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Tumor resistance to CD8+ T cell-based therapeutic vaccination

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Huang Y., Shah S., Qiao L.
Archivum Immunologiae et Therapiae Experimentalis
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2007
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vol. 55
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issue 4
205-217
EN
CD8+ cytotoxic T lymphocytes (CTLs) play an important role in antitumor immunity. Induction of tumor-specific CTLs is one major strategy for tumor immunotherapy. However, therapeutic vaccinations used to treat firmly established tumors are generally ineffective. A thorough understanding of the mechanisms underlying tumor resistance to CTL-based therapeutic vaccination is very important in the tumor immunology field. There are two main mechanisms by which tumors develop resistance to CTL-based therapeutic vaccinations. One is that tumors induce peripheral tolerance of tumor-specific CD8+ T cells. The other is that tumor cells themselves develop immune evasion mechanisms to prevent recognition and killing by CTLs. This review focuses on recently reported cellular and molecular mechanisms of CD8+ T cell tolerance and immune evasion in tumors and discusses about the possibilities to improve tumor immunotherapy.
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