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1

The effect of chronic nifedipine and ECS in the forced swimming test in rats

100%
Czyrak A.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 2
191-195
EN
Chronic, but not acute, electroconvulsive treatment reduced the immobility time of rats in the forced swimming test; nifedipine facilitated that effect.
2

Electroconvulsive shock-induced impairment of spatial learning is aggravated by nifedipine

80%
Popik P., Mamczarz J., Vetulani J.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 2
185-190
EN
Chronic electroconvulsive treatment applied immediately after a training session or with a 15 min delay impairs spatial learning and memory in the Morris water maze paradigm, and this impairment is not counteracted, but rather aggravated by co-administration of a calcium channel blocker, nifedipine.
3

The effect of calcium channel blockade during electroconvulsive treatment on cerebral cortical adrenoceptor subpopulations in the rat

80%
Antkiewicz-Michaluk L., Michalik J., Romanska I., Vetulani J.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 2
197-200
EN
Chronic administration of nifedipine (5 mg/kg/day for 10 days) induced some biochemical effects consistent with those of antidepressants: a significant depression in cortical alfa2-adrenoceptor density and reduction of beta-adrenoceptor affinity; nifedipine co-administration with electroconvulsive treatment potentiated the beta-downregulatory effect of the latter.
4

The effect of chronic treatment with imipramine on the G-proteins mRNA level in the rat hippocampus - an interaction with a calcium channel antagonist

80%
Lason W., Przewlocki R.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 2
219-226
EN
The effect of long-term administration of imipramine (10 mg/kg po, twice daily, 30 days) with or without nifedipine (5 mg/kg ip, twice daily, 28 days) on the G protein alfa subunit, Gs-alfa, Go-alfa and Gi-alfa mRNA levels was investigated in the rat hippocampus. An in situ hybridization histochemistry showed that imipramine decreased the Go-alfa mRNA level in CA1 (by ca. 40%) and CA3 (by ca. 37%) hippocampal fields and, to a lesser extent, in the dentate gyrus (by ca. 25%), but had no effect on the Gs-alfa and Gi-alfa mRNA levels in those structures. Nifedipine decreased (by ca. 30%) the Gs-alfa level in the studied fields of hippocampal formation, having no imfluence on the level of mRNA which codes other subunits of G protein, Coadministration of nifedipine and imipramine reversed the imipramine effect on Go-alfa, but had no effect on the nifedipine induced decrease at the Gs-alfa mRNA level. These results suggest that inhibition of L calcium channels modifies the effect of imipramine at the level of intracellular signal transduction.
5

The effect of chronic treatment with imipramine, ECS and nifedipine on the beta-andrenergic function in the rat hippocampal slices

70%
Frankiewicz T., Legutko B., Czyrak A., Pilc A.
|
EN
Nifedipine administered for either 10 or 28 dayz did not affect the cAMP response to noradrenalina or isoproterenol; however it decreased the inhibitory effect of ECS on the noradrenaline-stimulated cAMP generation.
6

Chronic effects of and on the beta-adrenergic function in neuronal and glial

70%
Legutko B., Frankiewicz T., Czyrak A., Pilc A.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 2
213-218
EN
A 7-day incubation of neuronal and glial cells with (2 myM) did not reduce cAMP response to or , however such an effect was observed when the cells were incubated with imipramine in the calcium channel antagonist nifedipine (1myM).
7

The effect of calcium channel blockade on the action of chronic ECT and imipramine on responses of alpha-1 and beta-adrenoceptors in the rat cerebral cortex

61%
Nalepa I., Vetulani J.
Polish Journal of Pharmacology
|
1993
|
vol. 45
|
issue 2
201-205
EN
Chronic co-administration of nifedipine and ECT or imipramine results in an increase in responsiveness of cerebral cortical alfa1-adrenoceptor as measured by accumulation of inositol phosphate in cortical slices after noradrenaline stimulation; the responsiveness of beta-adrenoceptor, measured by accumulation of cyclic AMP, was depressed similarly by antidepressant treatment with and without nifedipine.
8

The action of antidepressant drugs administered during calcium channel blockade

61%
Vetulani J.
|
EN
This is an overview of the symposium concerned with the action of electroconvulsive treatment and some antidepressant drugs (mainly imipramine) applied during blockade of voltage-dependent calcium channels with nifedipine. The results in general suggest that a combination of calcium channel blockers with antidepressant drugs of ECT may be of clinical value in treatment of depression.
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