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APPLICABILITY OF THE EVIDEM MULTI-CRITERIA DECISION ANALYSIS FRAMEWORK FOR ORPHAN DRUGS – RESULTS FROM A STUDY IN 7 EURASIAN COUNTRIES.

100%

Baran-Kooiker A., ATIKELER K., GAITOVA K., HOLOWNIA-VOLOSKOVA M., TURCU-STIOLICA A., Kooiker C., PINIAZHKO O., CZECH M.

Acta Poloniae Pharmaceutica - Drug Research

2019

vol. 76

issue 3

581-598

Several Multi-Criteria Decision Analysis (MCDA) models for use in health technology assessment (HTA) have been developed over the years, including some for orphan drugs (OD). However, there is no general consensus yet on MCDA structure and which criteria should be included and implementation of MCDA into HTA practice has been slow so far. Our study tested the criteria preferences and possibilities for implementation of the EVIDEM MCDA framework for OD with a diverse group of 140 stakeholders in Kazakhstan, Netherlands, Poland, Romania, Russia, Turkey and Ukraine (KZ,NL,PL,RO,RU,TR,UA). The research elicited stakeholder preferences (weighting) for EVIDEM domains, criteria and sub-criteria to measure their relative importance. Correlations of work place and HTA/rare diseases experience with weighting results were investigated. Results showed that the ‘Need for intervention’ domain was assessed as the most important in: RO/NL/RU/TR, in KZ/PL the ‘Type of benefit of intervention’ and in UA ‘Economic consequences of intervention’. ‘Population Priorities’ was uniformly given a low priority. Further research, sharing of experiences and multi-stakeholder discussion is necessary to define a path forward for a robust and sustainable improvement of MCDA models and its application in orphan drug HTA. Model simplification and clarification of outcomes would be beneficial.

Mapping of Soil Erosion Hotspot Areas Using GIS Based-MCDA Techniques in South Gondar Zone, Amhara Region, Ethiopia

84%

Teshome A., Halefom A.

World News of Natural Sciences

2019

vol. 24

218-238

In the highlands of the country in which the study area found was affected by soil erosion and desertification. This problem on the environment includes loss of soil fertility, reduction of the depth of water body (lakes, ponds, reservoirs etc), high water turbidity, flood hazard problems etc. This study focus on mapping of soil erosion prone areas in South Gondar zone (area: 14604 sq km), which comprises of Blue Nile river basin and Tekeze river basins. This study leads where the most effective soil conservation strategies should focus in the area. Based on GIS with the integration of the Multi Criteria Decision Analysis (MCDA), an attempt was made to combine a set of factors (Land use, Soil, Slope, Topographic Wetness Index, Stream Power Index, Elevation, and Curvature) to have a fruitful decision to fulfil to the stated objective. Raster based pairwise comparison method considering seven soil erosion motivating parameters have been done in Arc GIS environments. MCDA is used to quantify the raster based qualitative spatial erosion hotspot area which produced through pairwise comparison. Raster based spatial model tells that out of total watershed area, 39.31 sq km (0.27%), 33.40 sq km (0.23%), 2358.12 sq km (16.15%), 11027.76 sq km (75.51%) and 1145.60 sq km (7.84%) areas are very high, High, Medium, Low and Very low prone to soil erosion respectively. This study will serve as insight to Basins/watershed decision maker and planners to alleviate soil erosion problems and its related hazards.

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1 Acta Poloniae Pharmaceutica - Drug Research

1 World News of Natural Sciences

2 2019

1 ATIKELER K.

1 Baran-Kooiker A.

1 CZECH M.

1 GAITOVA K.

1 HOLOWNIA-VOLOSKOVA M.

1 Halefom A.

1 Kooiker C.

1 PINIAZHKO O.

1 TURCU-STIOLICA A.

1 Teshome A.

Search results

APPLICABILITY OF THE EVIDEM MULTI-CRITERIA DECISION ANALYSIS FRAMEWORK FOR ORPHAN DRUGS – RESULTS FROM A STUDY IN 7 EURASIAN COUNTRIES.

Mapping of Soil Erosion Hotspot Areas Using GIS Based-MCDA Techniques in South Gondar Zone, Amhara Region, Ethiopia