphos - protection by amphetamine preexposure

A morphologixal study of the testes in relation to acetylcholinesterase actvity in the brain and testis of an organophosphate pesticide ingested by a wild passerine bird (Lonchura malabarica)