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Chemerin and the recruitment of NK cells to diseased skin*

100%

Skrzeczyńska-Moncznik J., Stefańska A., Zabel B. A., Kapińska-Mrowiecka M., Butcher E. C., Cichy J.

Acta Biochimica Polonica

2009

vol. 56

issue 2

355-360

Natural killer (NK) cells play a major role in the initial control of many viral pathogens and in the rejection of tumors. Consistent with their roles as immune sentinels, NK cells are found in inflamed skin, including lichen planus, psoriasis and atopic dermatitis (AD) lesions. In oral lichen planus lesions, the recruitment as well as intradermal colocalization of NK cells and pDC (plasmacytoid dendritic cells) appear to be mediated by chemerin, a recently identified protein ligand for chemokine-like receptor 1 (CMKLR1), a chemoattractant receptor expressed by both cell types. Dendritic cells can regulate NK cell activity, and NK cells can regulate DC-mediated responses. Since chemerin was recently implicated in recruitment of pDC to psoriatic skin, in this work we determined whether chemerin facilitates interactions between NK and pDC in psoriatic plaques through controlling influx of NK cells to diseased skin. We demonstrate that circulating NK cells from normal donors as well as psoriasis and AD patients respond similarly in functional migration assays to chemerin. However, differences in the distribution of NK cells and pDC in skin lesions suggest that recruitment of both NK cells and pDC is unlikely to be controlled solely by chemerin.

NK cell-based immunotherapies against tumors

88%

Radons J., Stangl S., Multhoff G.

Open Medicine

2006

vol. 1

issue 3

179-204

Natural killer (NK) cells provide the first line of defence against pathogens and tumors. Their activation status is regulated by pro-inflammatory cytokines and by ligands that either target inhibitory or activating cell surface receptors belonging to the immunoglobulin-like, C-type lectin or natural cytotoxicity receptor families. Apart from non-classical HLA-E, membrane-bound heat shock protein 70 (Hsp70) has been identified as a tumor-specific recognition structure for NK cells expressing high amounts of the C-type lectin receptor CD94, acting as one component of an activating heterodimeric receptor complex. Full-length Hsp70 protein (Hsp70) or the 14-mer Hsp70 peptide T-K-D-N-N-L-L-G-R-F-E-L-S-G (TKD) in combination with pro-inflammatory cytokines enhances the cytolytic activity of NK cells towards Hsp70 membrane-positive tumors. Based on these findings cytokine/TKD-activated NK cells were adoptively transferred in tumor patients. These findings were compared to results of clinical trials using cytokine-activated NK cells.

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1 Acta Biochimica Polonica

1 Open Medicine

1 2009

1 2006

1 Butcher E. C.

1 Cichy J.

1 Kapińska-Mrowiecka M.

1 Multhoff G.

1 Radons J.

1 Skrzeczyńska-Moncznik J.

1 Stangl S.

1 Stefańska A.

1 Zabel B. A.

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Chemerin and the recruitment of NK cells to diseased skin*

NK cell-based immunotherapies against tumors