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Potential role of bioactive compounds in the prevention of coronavirus: an overview

100%
Senthilkumar V., Ilavenil K. K.
World News of Natural Sciences
|
2023
|
vol. 50
42-51
EN
This study highlights the importance of natural products in drug development, particularly Indian medicinal herbs with high biological potential. Major immunity-developing plant species were collected from the literature. These substances must be synthesized in the lab to enhance the human immune system to fight new viruses like novel corona to promote sustainable processes with little damage. Nature has bestowed numerous plant species with bioactive chemicals that can be utilized safely and effectively to treat various ailments in all living organisms. India, due to its diverse climate, is home to many plant species that possess medicinal properties. Some of the bioactive compounds found in Indian traditional medicine include tannins, phenols, terpenoids, flavonoids, esters, and other small chemicals. These compounds are known to exhibit biological activity and have been utilized in traditional medicinal practices in India.
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Generation of Molecular Shape Diverstiy. From Privileged Scaffolds to Diverted Total Synthesis

84%
Dai W.-M.
Diversity Oriented Synthesis
|
2012
|
vol. 1
|
issue 1
EN
Molecular shape is a presentation of a molecule’s three-dimensional structure and its volume of space and surface electrostatic potential map collectively define the function, e. g. as a modulator or probe to biological targets. Molecular shape diversity for compound libraries with multiple scaffolds (rich skeletal diversity) is recognized as a prerequisite for discovering broad bioactivity. Established strategies and methodologies for diversity-oriented synthesis (DOS) are useful for generating molecular shape diversity by synthesizing natural product-like compounds. On the other hand, diverted total synthesis (DTS) offers natural products and analogues with a higher degree of structural diversity and complexity. Examples of DOS of privileged heterocycles and DTS of amphidinolide T marine macrolides from the author’s laboratories are illustrated.
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