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1

Effect of outer membrane proteins from Shigella humoral immunity induced in mice by SRBC

100%
Czarny A., Witkowska D., Mulczyk M.
Archivum Immunologiae et Therapiae Experimentalis
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1992
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vol. 40
|
issue 2
129-134
EN
Shigella flexneri outer membrane proteins (OMP) which had been earlier found to exert immunomodulatory effect on cell mediated immune response were also found to act as immunomodulator of the humoral immune response. Effects of OMP were investigated in the experiments in vitro and in vivo, where the level of humoral immune response measured as the number of plaque-forming cells (PFC) to SRBC in the spleen was evaluated. We demnostrate that small doses of OMP stimulate, whereas higher doses suppress the humoral immunity.
2

Studies of immunity in mice immunized with outer membrane proteins of Hafnia

100%
Witkowska D., Czarny A., Mulczyk M.
Archivum Immunologiae et Therapiae Experimentalis
|
1992
|
vol. 40
|
issue 2
119-124
EN
Nonspecific protection induced in mice after administration outer membrane proteins of Hafnia alvei against infection with homologue and heterologous bacteria was transferred into other mice with lymphocytes isolated from spleens of mice immunized with outer membrane proteins. It was also found that mice sensitized with outer membrane proteins derived from H. alvei or with living bacteria induced in animals delayed hypersensitivity (DTH) in homologous and heterologous systems. The observed type of hypersensitivity was transferable to normal mice by lymphocytes obtained from donor animals which were previously sensitized with OMP. The experiments revealed that immunity induced with outer membrane proteins of Hafnia alvei is cell-mediated.
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