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1

Lipid peroxidation in pathogenesis of atherosclerosis

100%
Skoczynska A., Andrzejak R.
Postępy Higieny i Medycyny Doświadczalnej
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1997
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vol. 51
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issue 5
515-529
EN
The participation of lipid peroxidation in pathogenesis of atherosclerosis is described. The role of antioxidants as well as the importance of dysfunction of endothelium cells in the vessel wall injury is shown.
2

Regulation of intracellular processes by fatty acids and end products of lipid peroxidation

80%
Przybyszewski W. M., Walichiewicz P.
Postępy Higieny i Medycyny Doświadczalnej
|
2002
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vol. 56
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issue 6
741-756
EN
Products of ingested fat metabolism and also products of lipid peroxidation influenced on genes expression being natural ligands for nuclear receptors functioning as a transcription factors. This situation creates possibilities of diet modification by type and amount of fat as an important element of cancer prevention and cancer therapy. Functioning and activity of PPARs indicating the way of controlling their activity by another ligands than that included in the diet. This is a base for pharmacologic synthesis of a new class of specific drugs as an agonists for nuclear receptors of precisely defined histologic type of cancer.
3

Free radical concepction of etiopathogenesis of Graves-Basedow disease

80%
Komosinska-Vassev K., Olczyk K., Winsz K.
Postępy Higieny i Medycyny Doświadczalnej
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2000
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vol. 54
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issue 2
225-237
EN
Increased metabolism due to hyperthyroidism leads to the dysfunction of the mitochondria respiratory chain, resulting in elevated formation of the reactive oxygen species in the course of Graves-Basedov disease. It has also been reported that excessive thyroid hormone level may induce oxidative tissue injury. Furthermore, Graves-Basedow disease is frequently associated with changes of the antioxidant defence system activity. The disturbed balance between oxidative and antioxidative processes may be of significant importance in the pathogenesis of Graves-Basedow disease.
4

Ferrous ion induced photon emission as a method to quantify oxidative stress in stored boar spermatozoa

70%
Gogol P., Pieszka M.
Folia Biologica
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2008
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vol. 56
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issue 3-4
173-177
EN
The aim of the study was to evaluate the effect of semen storage on ferrous ion induced luminescence of boar spermatozoa and to determine the relationship between parameters of this luminescence and lipid peroxidation as measured by malondialdehyde (MDA) contents. Boar semen samples were diluted in Biosolwens extender and stored for 12 days at 15oC. Luminescence andMDA were measured directly after dilution (day 0) and at 6 and 12 days of semen storage. Luminescence was measured at 20oC using a luminometer equipped with a cooled photomultiplier with a spectral response range from 370 to 620 nm. Emission was induced by adding FeSO4 solution (final concentration 0.05mM). MDA content was measured by the HPLC method. The day of storage had a significant effect on some luminescence parameters and MDA content in spermatozoa. A significant correlation was observed between luminescence parameters andMDA concentration. The results of the study confirm that induced luminescence is strictly related to lipid peroxidation in spermatozoa that occur during boar semen storage. Parameters of luminescence treated as a holistic response of cells to oxidati semen preservation.
5

Concentration of TBA-reactive substances in type II pneumocytes exposed to oxidative stress

70%
Piotrowski W. J., Marczak J., Kurmanowska Z., Gorski P.
Archivum Immunologiae et Therapiae Experimentalis
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2004
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vol. 52
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issue 6
435-440
EN
Oxidative lung damage may be associated with the destruction of alveolar cells. Type II alveolar epithelial cells (AECs), as progenitors of type I cells, are indispensable for the renovation of alveolar structure after lung injury. Extensive damage to type II cells could be responsible for unfavorable outcome. However, the susceptibility of type II AECs to oxidative stress is unclear. Materials We investigated the susceptibility of freshly isolated and cultured rat type II AECs to and Methods: oxidative stress (H2O2 and Fe2+). Thiobarbituric acid reactive substances (TBARS) were measured as indices of lipid peroxidation and cytotoxicity was estimated by the MTT test. Aminotriazol (ATZ), an inhibitor of intracellular catalase, was used to estimate the protective role of catalase. Results: TBARS concentration increased significantly in freshly isolated, oxidant-exposed cells (4.0?1.3 vs. 8.3?2.2 nmol/g protein, p=0.0313) and insignificantly in cultured cells (1.7?0.4 vs. 4.4?1.7 nmol/g protein). ATZ was toxic even to cells not exposed to oxidants. Inhibition of catalase in cells exposed to oxidants resulted in an insignificant increase in TBARs: 4.5?1.5 vs. 16.2?3.9 nmol/g protein, p=0.0625, and 4.0?0.8 vs.7.6?4.0 for freshly isolated and cultured cells, respectively. Oxidative stress itself did not increase cytotoxicity. Conclusions: Type II AECs are not resistant to oxidative stress. We cannot, however, explain why cells with evidence of lipid peroxidation do not show increased cytotoxicity. The toxicity of ATZ is not related to oxidative cell damage. In cells exposed to oxidants, TBARS may further increase when catalase is inhibited, which suggests an important protective role for catalase.
6

The application of photon emission measurements for evaluation of semen biological value

61%
Godlewski M., Gogol P., Kwiecinska T., Laszczka A., Szczesniak-Fabianczyk B., Wierzuchowska D.
Biotechnologia
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2003
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issue 1
116-228
EN
Improvements in the single photon counting method have made it possible to measure total emission intensity to monitor its kinetics and to make measurements (using cut-off filters) of the spectral distribution of electromagnetic radiation emitted from spermatozoa of three farm animals species. The association between peroxidation processes in cell membranes and the accompanying photon emission and sperm viability, sperm motility and metabolic processes was identified and further explored. The application part of the studies concerned the effect of stress factors on bull, ram and boar spermatozoa and the possibility of using ultraweak luminescence as a new biophysical method for evaluation of semen biological value. The obtained results indicate that measurements of ultraweak luminescence can prove useful for solving problems related to the evaluation, conservation and use of farm animal semen.
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