Search results

Search:
in the keywords: LOW DENSITY LIPOPROTEIN

Sort By:

Limit search:

Structure and function of in familial

100%

Boguslawski W.

vol. 47

issue 1

55-65

and of the in genetic disorder - familial is described as well as the structure of . General outline of therapy in FH is also described.

The role of oxidatively modified low density lipoprotein in the pathogenesis of atherosclerosis

88%

Siennicka A., Zapolska-Downar D.

Postępy Higieny i Medycyny Doświadczalnej

2003

vol. 57

issue 2

219-237

The precise mechanisms of LDL oxidation in vivo are not well-known but the presence of several enzymes and agents capable of modifying LDL particles was noted in arterial wall. These reactive agents modify lipid, protein as well as antioxidant component of the LDL particles. Postsecretory modification in LDL structure trigger its atherogenic potential. LDL particles retained in the artery wall interact with the various forms of proteoglycans in the extracellular matrix, that increases the resident time of LDL in endothelial space and allows extensive modification. The modified forms of LDL are able to activate intimal cells and to trigger various inflammatory signals. In turn, activated intimal cells can secrete enzymes and agents capable of modifying LDL. These processes can initiate and maintain a vicious circle in the intima and lead to lesion progression.

Refine search results

2 Postępy Higieny i Medycyny Doświadczalnej

1 2003

1 1993

1 Boguslawski W.

1 Siennicka A.

1 Zapolska-Downar D.

Search results

Structure and function of in familial

The role of oxidatively modified low density lipoprotein in the pathogenesis of atherosclerosis