Luliberin ? luteinizing hormone-releasing hormone (LHRH) is the first link in hypothalamus-pituitary-gonads axis which participates in reproduction. This hormone and lutropin are released from immunological cells, however antagonists of LHRH inhibit this action. Some cytokines (IL-1?, GM-CSF) inhibit release of LHRH and other (IL-6, INF-?) stimulate this release.
Luliberyn plays a pivotal role in the reproductive system. Its analogs have wide therapeutic applications ranging form the treatment of some human cancers, gynecological and sexually transmitted diseases to animal breeding. In the article, the development of luliberin agonists and antagonists and the principles of their application were briefly reviewed. Sequences of some important natural and synthetic analogs were presented. Carcinogenic and biodegradation resistable derivatives of luliberin analogs were also described.
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