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1

Cathepsin D in the diagnosis of neoplastic diseases

100%
Warwas M., Taurowska E.
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vol. 47
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issue 4
277-288
EN
The paper presents a review of results concerning the and its role in tumor invasion and . Special attention was paid to the clinical prognostic value of cathepsin D determination in the breast cancer cytosol.
2

Inhibitors of neoangiogenesis in antitumor therapy

88%
Opolski A., Wietrzyk J.
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vol. 55
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issue 3
369-385
EN
The role of angiogenesis in tumor growth and metastasis is discussed. The endogenous activators and inhibitors of tumor angiogenesis are presented and their mechanisms of action are reviewed. An overview on angiogenesis as a new potential targed of antitumor therapy is described. The clinical trials of various antiangiogenic agents are briefly summarized and their differential mechanisms of action are discussed.
3

Lewis antigens in human colon carcinoma

88%
Dus D., Paprocka M., Matejuk A.
Postępy Higieny i Medycyny Doświadczalnej
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1996
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vol. 50
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issue 5
549-553
EN
Aberrant glycosylation is a common phenomenon accompanying colon carcinoma progression. The changes observed include increased expression of Lewis blood group family antigens, particularly Lex, sialyl Lex and sialyl Lea. Recently it was shown that these antigenic epitopes may play an important role in cell-cell homotypic as well as heterotypic adhesive interactions. This work presents a phenotypic characteristic of 11 human colon carcinoma cell lines of different degree of differentiation expression of potential ligands for endogenous cellular lectins: Lewis antigens, CEA and CD44v6 antigens was evaluated by cytofluorimetry. The aim of the work is to select adhesive and invasive colon carcinoma cells with specified cell surface antigen pattern, for studies on adhesive interactions with endothelial cells, occurring during early steps of metastasis.
4

P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis

51%
Chen M., Geng J.-G.
Archivum Immunologiae et Therapiae Experimentalis
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2006
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vol. 54
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issue 2
75-84
EN
Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. Cross-linking of PSGL-1 by P-selectin also primes leukocytes intracellularly for cytokine and chemoattractant-induced 2-integrin activation for firm adhesion of leukocytes. Furthermore, P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. Here we provide a comprehensive summary of the functional roles and the biological importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, and the growth and metastasis of cancers.
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